LOCUS CAB5247880.1 454 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 MCE- FAMILY PROTEIN MCE1A protein. ACCESSION LT708304-179 PROTEIN_ID CAB5247880.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="mce1A" /locus_tag="BQ2027_MB0175" /standard_name="mce1" /note="Mb0175, mce1A, len: 454 aa. Equivalent to Rv0169, len: 454 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 454 aa overlap). mce1A; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07789|MCE2|Rv0589|MTCY19H5.33c|mce2A (404 aa); O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa); etc. Also highly similar to others e.g. AAD52105.1|AF113402_1|AF113402 mycobacterial cell entry protein from Mycobacterium bovis BCG (454 aa); NP_302656.1|NC_002677 putative cell invasion protein from Mycobacterium leprae (441 aa); AAA92845.1|U26018 mce gene product from Mycobacterium avium (88 aa) (similarity on C-terminus); CAC12798.1|AL445327 putative secreted protein from Streptomyces coelicolor (418 aa); etc. Note that equivalent, but longer 22 aa, to P72013|CAA50257.1|X70901 Mcep protein from Mycobacterium tuberculosis (432 aa). Contains a very hydrophobic region around residues 20-35. Note that previously known as mce1. Protein product from Mb0175 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb0175 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /experiment="experimental evidence, no additional details recorded" BEGIN 1 MTTPGKLNKA RVPPYKTAGL GLVLVFALVV ALVYLQFRGE FTPKTQLTML SARAGLVMDP 61 GSKVTYNGVE IGRVDTISEV TRDGESAAKF ILDVDPRYIH LIPANVNADI KATTVFGGKY 121 VSLTTPKNPT KRRITPKDVI DVRSVTTEIN TLFQTLTSIA EKVDPVKLNL TLSAAAEALT 181 GLGDKFGESI VNANTVLDDL NSRMPQSRHD IQQLAALGDV YADAAPDLFD FLDSSVTTAR 241 TINAQQAELD SALLAAAGFG NTTADVFDRG GPYLQRGVAD LVPTATLLDT YSPELFCTIR 301 NFYDADPLAK AAAGGGNGYS LRTNSEILSG IGISLLSPLA LATNGAAIGI GLVAGLIASP 361 LAVAANLAGA LPGIVGGAPN PYTYPENLPR VNARGGPGGA PGCWQPITRD LWPAPYLVMD 421 TGASLAPYNH MEVGSPYAVE YVWGRQVGDN TINP //