LOCUS       CAB5247878.1             265 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 conserved
            integral membrane protein yrbe1a protein.
ACCESSION   LT708304-177
PROTEIN_ID  CAB5247878.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="yrbE1A"
                     /locus_tag="BQ2027_MB0173"
                     /note="Mb0173, yrbE1A, len: 265 aa. Equivalent to Rv0167,
                     len: 265 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 265 aa overlap). yrbE1A, hypothetical
                     unknown integral membrane protein, part of mce1 operon and
                     member of YrbE family (see citations below for more
                     information), highly similar to Mycobacterium tuberculosis
                     proteins O07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa);
                     O53965|Rv1964|MTV051.02|yrbE3A (265 aa); etc. Also highly
                     similar or similar to conserved hypothetical integral
                     membrane proteins of yrbEA type, e.g.
                     NP_302654.1|NC_002677 conserved membrane protein from
                     Mycobacterium leprae (267 aa); P45030|YRBE_HAEIN|HI1086
                     hypothetical protein from Haemophilus influenzae (261 aa),
                     FASTA scores: opt: 328, E(): 1.8e-15, (26.6% identity in
                     244 aa overlap); etc. Protein product from Mb0173 detected
                     using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb0173 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
BEGIN
        1 MTTSTTLGGY VRDQLQTPLT LVGGFFRMCV LTGKALFRWP FQWREFILQC WFIMRVGFLP
       61 TIMVSIPLTV LLIFTLNILL AQFGAADISG SGAAIGAVTQ LGPLTTVLVV AGAGSTAICA
      121 DLGARTIREE IDAMEVLGID PIHRLVVPRV LASMLVATLL NGLVITVGLV GGFLFGVYLQ
      181 NVSGGAYLAT LTLITGLPEV VIATIKAATF GLIAGLVGCY RGLTVRGGSK GLGTAVNETV
      241 VLCVIALFAV NVILTTIGVR FGTGR
//