LOCUS       CAB5247910.1             663 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            zinc metalloprotease zmp1 protein.
ACCESSION   LT708304-209
PROTEIN_ID  CAB5247910.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="zmp1"
                     /locus_tag="BQ2027_MB0204C"
                     /note="Mb0204c, -, len: 663 aa. Equivalent to Rv0198c,
                     len: 663 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 663 aa overlap). Probable zinc
                     metalloprotease (EC 3.4.24.-), equivalent to
                     Z95398|MLCL622.12c from Mycobacterium leprae (667 aa),
                     FASTA scores: opt: 3710, E(): 0, (80.8 % identity in 667
                     aa overlap). Also similar to many other metalloproteases
                     e.g. members of the eukaryotic neprilysin family:
                     P08473|NEP_HUMAN NEPRILYSIN (EC 3.4.24.11) (749 aa), FASTA
                     scores: opt: 872, E(): 0, (31.1% identity in 692 aa
                     overlap); Q07744|PEPO_LACLA NEUTRAL ENDOPEPTIDASE from
                     Lactococcus lactis (626 aa), FASTA scores: opt: 862, E():
                     0, (30.0% identity in 654 aa overlap). Contains PS00142
                     Neutral zinc metallopeptidases, zinc-binding region
                     signature. BELONGS TO PEPTIDASE FAMILY M13 (ZINC
                     METALLOPROTEASE); ALSO KNOWN AS THE NEPRILYSIN SUBFAMILY.
                     Protein product from Mb0204c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb0204c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
BEGIN
        1 MTLAIPSGID LSHIDADARP QDDLFGHVNG RWLAEHEIPA DRATDGAFRS LFDRAETQVR
       61 DLIIQASQAG AAVGTDAQRI GDLYASFLDE EAVERAGVQP LHDELATIDS AADATELAAA
      121 LGTLQRAGVG GGIGVYVDTD SKDSTRYLVH FTQSGIGLPD ESYYRDEQHA AVLAAYPGHI
      181 ARMFGLVYGG ESRDHAKTAD RIVALETKLA DAHWDVVKRR DADLGYNLRT FAQLQTEGAG
      241 FDWVSWVTAL GSAPDAMTEL VVRQPDYLVT FASLWASVNV EDWKCWARWR LIRARAPWLT
      301 RALVAEDFEF YGRTLTGAQQ LRDRWKRGVS LVENLMGDAV GKLYVQRHFP PDAKSRIDTL
      361 VDNLQEAYRI SISELDWMTP QTRQRALAKL NKFTAKVGYP IKWRDYSKLA IDRDDLYGNV
      421 QRGYAVNHDR ELAKLFGPVD RDEWFMTPQT VNAYYNPGMN EIVFPAAILQ PPFFDPQADE
      481 AANYGGIGAV IGHEIGHGFD DQGAKYDGDG NLVDWWTDDD RTEFAARTKA LIEQYHAYTP
      541 RDLVDHPGPP HVQGAFTIGE NIGDLGGLSI ALLAYQLSLN GNPAPVIDGL TGMQRVFFGW
      601 AQIWRTKSRA AEAIRRLAVD PHSPPEFRCN GVVRNVDAFY QAFDVTEDDA LFLDPQRRVR
      661 IWN
//