LOCUS       CAB5247818.1             318 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            GDP-MANNOSE 4,6-DEHYDRATASE GCA (GDP-D-MANNOSE DEHYDRATASE)
            protein.
ACCESSION   LT708304-117
PROTEIN_ID  CAB5247818.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="gca"
                     /locus_tag="BQ2027_MB0116"
                     /note="Mb0116, gca, len: 318 aa. Equivalent to Rv0112,
                     len: 318 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 318 aa overlap). Possible gca,
                     GDP-mannose 4,6-dehydratase (EC 4.2.1.47), similar to
                     others e g. U18320|PAU18320_1 GDP-D-mann from Pseudomonas
                     aeruginosa (323 aa), FASTA scores: opt: 415, E(): 4.4e-21,
                     (27.0% identity in 318 aa overlap). Similar to Rv3634c,
                     Rv3784, etc from Mycobacterium tuberculosis. Contains
                     PS00061 Short-chain dehydrogenases/reductases family
                     signature. SEEMS TO BELONG TO THE GDP-MANNOSE
                     4,6-DEHYDRATASE FAMILY. COFACTOR: NAD(+). Protein product
                     from Mb0116 detected using SWATH mass spectrometry. Mb0116
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
BEGIN
        1 MKVWITGAGG MMGSHLAEML LAAGHDVYAT YCRPTIDPSD LQFNGAEVDI TDWCSVYDSI
       61 ATFRPDAVFH LAAQSYPAVS WARPVETLTT NMVGTAIVFE ALRRVRPHAK IIVAGSSAEY
      121 GFVDPSEVPI NERRELRPLH PYGVSKAATD MLAYQYHKSY GMHTVVARIF NCTGPRKVGD
      181 ALSDFVRRCT WLEHHPEQSA IRVGNLKTKR TIVDVRDLNR ALMLMLDKGE AGADYNVGGS
      241 IAYEMGDVLK QVIAACKRDD IVPEVDPALL RPTDEKIIYG DCSKLAAITG WQQEICLTQT
      301 IADMFDYWRS KSESALMV
//