LOCUS CAB5247879.1 289 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 conserved integral membrane protein yrbe1b protein. ACCESSION LT708304-178 PROTEIN_ID CAB5247879.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="yrbE1B" /locus_tag="BQ2027_MB0174" /note="Mb0174, yrbE1B, len: 289 aa. Equivalent to Rv0168, len: 289 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 289 aa overlap). yrbE1B, hypothetical unknown integral membrane protein, part of mce1 operon and member of YrbE family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07790|Rv0588|MTCY19H5.34|yrbE2B (295 aa); O53966|Rv1965|MTV051.03|yrbE3B (271 aa); etc. Also highly similar to conserved hypothetical integral membrane proteins of the yrbEB type, e.g. NP_302655.1|NC_002677 conserved membrane protein from Mycobacterium leprae (289 aa); P45030|YRBE_HAEIN|HI1086 hypothetical protein from Haemophilus influenzae (261 aa), FASTA scores: opt: 223, E(): 7.6e-07, (23.7% identity in 257 aa overlap); etc. Mb0174 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." BEGIN 1 MSTAAVLRAR FPRAVANLRQ YGGAAARGLD EAGQLTWFAL TSIGQIAHAL RYYRKETLRL 61 IAQIGMGTGA MAVVGGTVAI VGFVTLSGSS LVAIQGFASL GNIGVEAFTG FFAALINVRI 121 AGPVVTGVAL AATVGAGATA ELGAMRISEE IDALEVMGIK SISFLASTRI MAGLVVIIPL 181 YALAMIMSFL SPQITTTVLY GQSNGTYEHY FQTFLRPDDV FWSFLEALII TAIVMVSHCY 241 YGYAAGGGPV GVGEAVGRSM RFSLVSVQVV VLFAALALYG VDPNFNLTV //