LOCUS       CAB5247833.1             601 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 TREHALOSE
            SYNTHASE TRES protein.
ACCESSION   LT708304-132
PROTEIN_ID  CAB5247833.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="treS"
                     /locus_tag="BQ2027_MB0131"
                     /note="Mb0131, treS, len: 601 aa. Equivalent to Rv0126,
                     len: 601 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 601 aa overlap). treS, trehalose
                     synthase (EC 5.4.99.-) (see citation below), highly
                     similar to others e.g. CAA04601.2|AJ001205 putative
                     trehalose synthase from Streptomyces coelicolor (566 aa);
                     S71450|1536814|BAA11303.1|D78198 trehalose synthase
                     maltose-specific from Pimelobacter sp. strain R48 (573
                     aa). Also similar to MAL1_DROME|P07191 possible maltase
                     precursor (508 aa), FASTA scores: opt: 807, E(): 0, (33.7%
                     identity in 504 aa overlap); and similar to proteins
                     associated with amino-acid transport e.g. Q64319 rat
                     protein which stimulates transport of cystine and dibasic
                     and neutral amino acids (683 aa), FASTA scores: opt: 839,
                     E(): 0, (32.0% identity in 531 aa overlap). Also similar
                     to several other Mycobacterium tuberculosis proteins e.g.
                     Rv2471 FASTA score: (31.7% identity in 164 aa overlap).
                     Protein product from Mb0131 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb0131 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MNEAEHSVEH PPVQGSHVEG GVVEHPDAKD FGSAAALPAD PTWFKHAVFY EVLVRAFFDA
       61 SADGSGDLRG LIDRLDYLQW LGIDCIWLPP FYDSPLRDGG YDIRDFYKVL PEFGTVDDFV
      121 ALVDAAHRRG IRIITDLVMN HTSESHPWFQ ESRRDPDGPY GDYYVWSDTS ERYTDARIIF
      181 VDTEESNWSF DPVRRQFYWH RFFSHQPDLN YDNPAVQEAM IDVIRFWLGL GIDGFRLDAV
      241 PYLFEREGTN CENLPETHAF LKRVRKVVDD EFPGRVLLAE ANQWPGDVVE YFGDPNTGGD
      301 ECHMAFHFPL MPRIFMAVRR ESRFPISEII AQTPPIPDMA QWGIFLRNHD ELTLEMVTDE
      361 ERDYMYAEYA KDPRMKANVG IRRRLAPLLD NDRNQIELFT ALLLSLPGSP VLYYGDEIGM
      421 GDVIWLGDRD GVRIPMQWTP DRNAGFSTAN PGRLYLPPSQ DPVYGYQAVN VEAQRDTSTS
      481 LLNFTRTMLA VRRRHPAFAV GAFQELGGSN PSVLAYVRQV AGDDGDTVLC VNNLSRFPQP
      541 IELDLQQWTN YTPVELTGHV EFPRIGQVPY LLTLPGHGFY WFQLTTHEVG APPTCGGERR
      601 L
//