LOCUS       CAB5247877.1             554 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            FATTY-ACID-CoA LIGASE FADD5 (FATTY-ACID-CoA SYNTHETASE)
            (FATTY-ACID-CoA SYNTHASE) protein.
ACCESSION   LT708304-176
PROTEIN_ID  CAB5247877.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="fadD5"
                     /locus_tag="BQ2027_MB0172"
                     /note="Mb0172, fadD5, len: 554 aa. Equivalent to Rv0166,
                     len: 554 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.6% identity in 554 aa overlap). Probable fadD5,
                     fatty-acid-CoA synthetase (EC 6.2.1.-), similar to many eg
                     LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase (561
                     aa), FASTA scores: opt: 612, E(): 0, (29.4% identity in
                     534 aa overlap). Also similar to many other fatty-acid-CoA
                     ligases from Mycobacterium tuberculosis e.g. MTCY07A7.11c
                     FASTA score: (35.3% identity in 487 aa overlap),
                     MTV013_10, MTY25D10_30, etc. Contains PS00455 putative
                     AMP-binding domain signature. Protein product from Mb0172
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb0172 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MTAQLASHLT RALTLAQQQP YLARRQNWVN QLERHAMMQP DAPALRFVGN TMTWADLRRR
       61 VAALAGALSG RGVGFGDRVM ILMLNRTEFV ESVLAANMIG AIAVPLNFRL TPTEIAVLVE
      121 DCAAHVMLTE AALAPVAIGV RNIQPLLSVI VVAGGSSQDS VFGYEDLLNE AGDVHEPVDI
      181 PNDSPALIMY TAGTTGRPKG AVLTHANLTG QAMTALYTSG ANINSDVGFV GVPLFHIAGI
      241 GNMLTGLLLG LPTVIYPLGA FDPGQLLDVL EAEKVTGIFL VPAQWQAVCT EQQARPRDLR
      301 LRVLSWGAAP APDALLRQMS ATFPETQILA AFGQTEMSPV TCMLLGEDAI AKRGSVGRVI
      361 PTVAARVVDQ NMNDVPVGEV GEIVYRAPTL MSCYWNNPEA TAEAFAGGWF HSGDLVRMDS
      421 DGYVWVVDRK KDMIISGGEN IYCAELENVL ASHPDIAEVA VIGRADEKWG EVPIAVAAVT
      481 NDDLRIEDLG EFLTDRLARY KHPKALEIVD ALPRNPAGKV LKTELRLRYG ACVNVERRSA
      541 SAGFTERREN RQKL
//