LOCUS       CAB5247846.1             441 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CYTOCHROME P450 138 CYP138 protein.
ACCESSION   LT708304-145
PROTEIN_ID  CAB5247846.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="cyp138"
                     /locus_tag="BQ2027_MB0141"
                     /note="Mb0141, cyp138, len: 441 aa. Equivalent to Rv0136,
                     len: 441 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 441 aa overlap). Probable cyp138,
                     cytochrome P450 138 (EC 1.14.-.-), similar to others e.g.
                     SLR0574|Q59990 from SYNECHOCYSTIS SP. (444 aa), FASTA
                     scores: opt: 315, E(): 1e-13, (25.7% identity in 416 aa
                     overlap); etc. Also similar to MTV039_6 from Mycobacterium
                     tuberculosis (472 aa), FASTA score: (38.2% identity in 442
                     aa overlap). Contains PS00017 ATP/GTP-binding site motif A
                     (P-loop); and PS00086 Cytochrome P450 cysteine heme-iron
                     ligand signature. BELONGS TO THE CYTOCHROME P450 FAMILY.
                     Protein product from Mb0141 detected using SWATH mass
                     spectrometry. Mb0141 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
BEGIN
        1 MSEVVTAAPA PPVVRLPPAV RGPKLFQGLA FVVSRRRLLG RFVRRYGKAF TANILMYGRV
       61 VVVADPQLAR QVFTSSPEEL GNIQPNLSRM FGSGSVFALD GDDHRRRRRL LAPPFHGKSM
      121 KNYETIIEEE TLRETANWPQ GQAFATLPSM MHITLNAILR AIFGAGGSEL DELRRLIPPW
      181 VTLGSRLAAL PKPKRDYGRL SPWGRLAEWR RQYDTVIDKL IEAERADPNF ADRTDVLALM
      241 LRSTYDDGSI MSRKDIGDEL LTLLAAGHET TAATLGWAFE RLSRHPDVLA ALVEEVDNGG
      301 HELRQAAILE VQRARTVIDF AARRVNPPVY QLGEWVIPRG YSIIINIAQI HGDPDVFPQP
      361 DRFDPQRYIG SKPSPFAWIP FGGGTRRCVG AAFANMEMDV VLRTVLRHFT LETTTAAGER
      421 SHGRGVAFTP KDGGRVVMRR R
//