LOCUS       CAB5247876.1             230 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Probable
            transcriptional regulatory protein Mce1R (probably GntR-
            family) protein.
ACCESSION   LT708304-175
PROTEIN_ID  CAB5247876.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mce1r"
                     /locus_tag="BQ2027_MB0170C"
                     /note="Mb0170c, len: 230 aa. Equivalent to Rv0165c len:
                     223 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (81.2% identity in 218 aa overlap). Probable
                     mce1R,transcriptional regulator, GntR family (See Casali
                     et al.,2006), showing some similarity to several e.g.
                     NTRA_CHELE|P54988 nta operon transcriptional regulator
                     (231 aa), FASTA scores: opt: 154, E(): 0.00058, (32.0%
                     identity in 125 aa overlap); P46833|GNTR_BACLI gluconate
                     operon transcriptional repressor from Bacillus
                     licheniformis (243 aa); GNTR_BACSU gluconate operon
                     repressor from Bacillus subtilis (243 aa). Also similar to
                     Rv0043c from Mycobacterium tuberculosis. Seems to belong
                     to the GntR family of transcriptional regulators. Start
                     changed since first submission (-41 aa).
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium
                     tuberculosis strain H37Rv, Rv0165c exists as a single
                     gene. In Mycobacterium bovis, a frameshift due to a 2 bp
                     insertion (*-cc) leads to a product with a different COOH
                     terminus. Mb0170c found to be expressed during exponential
                     growth in Sauton's minimal media by RNA-sequencing."
BEGIN
        1 MNAPLSAKPR SQLPLRRAQL SDEVAGHLRA AIMSGALRSG TFIRLDETAA ELGVSVTPVR
       61 EALLKLRGEG MVGLEPHRGH VVLPLTRQDI DDIFWLQATI AQELATSATA HITDVEIDEL
      121 DRINNALAGA IGSGDAKTIA SIEFAFHRVF NKASRRIKLA WFLLNAARYM PAQVFAADPR
      181 WGADAVNSHR QLIAALRRRD TAAVIEHTVW QFTDGARRLT EALAETEVFG
//