LOCUS       CAB5247853.1             492 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CONSERVED TRANSMEMBRANE PROTEIN protein.
ACCESSION   LT708304-152
PROTEIN_ID  CAB5247853.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0148C"
                     /note="Mb0148c, -, len: 492 aa. Equivalent to Rv0143c,
                     len: 492 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 492 aa overlap). Probable conserved
                     transmembrane protein, CIC family possibly involved in
                     transport of chloride, similar to others and hypothetical
                     proteins e.g. O28857 PUTATIVE CHLORIDE CHANNEL from
                     Archaeoglobus fulgidus (589 aa), FASTA scores: opt: 966,
                     E(): 0, (37.7% identity in 453 aa overlap);
                     YADQ_ECOLI|P37019 hypothetical 46.0 kd protein (436 aa),
                     FASTA scores: opt: 452, E(): 2.4e-20, (28.0% identity in
                     460 aa overlap). Protein product from Mb0148c detected
                     using SWATH mass spectrometry. Mb0148c found to be
                     expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
BEGIN
        1 MAPGDWSVFA WHAANLPTMP EAEDIGNEAA GGRLGVSIRS AGYLRKWFLL GITIGVIAGL
       61 GAVVFYLALK YTSEFLLGYL ADYQIPTPVG EGGHRGSTGF ARPWAIPLVT TGGAVLSALI
      121 VAKLAPEATG HGTDEAIESV HGDPRAIRGR AVLVKMVASA LTIGSGGSGG REGPTAQISA
      181 GFCSLLTRRL NLSNEDGRTA VALGIGAGIG AIFAAPLGGA ALGASIPYRD DFDYRNLLPG
      241 FIASGTAYAV LGAFLGFDPL FGYIDAEYRF EKAWPLLWFV VIGLIAAAVG YLYARVFHAS
      301 VAITRRLPGG PVLKPAIGGL LVGLLGLPIP QILSSGYGWA QLAADRGTLL SIPLWIVIVL
      361 PIAKILATSL SIGTGGSGGL FGPGIVIGAF VGAAIWRLGE LTELPGVPHE PGIFVVVAMM
      421 ACFGSVSRAP LAVMIMVAEM TGSFSVVPGA IIAVGIAALL LSRTNVTIYE TQRLNRQTAE
      481 AERGGSDRPT TA
//