LOCUS CAB5247809.1 752 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE CATION-TRANSPORTER P-TYPE ATPASE B CTPB protein. ACCESSION LT708304-108 PROTEIN_ID CAB5247809.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="ctpB" /locus_tag="BQ2027_MB0106C" /note="Mb0106c, ctpB, len: 752 aa. Equivalent to Rv0103c, len: 752 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 752 aa overlap). Probable ctpB, cation-transporting P-type ATPase B (transmembrane protein) (EC 3.6.3.-), equivalent to CTPB_MYCLE|P46840 cation-transporting P-type ATPase B from Mycobacterium leprae (750 aa), FASTA scores: opt: 3615, E(): 0, (76.5% identity in 752 aa overlap). Also highly similar to others e.g. CAB96031.1|AL360055 putative metal transporter ATPase from Streptomyces coelicolor (753 aa); NP_241423.1|NC_002570 copper-transporting ATPase from Bacillus halodurans (806 aa); etc. Also highly similar to Z46257|MLACEA_7 aceA gene for isocitrate L from Mycobacterium leprae (750 aa), FASTA scores: opt: 3615, E():0, (76.5% identity in 752 aa overlap). And similar to MTCY251.11 from Mycobacterium tuberculosis, FASTA score: (68.3% identity in 742 aa overlap). Contains PS01047 Heavy-metal-associated domain, PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB. Protein product from Mb0106c detected using SWATH mass spectrometry. Mb0106c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." BEGIN 1 MAAPVVGDAD LQSVRRIRLD VSGMSCAACA SRVETKLNKI PGVRASVNFA TRVATIDAVG 61 MAADELCGVV EKAGYHAAPH TETTVLDKRT KDPDGAHARR LLRRLLVAAV LFVPLADLST 121 LFAIVPSARV PGWGYILTAL AAPVVTWAAW PFHSVALRNA RHRTTSMETL ISVGIVAATA 181 WSLSSVFGDQ PPREGSGIWR AILNSDSIYL EVAAGVTVFV LAGRYFEARA KSKAGSALRA 241 LAELGAKNVA VLLPDGAELV IPASELKKRQ RFVTRPGETI AADGVVVDGS AAIDMSAMTG 301 EAKPVRAYPA ASVVGGTVVM DGRLVIEATA VGADTQFAAM VRLVEQAQTQ KARAQRLADH 361 IAGVFVPVVF VIAGLAGAAW LVSGAGADRA FSVTLGVLVI ACPCALGLAT PTAMMVASGR 421 GAQLGIFIKG YRALETIRSI DTVVFDKTGT LTVGQLAVST VTMAGSGTSE RDREEVLGLA 481 AAVESASEHA MAAAIVAASP DPGPVNGFVA VAGCGVSGEV GGHHVEVGKP SWITRTTPCH 541 DAALVSARLD GESRGETVVF VSVDGVVRAA LTIADTLKDS AAAAVAALRS RGLRTILLTG 601 DNRAAADAVA AQVGIDSAVA DMLPEGKVDV IQRLREEGHT VAMVGDGIND GPALVGADLG 661 LAIGRGTDVA LGAADIILVR DDLNTVPQAL DLARATMRTI RMNMIWAFGY NVAAIPIAAA 721 GLLNPLIAGA AMAFSSFFVV SNSLRLRNFG AQ //