LOCUS CAB5247882.1 515 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 MCE- FAMILY PROTEIN MCE1C protein. ACCESSION LT708304-181 PROTEIN_ID CAB5247882.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="mce1C" /locus_tag="BQ2027_MB0177" /note="Mb0177, mce1C, len: 515 aa. Equivalent to Rv0171, len: 515 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 515 aa overlap). mce1C; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07787|Rv0591|MTCY19H5.31|mce2C (481 aa); O53969|Rv1968|MTV051.06|mce3C (410 aa); etc. Also highly similar to others e.g. NP_302658.1|NC_002677 putative secreted protein from Mycobacterium leprae (519 aa); CAC12796.1|AL445327 putative secreted protein from Streptomyces coelicolor (351 aa); etc. Weakly similar to downstream ORF Rv0172|MTCI28.12|mce1D (530 aa), FASTA score: (24.6% identity in 552 aa overlap). Contains possible signal sequence and highly proline-rich C-terminus. Protein product from Mb0177 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb0177 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /experiment="experimental evidence, no additional details recorded" BEGIN 1 MRTLEPPNRM RIGLMGIVVA LLVVAVGQSF TSVPMLFAKP SYYGQFTDSG GLHKGDRVRI 61 AGLGVGTVEG LKIDGDHIVV KFSIGTNTIG TESRLAIRTD TILGRKVLEI EPRGAQALPP 121 GGVLPVGQST TPYQIYDAFF DVTKAASGWD IETVKRSLNV LSETVDQTYP HLSAALDGVA 181 KFSDTIGKRD EQITHLLAQA NQVASILGDR SDQVDRLLVN AKTLIAAFNE RGRAVDALLG 241 NISAFSAQVQ NLINDNPNLN HVLEQLRILT DLLVDRKEDL AETLTILGRF SASFGETFAS 301 GPYFKVLLAN LVPGQILQPF VDAAFKKRGI SPEDFWRSAG LPAYRWPDPN GTRFPNGAPP 361 PPPPVLEGTP EHPGPAVPPG SPCSYTPPAD GLPRPWDPLP CANLTQGPFG GPDFPAPLDV 421 ATSPPNPDGP PPAPGLPIAG RPGEVPPNVP GTPVPIPQEA PPGARTLPLG PAPGPAPPPA 481 APGPPAPPGP GPQLPAPFIN PGGTGGSGVT GGSEN //