LOCUS       CAB5247901.1             575 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            DIHYDROXY-ACID DEHYDRATASE ILVD (DAD) protein.
ACCESSION   LT708304-200
PROTEIN_ID  CAB5247901.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="ilvD"
                     /locus_tag="BQ2027_MB0195C"
                     /note="Mb0195c, ilvD, len: 575 aa. Equivalent to Rv0189c,
                     len: 575 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 575 aa overlap). Probable ilvD,
                     dihydroxy-acid dehydratase (EC 4.2.1.9), similar to many
                     e.g. ILVD_LACLA|Q02139 dihydroxy-acid dehydratase (dad)
                     from Lactococcus lactis (subsp. lactis) (Streptococcus
                     lactis) (570 aa), FASTA scores: opt: 1605, E(): 0, (46.0%
                     identity in 561 aa overlap). Also similar to
                     ML2608|MLCL622.06c|O06069|ILVD_MYCLE DIHYDROXY-ACID
                     DEHYDRATASE from Mycobacterium leprae (564 aa). Contains
                     PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases
                     signature 1. BELONGS TO THE ILVD / EDD FAMILY. COFACTOR:
                     BINDS 1 4FE-4S CLUSTER (POTENTIAL). Protein product from
                     Mb0195c detected using shotgun mass spectrometry and SWATH
                     mass spectrometry. Mb0195c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
BEGIN
        1 MPQTTDEAAS VSTVADIKPR SRDVTDGLEK AAARGMLRAV GMDDEDFAKP QIGVASSWNE
       61 ITPCNLSLDR LANAVKEGVF SAGGYPLEFG TISVSDGISM GHEGMHFSLV SREVIADSVE
      121 VVMQAERLDG SVLLAGCDKS LPGMLMAAAR LDLAAVFLYA GSILPGRAKL SDGSERDVTI
      181 IDAFEAVGAC SRGLMSRADV DAIERAICPG EGACGGMYTA NTMASAAEAL GMSLPGSAAP
      241 PATDRRRDGF ARRSGQAVVE LLRRGITARD ILTKEAFENA IAVVMAFGGS TNAVLHLLAI
      301 AHEANVALSL QDFSRIGSGV PHLADVKPFG RHVMSDVDHI GGVPVVMKAL LDAGLLHGDC
      361 LTVTGHTMAE NLAAITPPDP DGKVLRALAN PIHPSGGITI LHGSLAPEGA VVKTAGFDSD
      421 VFEGTARVFD GERAALDALE DGTITVGDAV VIRYEGPKGG PGMREMLAIT GAIKGAGLGK
      481 DVLLLTDGRF SGGTTGLCVG HIAPEAVDGG PIALLRNGDR IRLDVAGRVL DVLADPAEFA
      541 SRQQDFSPPP PRYTTGVLSK YVKLVSSAAV GAVCG
//