LOCUS CAB5247878.1 265 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 conserved integral membrane protein yrbe1a protein. ACCESSION LT708304-177 PROTEIN_ID CAB5247878.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="yrbE1A" /locus_tag="BQ2027_MB0173" /note="Mb0173, yrbE1A, len: 265 aa. Equivalent to Rv0167, len: 265 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 265 aa overlap). yrbE1A, hypothetical unknown integral membrane protein, part of mce1 operon and member of YrbE family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa); O53965|Rv1964|MTV051.02|yrbE3A (265 aa); etc. Also highly similar or similar to conserved hypothetical integral membrane proteins of yrbEA type, e.g. NP_302654.1|NC_002677 conserved membrane protein from Mycobacterium leprae (267 aa); P45030|YRBE_HAEIN|HI1086 hypothetical protein from Haemophilus influenzae (261 aa), FASTA scores: opt: 328, E(): 1.8e-15, (26.6% identity in 244 aa overlap); etc. Protein product from Mb0173 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb0173 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." BEGIN 1 MTTSTTLGGY VRDQLQTPLT LVGGFFRMCV LTGKALFRWP FQWREFILQC WFIMRVGFLP 61 TIMVSIPLTV LLIFTLNILL AQFGAADISG SGAAIGAVTQ LGPLTTVLVV AGAGSTAICA 121 DLGARTIREE IDAMEVLGID PIHRLVVPRV LASMLVATLL NGLVITVGLV GGFLFGVYLQ 181 NVSGGAYLAT LTLITGLPEV VIATIKAATF GLIAGLVGCY RGLTVRGGSK GLGTAVNETV 241 VLCVIALFAV NVILTTIGVR FGTGR //