LOCUS       CAB5247881.1             346 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 MCE-
            FAMILY PROTEIN MCE1B protein.
ACCESSION   LT708304-180
PROTEIN_ID  CAB5247881.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mce1B"
                     /locus_tag="BQ2027_MB0176"
                     /standard_name="mceD"
                     /note="Mb0176, mce1B, len: 346 aa. Equivalent to Rv0170,
                     len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.7% identity in 346 aa overlap). mce1B (alternate gene
                     name: mceD); belongs to 24-membered Mycobacterium
                     tuberculosis Mce protein family (see citations below for
                     more information), highly similar to Mycobacterium
                     tuberculosis proteins O07788|Rv0590|MTCY19H5.32c|mce2B
                     (275 aa); O53968|Rv1967|MTV051.05|mce3B (342 aa); etc.
                     Also highly similar to others e.g. NP_302657.1|NC_002677
                     putative secreted protein from Mycobacterium leprae (346
                     aa); CAC12797.1|AL445327 putative secreted protein from
                     Streptomyces coelicolor (354 aa); etc. Contains
                     hydrophobic region in N-terminal 30 residues. In
                     Escherichia coli, N-terminal part is functional and
                     directs export of a leaderless beta-lactamase into the
                     periplasm (see seventh citation). Protein product from
                     Mb0176 detected using shotgun mass spectrometry and SWATH
                     mass spectrometry. Mb0176 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MKITGTVVKL GIVSVVLLFF TVMIIVIFGQ MRFDRTNGYT AEFSNVSGLR QGQFVRASGV
       61 EIGKVKALHL VDGGRRVRVE FNIDRSVPLY QSTTAQIRYS DLIGNRYVEL KRGEGKGAND
      121 LLPPGGLIPL SRTSPALDLD ALIGGFKPVF RALDPAKVNN IANALITVFQ GQGGTINDTL
      181 DQTAQLTSQI AERDQAIGEV VKNLNIVLDT TVKHRKEFDE TVNNLENLIT GLRNHSDQLA
      241 GGLAHISNGA GTVADLLAEN RTLVRKAVSY LDAIQQPVID QRVELDDLLH KTPTALTALG
      301 RANGTYGDFQ NFYLCDLQIK WNGFQAGGPV RTVKLFSQPT GRCTPQ
//