LOCUS       CAB5247906.1            1194 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            transmembrane multidrug efflux pump protein.
ACCESSION   LT708304-205
PROTEIN_ID  CAB5247906.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0200"
                     /note="Mb0200, -, len: 1194 aa. Equivalent to Rv0194, len:
                     1194 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.7% identity in 1194 aa overlap). Probable
                     drugs-transport transmembrane protein ATP binding protein
                     ABC transporter (see citation below), highly similar to
                     many e.g. U62129|STU62129_2|T30293 ABC transport protein
                     homolog from Salmonella typhi (1218 aa), FASTA scores:
                     opt: 1116, E(): 0, (36.3% identity in 1209 aa overlap);
                     CAB66302.1|AL136519 ABC transporter protein ATP-binding
                     component from Streptomyces coelicolor (1243 aa); I84547
                     mdl protein from Escherichia coli (1143 aa); etc. Also
                     similar to MTCY50_9 and MTCY50_10 from Mycobacterium
                     tuberculosis, FASTA score: (33.8% identity in 574 aa
                     overlap). Contains two PS00017 ATP/GTP-binding site motif
                     A (P-loop) and one PS00211 ABC transporters family
                     signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN
                     FAMILY (ABC TRANSPORTERS). Alternative start possible at
                     1823 but no RBS. Protein product from Mb0200 detected
                     using shotgun mass spectrometry."
BEGIN
        1 MRTNCWWRLS GYVMRHRRDL LLGFGAALAG TVIAVLVPLV TKRVIDDAVA ADHRPLAPWA
       61 VVLVAAAGAT YLLTYVRRYY GGRIAHLVQH DLRMDAFQAL LRWDGRQQDR WSSGQLIVRT
      121 TNDLQLVQAL LFDVPNVLRH VLTLLLGVAV MTWLSVPLAL LAVLLVPVIG LIAHRSRRLL
      181 AAATHCAQEH KAAVTGVVDA AVCGIRVVKA FGQEERETVK LVMASRALYA AQLRVARLNA
      241 HFGPLLQTLP ALGQMAVFAL GGWMAAQGSI TVGTFVAFWA CLTLLARPAC DLAGMLTIAQ
      301 QARAGAVRVL ELIDSRPTLV DGTKPLSLEA RLSLEFQRVS FGYVADRPVL REISLSVRAG
      361 ETLAVVGAPG SGKSTLASLA TRCYDVTQGA VRIGGQDVRE LTLDSLRSAI GLVPEDAVLF
      421 SGTIGANIAY GRPDATPEQI ATAARAAHIE EFVNTLPDGY QTAVGARGLT LSGGQRQRIA
      481 LARALLHQPR LLIMDDPTSA VDAVIECGIQ EVLREAIADR TAVIFTRRRS MLTLADRVAV
      541 LDSGRLLDVG TPDEVWERCP RYRELLSPAP DLADDLVVAE RSPVCRPVAG LGTKAAQHTN
      601 VHNPGPHDHP PGPDPLRRLL REFRGPLALS LLLVAVQTCA GLLPPLLIRH GIDVGIRRHV
      661 LSALWWAALA GTATVVIRWV VQWGSAMVAG YTGEQVLFRL RSVVFAHAQR LGLDAFEDDG
      721 DAQIVTAVTA DVEAIVAFLR TGLVVAVISV VTLVGILVAL LAIRARLVLL IFTTMPVLAL
      781 ATWQFRRASN WTYRRARHRL GTVTATLREY AAGLRIAQAF RAEYRGLQSY FAHSDDYRRL
      841 GVRGQRLLAL YYPFVALLCS LATTLVLLDG AREVRAGVIS VGALVTYLLY IELLYTPIGE
      901 LAQMFDDYQR AAVAAGRIRS LLSTRTPSSP AARPVGTLRG EVVFDAVHYS YRTREVPALA
      961 GINLRIPAGQ TVVFVGSTGS GKSTLIKLVA RFYDPTHGTV RVDGCDLREF DVDGYRNRLG
     1021 IVTQEQYVFA GTVRDAIAYG RPDATDAQVE RAAREVGAHP MITALDNGYL HQVTAGGRNL
     1081 SAGQLQLLAL ARARLVDPDI LLLDEATVAL DPATEAVVQR ATLTLAARRT TLIVAHGLAI
     1141 AEHADRIVVL EHGTVVEDGA HTELLAAGGH YSRLWAAHTR LCSPEITQLQ CIDA
//