LOCUS       CAB5247863.1             276 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PHOSPHOTYROSINE
            PROTEIN PHOSPHATASE PTPB (PROTEIN-TYROSINE-PHOSPHATASE)
            (PTPase) protein.
ACCESSION   LT708304-162
PROTEIN_ID  CAB5247863.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="ptbB"
                     /locus_tag="BQ2027_MB0158C"
                     /standard_name="MPtpB"
                     /note="Mb0158c, ptbB, len: 276 aa. Equivalent to Rv0153c,
                     len: 276 aa, from Mycobacterium tuberculosis strain H27Rv,
                     (99.6% identity in 276 aa overlap). ptbB (alternate gene
                     name: MPtpB), protein-tyrosine-phosphatase (see citation
                     below) (EC 3.1.3.48), showing some similarity to several
                     protein-tyrosine phosphatases, polyketide synthase and
                     aminotransferase e.g. Q05918|IPHP_NOSCO|IPH
                     PROTEIN-TYROSINE-PHOSPHATASE PRECURSOR from Nostoc commune
                     (EC 3.1.3.48) (294 aa), FASTA scores: opt: 150, E():
                     0.0096, (26.8% identity in 269 aa overlap); etc. Supposed
                     a secreted protein. Protein product from Mb0158c detected
                     using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb0158c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MAVRELPGAW NFRDVADTAT ALRPGRLFRS SELSRLDDAG RATLRRLGIT DVADLRSSRE
       61 VARRGPGRVP DGIDVHLLPF PDLADDDADD SAPHETAFKR LLTNGGSNGE SGESSQSIND
      121 AATRYMTDEY RQFPTRNGAQ RALHRVVTLL AAGRPVLTHC FAGKDRTGFV VALVLEAVGL
      181 DRDVIVADYL RSNDSVPQLR ARISEMIQQR FDTELAPEVV TFTKARLSDG VLGVRAEYLA
      241 AARQTIDETY GSLGGYLRDA GISQATVNRM RGVLLG
//