LOCUS       CAB5247859.1             322 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 possible
            quinone oxidoreductase (nadph:quinone oxidoreductase)
            (zeta-crystallin) protein.
ACCESSION   LT708304-158
PROTEIN_ID  CAB5247859.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0154"
                     /note="Mb0154, -, len: 322 aa. Equivalent to Rv0149, len:
                     322 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 322 aa overlap). Putative quinone
                     oxidoreductase (EC 1.6.5.-), similar to others
                     oxidoreductases e.g. Q08257 quinone oxidoreductase (EC
                     1.6.5.5) (329 aa), FASTA scores: opt: 397, E(): 3.2e-18,
                     (28.4% identity in 328 aa overlap); SCHCOADH_4 from
                     Streptomyces coelicolor. Also similar to many proteins
                     from Mycobacterium tuberculosis. Contains PS01162 Quinone
                     oxidoreductase / zeta-crystallin signature. BELONG TO THE
                     ZINC-CONTAINING ALCOHOL DEHYDROGENASE FAMILY, QUINONE
                     OXIDOREDUCTASE SUBFAMILY. Protein product from Mb0154
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb0154 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
BEGIN
        1 MKACVVKELS GPSGMVYTDI DEVSGDGGKV VIDVRAAGVC FPDLLLTKGE YQLKLTPPFV
       61 PGMETAGVVR SAPSDAGFHV GERVSAFGVL GGYAEQIAVP VANVVRSPVE LDDAGAVSLL
      121 VNYNTMYFAL ARRAALRPGD TVLVLGAAGG VGTAAVQIAK AMQAGKVIAM VHREGAIDYV
      181 ASLGADVVLP LTEGWAQQVR DHTYGQGVDI VVDPIGGPTF DDALGVLAID GKLLLIGFAA
      241 GAVPTLKVNR LLVRNISVVG VGWGEYLNAV PGSAALFAWG LNQLVFLGLR PPPPQRYPLS
      301 EAQAALQSLD DGGVLGKVVL EP
//