LOCUS       CAB5247854.1             280 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY TETR-FAMILY)
            protein.
ACCESSION   LT708304-153
PROTEIN_ID  CAB5247854.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0149"
                     /note="Mb0149, -, len: 280 aa. Equivalent to Rv0144, len:
                     280 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 280 aa overlap). Probable
                     transcriptional regulator, possibly tetR family. Has
                     region similar to others e.g.
                     Q59431|UIDR_ECOLI|GUSR|B1618|Z2623|ECS2326 UID OPERON
                     REPRESSOR (GUS OPERON) from Escherichia coli strains K12
                     and O157:H7 (196 aa), FASTA scores: opt: 214, E():
                     1.1e-06, (26.0% identity in 196 aa overlap). Contains
                     probable helix-turn helix motif from aa 109-130 (Score
                     1463, +4.17 SD). COULD BELONG TO THE TETR/ACRR FAMILY OF
                     TRANSCRIPTIONAL REGULATORS. Protein product from Mb0149
                     detected using shotgun mass spectrometry. Mb0149 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
BEGIN
        1 MPHSWTPTSV MTPPLVVAAF RPVGHYRLAT DRAGGPCSPP ATGAKLTSSV ASRPTVGTKP
       61 QWWHTLVMSM SLTAGRGPGR PPAAKADETR KRILHAARQV FSERGYDGAT FQEIAVRADL
      121 TRPAINHYFA NKRVLYQEVV EQTHELVIVA GIERARREPT LMGRLAVVVD FAMEADAQYP
      181 ASTAFLATTV LESQRHPELS RTENDAVRAT REFLVWAVND AIERGELAAD VDVSSLAETL
      241 LVVLCGVGFY IGFVGSYQRM ATITDSFQQL LAGTLWRPPT
//