LOCUS       CAB5247885.1             515 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 MCE-
            FAMILY PROTEIN MCE1F protein.
ACCESSION   LT708304-184
PROTEIN_ID  CAB5247885.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mce1F"
                     /locus_tag="BQ2027_MB0180"
                     /note="Mb0180, mce1F, len: 515 aa. Equivalent to Rv0174,
                     len: 515 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 515 aa overlap). mce1F; belongs to
                     24-membered Mycobacterium tuberculosis Mce protein family
                     (see citations below for more information), similar to
                     Mycobacterium tuberculosis proteins
                     O07784|Rv0594|MTCY19H5.28c|mce2F (516 aa);
                     O53972|Rv1971|MTV051.09|mce3F (437 aa); etc. Also highly
                     similar to others e.g. NP_302661.1|NC_002677 putative
                     secreted protein from Mycobacterium leprae (516 aa);
                     AAF74993.1|AF143400_1|AF143400|996A027a protein from
                     Mycobacterium avium (80 aa) (similarity on C-terminus);
                     CAC12793.1|AL445327 putative secreted protein from
                     Streptomyces coelicolor (433 aa); etc. Has hydrophobic
                     stretch, possibly a signal peptide at the N-terminus.
                     Protein product from Mb0180 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb0180 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MLTRFIRRQL ILFAIVSVVA IVVLGWYYLR IPSLVGIGQY TLKADLPASG GLYPTANVTY
       61 RGITIGKVTA VEPTDQGARV TMSIASNYKI PVDASANVHS VSAVGEQYID LVSTGAPGKY
      121 FSSGQTITKG TVPSEIGPAL DNSNRGLAAL PTEKIGLLLD ETAQAVGGLG PALQRLVDST
      181 QAIVGDFKTN IGDVNDIIEN SGPILDSQVN TGDQIERWAR KLNNLAAQTA TRDQNVRSIL
      241 SQAAPTADEV NAVFSGVRDS LPQTLANLEV VFDMLKRYHA GVEQLLVFLP QGAAIAQTVL
      301 TPTPGAAQLP LAPAINYPPP CLTGFLPASE WRSPADTSPR PLPSGTYCKI PQDAQLQVRG
      361 ARNIPCVDVP GKRAATPKEC RSKDPYVPLG TNPWFGDPNQ ILTCPAPGAR CDQPVKPGLV
      421 IPAPSINTGL NPAPADQVQG TPPPVSDPLQ RPGSGTVQCN GQQPNPCVYT PTSGPSAVYS
      481 PASGELVGPD GVKYAVANSS TTGDDGWKEM LAPAS
//