LOCUS CAB5247863.1 276 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB (PROTEIN-TYROSINE-PHOSPHATASE) (PTPase) protein. ACCESSION LT708304-162 PROTEIN_ID CAB5247863.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="ptbB" /locus_tag="BQ2027_MB0158C" /standard_name="MPtpB" /note="Mb0158c, ptbB, len: 276 aa. Equivalent to Rv0153c, len: 276 aa, from Mycobacterium tuberculosis strain H27Rv, (99.6% identity in 276 aa overlap). ptbB (alternate gene name: MPtpB), protein-tyrosine-phosphatase (see citation below) (EC 3.1.3.48), showing some similarity to several protein-tyrosine phosphatases, polyketide synthase and aminotransferase e.g. Q05918|IPHP_NOSCO|IPH PROTEIN-TYROSINE-PHOSPHATASE PRECURSOR from Nostoc commune (EC 3.1.3.48) (294 aa), FASTA scores: opt: 150, E(): 0.0096, (26.8% identity in 269 aa overlap); etc. Supposed a secreted protein. Protein product from Mb0158c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb0158c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /experiment="experimental evidence, no additional details recorded" BEGIN 1 MAVRELPGAW NFRDVADTAT ALRPGRLFRS SELSRLDDAG RATLRRLGIT DVADLRSSRE 61 VARRGPGRVP DGIDVHLLPF PDLADDDADD SAPHETAFKR LLTNGGSNGE SGESSQSIND 121 AATRYMTDEY RQFPTRNGAQ RALHRVVTLL AAGRPVLTHC FAGKDRTGFV VALVLEAVGL 181 DRDVIVADYL RSNDSVPQLR ARISEMIQQR FDTELAPEVV TFTKARLSDG VLGVRAEYLA 241 AARQTIDETY GSLGGYLRDA GISQATVNRM RGVLLG //