LOCUS       CAB5247903.1             413 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CONSERVED INTEGRAL MEMBRANE PROTEIN protein.
ACCESSION   LT708304-202
PROTEIN_ID  CAB5247903.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0197"
                     /note="Mb0197, -, len: 413 aa. Equivalent to Rv0191, len:
                     413 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 413 aa overlap). Probable conserved
                     integral membrane protein, member of major facilitator
                     superfamily (MFS) possibly involved in transport of drug,
                     similar to several hypothetical proteins e.g.
                     YDEA_ECOLI|P31122 hypothetical 42.5 kd protein from
                     Escherichia coli (396 aa), FASTA scores: opt: 475, E():
                     4.2e-33, (29.7% identity in 381 aa overlap); and to
                     several chloramphenicol resistance proteins e.g.
                     CMLR_STRLI|P31141 chloramphenicol resistance protein from
                     stremtomyces lividans (392 aa), FASTA scores: opt: 394,
                     E(): 6.7e-12, (28.2% identity in 383 aa overlap). Also
                     similar to SVU09991_1 from Mycobacterium tuberculosis.
                     Protein product from Mb0197 detected using SWATH mass
                     spectrometry. Mb0197 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
BEGIN
        1 MTAPTGTSAT TTRPWTPRIA TQLSVLACAA FIYVTAEILP VGALSAIARN LRVSVVLVGT
       61 LLSWYALVAA VTTVPLVRWT AHWPRRRALV VSLVCLTVSQ LVSALAPNFA VLAAGRVLCA
      121 VTHGLLWAVI APIATRLVPP SHAGRATTSI YIGTSLALVV GSPLTAAMSL MWGWRLAAVC
      181 VTGAAAAVAL AARLALPEMV LRADQLEHVG RRARHHRNPR LVKVSVLTMI AVTGHFVSYT
      241 YIVVIIRDVV GVRGPNLAWL LAAYGVAGLV SVPLVARPLD RWPKGAVIVG MTGLTAAFTL
      301 LTALAFGERH TAATALLGTG AIVLWGALAT AVSPMLQSAA MRSGGDDPDG ASGLYVTAFQ
      361 IGIMAGALLG GLLYERSLAM MLTASAGLMG VALFGMTVSQ HLFENPTLSP GDG
//