LOCUS       CAB5247809.1             752 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CATION-TRANSPORTER P-TYPE ATPASE B CTPB protein.
ACCESSION   LT708304-108
PROTEIN_ID  CAB5247809.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="ctpB"
                     /locus_tag="BQ2027_MB0106C"
                     /note="Mb0106c, ctpB, len: 752 aa. Equivalent to Rv0103c,
                     len: 752 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.9% identity in 752 aa overlap). Probable ctpB,
                     cation-transporting P-type ATPase B (transmembrane
                     protein) (EC 3.6.3.-), equivalent to CTPB_MYCLE|P46840
                     cation-transporting P-type ATPase B from Mycobacterium
                     leprae (750 aa), FASTA scores: opt: 3615, E(): 0, (76.5%
                     identity in 752 aa overlap). Also highly similar to others
                     e.g. CAB96031.1|AL360055 putative metal transporter ATPase
                     from Streptomyces coelicolor (753 aa);
                     NP_241423.1|NC_002570 copper-transporting ATPase from
                     Bacillus halodurans (806 aa); etc. Also highly similar to
                     Z46257|MLACEA_7 aceA gene for isocitrate L from
                     Mycobacterium leprae (750 aa), FASTA scores: opt: 3615,
                     E():0, (76.5% identity in 752 aa overlap). And similar to
                     MTCY251.11 from Mycobacterium tuberculosis, FASTA score:
                     (68.3% identity in 742 aa overlap). Contains PS01047
                     Heavy-metal-associated domain, PS00154 E1-E2 ATPases
                     phosphorylation site. BELONGS TO THE CATION TRANSPORT
                     ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB. Protein
                     product from Mb0106c detected using SWATH mass
                     spectrometry. Mb0106c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
BEGIN
        1 MAAPVVGDAD LQSVRRIRLD VSGMSCAACA SRVETKLNKI PGVRASVNFA TRVATIDAVG
       61 MAADELCGVV EKAGYHAAPH TETTVLDKRT KDPDGAHARR LLRRLLVAAV LFVPLADLST
      121 LFAIVPSARV PGWGYILTAL AAPVVTWAAW PFHSVALRNA RHRTTSMETL ISVGIVAATA
      181 WSLSSVFGDQ PPREGSGIWR AILNSDSIYL EVAAGVTVFV LAGRYFEARA KSKAGSALRA
      241 LAELGAKNVA VLLPDGAELV IPASELKKRQ RFVTRPGETI AADGVVVDGS AAIDMSAMTG
      301 EAKPVRAYPA ASVVGGTVVM DGRLVIEATA VGADTQFAAM VRLVEQAQTQ KARAQRLADH
      361 IAGVFVPVVF VIAGLAGAAW LVSGAGADRA FSVTLGVLVI ACPCALGLAT PTAMMVASGR
      421 GAQLGIFIKG YRALETIRSI DTVVFDKTGT LTVGQLAVST VTMAGSGTSE RDREEVLGLA
      481 AAVESASEHA MAAAIVAASP DPGPVNGFVA VAGCGVSGEV GGHHVEVGKP SWITRTTPCH
      541 DAALVSARLD GESRGETVVF VSVDGVVRAA LTIADTLKDS AAAAVAALRS RGLRTILLTG
      601 DNRAAADAVA AQVGIDSAVA DMLPEGKVDV IQRLREEGHT VAMVGDGIND GPALVGADLG
      661 LAIGRGTDVA LGAADIILVR DDLNTVPQAL DLARATMRTI RMNMIWAFGY NVAAIPIAAA
      721 GLLNPLIAGA AMAFSSFFVV SNSLRLRNFG AQ
//