LOCUS       CAB5247836.1             340 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 SECRETED
            ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C)
            (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN
            C) protein.
ACCESSION   LT708304-135
PROTEIN_ID  CAB5247836.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="fbpC"
                     /locus_tag="BQ2027_MB0134C"
                     /standard_name="mpt45; 85C; fbpC2"
                     /note="Mb0134c, fbpC, len: 340 aa. Equivalent to Rv0129c,
                     len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 340 aa overlap). fbpC (alternate gene
                     names: mpt45, 85C, fbpC2), secreted antigen 85c
                     (fibronectin-binding protein C) (mycolyl transferase 85C)
                     (EC 2.3.1.-) (see citations below), also highly similar to
                     other Mycobacterial antigen precursors e.g.
                     A85C_MYCLE|Q05862 antigen 85-c precursor (85c) from
                     Mycobacterium leprae (333 aa), FASTA scores: opt: 1937,
                     E(): 0, (81.4% identity in 333 aa overlap); etc. Protein
                     product from Mb0134c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb0134c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MTFFEQVRRL RSAATTLPRR LAIAAMGAVL VYGLVGTFGG PATAGAFSRP GLPVEYLQVP
       61 SASMGRDIKV QFQGGGPHAV YLLDGLRAQD DYNGWDINTP AFEEYYQSGL SVIMPVGGQS
      121 SFYTDWYQPS QSNGQNYTYK WETFLTREMP AWLQANKGVS PTGNAAVGLS MSGGSALILA
      181 AYYPQQFPYA ASLSGFLNPS EGWWPTLIGL AMNDSGGYNA NSMWGPSSDP AWKRNDPMVQ
      241 IPRLVANNTR IWVYCGNGTP SDLGGDNIPA KFLEGLTLRT NQTFRDTYAA DGGRNGVFNF
      301 PPNGTHSWPY WNEQLVAMKA DIQHVLNGAT PPAAPAAPAA
//