LOCUS       CAB5247857.1             506 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            aldehyde dehydrogenase (nad+) dependent protein.
ACCESSION   LT708304-156
PROTEIN_ID  CAB5247857.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0152"
                     /note="Mb0152, -, len: 506 aa. Equivalent to Rv0147, len:
                     506 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 506 aa overlap). Probable aldehyde
                     dehydrogenase (NAD+) dependant (EC 1.2.1.-), similar to
                     others e.g. DHAP_RAT|P11883 aldehyde dehydrogenase
                     (dimeric NADP-preferring) (452 aa), FASTA scores: opt:
                     1291, E(): 0, (43.9% identity in 453 aa overlap). Also
                     similar to several Mycobacterium tuberculosis aledehyde
                     dehydrogenases e.g. Rv0768, Rv2858c, etc. Contains PS00687
                     aldehyde dehydrogenases glutamic acid active site, and
                     PS00070 aldehyde dehydrogenases cysteine active site.
                     BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY. Protein
                     product from Mb0152 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb0152 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
BEGIN
        1 MSDRVKAVAP PDGRTMMTTE SVARKTQKSE TEAPREPAPV SDEKQTDVAK TVARLRKTFA
       61 SGRTRSVEWR KQQLRALQKL MDENEDAIAA ALAEDLDRNP FEAYLADIAT TSAEAKYAAK
      121 RVRRWMRRRY LLLEVPQLPG RGWVEYEPYG TVLIIGAWNY PFYLTLGPAV GAIAAGNAVV
      181 LKPSEIAAAS AHLMTELVYR YLDTEAIAVV QGDGAVSQEL IAQGFDRVMF TGGTEIGRKV
      241 YEGAAPHLTP VTLELGGKSP VIVAADADVD VAAKRIAWIK LLNAGQTCVA PDYVLADATV
      301 RDELVSKITA ALTKFRSGAP QGMRIVNQRQ FDRLSGYLAA AKTDAAADGG GVVVGGDCDA
      361 SNLRIQPTVV VDPDPDGPLM SNEIFGPILP VVTVKSLDDA IRFVNSRPKP LSAYLFTKSR
      421 AVRERVIREV PAGGMMVNHL AFQVSTAKLP FGGVGASGMG AYHGRWGFEE FSHRKSVLTK
      481 PTRPDLSSFI YPPYTERAIK VARRLF
//