LOCUS       CAB5247882.1             515 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 MCE-
            FAMILY PROTEIN MCE1C protein.
ACCESSION   LT708304-181
PROTEIN_ID  CAB5247882.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mce1C"
                     /locus_tag="BQ2027_MB0177"
                     /note="Mb0177, mce1C, len: 515 aa. Equivalent to Rv0171,
                     len: 515 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 515 aa overlap). mce1C; belongs to
                     24-membered Mycobacterium tuberculosis Mce protein family
                     (see citations below for more information), highly similar
                     to Mycobacterium tuberculosis proteins
                     O07787|Rv0591|MTCY19H5.31|mce2C (481 aa);
                     O53969|Rv1968|MTV051.06|mce3C (410 aa); etc. Also highly
                     similar to others e.g. NP_302658.1|NC_002677 putative
                     secreted protein from Mycobacterium leprae (519 aa);
                     CAC12796.1|AL445327 putative secreted protein from
                     Streptomyces coelicolor (351 aa); etc. Weakly similar to
                     downstream ORF Rv0172|MTCI28.12|mce1D (530 aa), FASTA
                     score: (24.6% identity in 552 aa overlap). Contains
                     possible signal sequence and highly proline-rich
                     C-terminus. Protein product from Mb0177 detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb0177 found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MRTLEPPNRM RIGLMGIVVA LLVVAVGQSF TSVPMLFAKP SYYGQFTDSG GLHKGDRVRI
       61 AGLGVGTVEG LKIDGDHIVV KFSIGTNTIG TESRLAIRTD TILGRKVLEI EPRGAQALPP
      121 GGVLPVGQST TPYQIYDAFF DVTKAASGWD IETVKRSLNV LSETVDQTYP HLSAALDGVA
      181 KFSDTIGKRD EQITHLLAQA NQVASILGDR SDQVDRLLVN AKTLIAAFNE RGRAVDALLG
      241 NISAFSAQVQ NLINDNPNLN HVLEQLRILT DLLVDRKEDL AETLTILGRF SASFGETFAS
      301 GPYFKVLLAN LVPGQILQPF VDAAFKKRGI SPEDFWRSAG LPAYRWPDPN GTRFPNGAPP
      361 PPPPVLEGTP EHPGPAVPPG SPCSYTPPAD GLPRPWDPLP CANLTQGPFG GPDFPAPLDV
      421 ATSPPNPDGP PPAPGLPIAG RPGEVPPNVP GTPVPIPQEA PPGARTLPLG PAPGPAPPPA
      481 APGPPAPPGP GPQLPAPFIN PGGTGGSGVT GGSEN
//