LOCUS CAB5247876.1 230 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 Probable transcriptional regulatory protein Mce1R (probably GntR- family) protein. ACCESSION LT708304-175 PROTEIN_ID CAB5247876.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="mce1r" /locus_tag="BQ2027_MB0170C" /note="Mb0170c, len: 230 aa. Equivalent to Rv0165c len: 223 aa, from Mycobacterium tuberculosis strain H37Rv, (81.2% identity in 218 aa overlap). Probable mce1R,transcriptional regulator, GntR family (See Casali et al.,2006), showing some similarity to several e.g. NTRA_CHELE|P54988 nta operon transcriptional regulator (231 aa), FASTA scores: opt: 154, E(): 0.00058, (32.0% identity in 125 aa overlap); P46833|GNTR_BACLI gluconate operon transcriptional repressor from Bacillus licheniformis (243 aa); GNTR_BACSU gluconate operon repressor from Bacillus subtilis (243 aa). Also similar to Rv0043c from Mycobacterium tuberculosis. Seems to belong to the GntR family of transcriptional regulators. Start changed since first submission (-41 aa). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0165c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp insertion (*-cc) leads to a product with a different COOH terminus. Mb0170c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." BEGIN 1 MNAPLSAKPR SQLPLRRAQL SDEVAGHLRA AIMSGALRSG TFIRLDETAA ELGVSVTPVR 61 EALLKLRGEG MVGLEPHRGH VVLPLTRQDI DDIFWLQATI AQELATSATA HITDVEIDEL 121 DRINNALAGA IGSGDAKTIA SIEFAFHRVF NKASRRIKLA WFLLNAARYM PAQVFAADPR 181 WGADAVNSHR QLIAALRRRD TAAVIEHTVW QFTDGARRLT EALAETEVFG //