LOCUS       CAB5247930.1             442 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CONSERVED TRANSMEMBRANE PROTEIN protein.
ACCESSION   LT708304-229
PROTEIN_ID  CAB5247930.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0224"
                     /note="Mb0224, -, len: 442 aa. Equivalent to Rv0218, len:
                     442 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.5% identity in 442 aa overlap). Probable conserved
                     transmembrane protein, some similarity with sulfite
                     oxidases (EC 1.8.3.1) e.g. SUOX_HUMAN|P51687 sulfite
                     oxidase precursor (488 aa), FASTA scores: opt: 153, E():
                     0.0087, (28.6% identity in 161 aa overlap); and with some
                     nitrate reductases (EC 1.6.6.3) e.g. NIA_FUSOX|P39863
                     nitrate reductase (NADPH) (905 aa), FASTA scores: opt:
                     143, E(): 0.06, (29.3% identity in 92 aa overlap). Also
                     similar to BSUB0017_86 from Mycobacterium tuberculosis.
                     Mb0224 found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
BEGIN
        1 MSDPARGAEA EDAYGFPAGL WRWLQRHPPP ALHRLTRFRS PLRGPWLTSV FGLVLLVALP
       61 FVIITGLLSY IAYAPQLGQA IPGDVGWLRL PAFTWPTRPS WLYRLTQGLH VGLGLVIIPV
      121 VLAKLWSVIP RLFVWPPARS IAQVLERLSV LMLVGGILFQ IVTGVLNIQY DYIFGFSFYT
      181 GHYFGAWVFI AGFLLHIVVK IPHMVTGLRS IPMREVLGTN VADTRAQPCD PDGLVSVNPG
      241 EATLSRRGAL GLVGAGVLLI GVLTVGQTLG GFTRKAALLL PRGRVVSPGD FPVNKTAAAA
      301 GITAEAIGPD WRLVLRGGPA EVVLDRATLA GLPQRTARLP LACVEGWSAV RTWSGVPLAE
      361 LALLAGVPAA RSARVTSLQR GGAFGEAKLA ANQIADPDAL LALRVDGADL SLNHGYPARI
      421 IVPALPGVHN TKWVAGIEFH KR
//