LOCUS CAB5247824.1 582 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE OXALYL-COA DECARBOXYLASE OXCA protein. ACCESSION LT708304-123 PROTEIN_ID CAB5247824.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="oxcA" /locus_tag="BQ2027_MB0122C" /note="Mb0122c, oxcA, len: 582 aa. Equivalent to Rv0118c, len: 582 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 582 aa overlap). Probable oxcA, oxalyl-CoA decarboxylase (EC 4.1.1.8), highly similar to many e.g. P78093|OXC_ECOLI|7449483|B65011|YFDU|B2373|Z3637 |ECS325 PROBABLE OXALYL-CoA DECARBOXYLASE from Escherichia coli (564 aa); M77128|OXAOXA_1 oxalyl-CoA decarboxylase from Oxalobacter formigenes (568 aa), FASTA scores: opt: 2124, E():0, (55.6% identity in 568 aa overlap). Also similar to mycobacterial IlvB proteins e.g. MLCB1788.46c unknown TPP-requiring enzyme from Mycobacterium leprae (548 aa); and AL0086|MLCB1788_19 from Mycobacterium leprae (548 aa), FASTA scores: opt: 831, E(): 0, (33.9% identity in 567 aa overlap). Protein product from Mb0122c detected using shotgun mass spectrometry and SWATH mass spectrometry." BEGIN 1 MTTRSASPCT VLTDGCHLVV DALKANDVDT IYGVVGIPIT DLARAAQASG IRYIGFRHEA 61 SAGNAAAAAG FLTARPGVCL TTSGPGFLNG LPALANATTN CFPMIQISGS SSRPMVDLQR 121 GDYQDLDQLN AARPFVKAAY RIGQVQDIGR GVARAIRTAT SGRPGGVYLD IPGDVLGQAV 181 EASAASGAIW RPVDPAPRLL PAPEAIDRAL DVLAQAQRPL LVLGKGAAYA QADNVIREFV 241 EHTGIPFLPM SMAKGLLPDS HPQSAAAARS LAMARADVVL LVGARLNWLL GNGESPQWSA 301 DAKFIQVDIE ASEFDSNRPI VAPLTGDIGS VMSALLEAAA DRSSVASAAW TGELADRKAR 361 NSAKMRRRLA DDHHPMRFYN ALGAIRSVLQ RNPDVYVVNE GANALDLARN IIDMHLPRHR 421 LDSGTWGVMG IGMGYAIAAA VETGRPVVAI EGDSAFGFSG MEFETICRYR LPVTVVILNN 481 GGVYRGDEAT IFRSAAPVWR HDPAPTVLNA HARHELIAEA FGGKGYHVST PTELESALTD 541 ALASNGPSLI DCELDPADGV ESGHLAKLNT TSAATPAISG DG //