LOCUS       CAB5247880.1             454 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 MCE-
            FAMILY PROTEIN MCE1A protein.
ACCESSION   LT708304-179
PROTEIN_ID  CAB5247880.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mce1A"
                     /locus_tag="BQ2027_MB0175"
                     /standard_name="mce1"
                     /note="Mb0175, mce1A, len: 454 aa. Equivalent to Rv0169,
                     len: 454 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.6% identity in 454 aa overlap). mce1A; belongs to
                     24-membered Mycobacterium tuberculosis Mce protein family
                     (see citations below for more information), highly similar
                     to Mycobacterium tuberculosis proteins
                     O07789|MCE2|Rv0589|MTCY19H5.33c|mce2A (404 aa);
                     O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa); etc. Also
                     highly similar to others e.g.
                     AAD52105.1|AF113402_1|AF113402 mycobacterial cell entry
                     protein from Mycobacterium bovis BCG (454 aa);
                     NP_302656.1|NC_002677 putative cell invasion protein from
                     Mycobacterium leprae (441 aa); AAA92845.1|U26018 mce gene
                     product from Mycobacterium avium (88 aa) (similarity on
                     C-terminus); CAC12798.1|AL445327 putative secreted protein
                     from Streptomyces coelicolor (418 aa); etc. Note that
                     equivalent, but longer 22 aa, to P72013|CAA50257.1|X70901
                     Mcep protein from Mycobacterium tuberculosis (432 aa).
                     Contains a very hydrophobic region around residues 20-35.
                     Note that previously known as mce1. Protein product from
                     Mb0175 detected using shotgun mass spectrometry and SWATH
                     mass spectrometry. Mb0175 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MTTPGKLNKA RVPPYKTAGL GLVLVFALVV ALVYLQFRGE FTPKTQLTML SARAGLVMDP
       61 GSKVTYNGVE IGRVDTISEV TRDGESAAKF ILDVDPRYIH LIPANVNADI KATTVFGGKY
      121 VSLTTPKNPT KRRITPKDVI DVRSVTTEIN TLFQTLTSIA EKVDPVKLNL TLSAAAEALT
      181 GLGDKFGESI VNANTVLDDL NSRMPQSRHD IQQLAALGDV YADAAPDLFD FLDSSVTTAR
      241 TINAQQAELD SALLAAAGFG NTTADVFDRG GPYLQRGVAD LVPTATLLDT YSPELFCTIR
      301 NFYDADPLAK AAAGGGNGYS LRTNSEILSG IGISLLSPLA LATNGAAIGI GLVAGLIASP
      361 LAVAANLAGA LPGIVGGAPN PYTYPENLPR VNARGGPGGA PGCWQPITRD LWPAPYLVMD
      421 TGASLAPYNH MEVGSPYAVE YVWGRQVGDN TINP
//