LOCUS       CAB5247873.1             383 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            zinc-type alcohol dehydrogenase (e subunit) adhe1 protein.
ACCESSION   LT708304-172
PROTEIN_ID  CAB5247873.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="adhE1"
                     /locus_tag="BQ2027_MB0167C"
                     /note="Mb0167c, adhE1, len: 383 aa. Equivalent to Rv0162c,
                     len: 383 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 383 aa overlap). Probable adhE1,
                     zinc-type alcohol dehydrogenase (EC 1.1.1.1), similar to
                     others e.g. ADH_MACMU|P28469 alcohol dehydrogenase alpha
                     chain (374 aa), FASTA scores: opt: 619, E(): 0, (34.7%
                     identity in 363 aa overlap). Also similar to other alcohol
                     dehydrogenases from Mycobacterium tuberculosis e.g.
                     MTCY369.06c FASTA score: (34.0% identity in 365 aa
                     overlap), MTV022_9 FASTA score: (35.0% identity in 371 aa
                     overlap). Contains PS00059 Zinc-contain ingalcohol
                     dehydrogenases signature. BELONGS TO THE ZINC-CONTAINING
                     ALCOHOL DEHYDROGENASE FAMILY, CLASS-I SUBFAMILY. COFACTOR:
                     ZINC. Protein product from Mb0167c detected using SWATH
                     mass spectrometry. Mb0167c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
BEGIN
        1 MPAVQPWLYS NMPAIRGAVL DQIGVPRPYW RSKPISVVEL HLDPPDRGEV LVRIEAAGVC
       61 HSDLSVVDGT RVRPVPILLG HEAAGIVEQV GDGVDGVAVG QRVVLVFLPR CGQCAACATD
      121 GRTPCEPGSA ANKAGTLLGG GIRLSRGGRP VYHHLGVSGF ATHVVVNRAS VVPVPHEVPP
      181 TVAALLGCAV LTGGGAVLNV GDPQPGQSVA VVGLGGVGMA AVLTALTYTD VRVVAVDQLP
      241 EKLSAAKALG AHEIYTPQQA TAGGVKAAVV VEAVGHPAAL HTAIGLTAPG GRTITVGLPP
      301 PDVRISLSPL DFVTEGRSLI GSYLGSAVPS HDIPRFVSLW QSGRLPVESL VTSTIRLDDI
      361 NEAMDHLADG IAVRQLISFT GDL
//