LOCUS       CAB5247805.1             540 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            FATTY-ACID-COA LIGASE FADD10 (FATTY-ACID-COA SYNTHETASE)
            (FATTY-ACID-COA SYNTHASE) protein.
ACCESSION   LT708304-104
PROTEIN_ID  CAB5247805.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="fadD10"
                     /locus_tag="BQ2027_MB0102"
                     /note="Mb0102, fadD10, len: 540 aa. Equivalent to Rv0099,
                     len: 540 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 540 aa overlap). Possible fadD10,
                     fatty-acid-CoA synthetase (EC 6.2.1.-), equivalent to
                     MLACEA_4|Q50176 LONG CHAIN FATTY ACID-COA LIGASE from
                     Mycobacterium leprae (532 aa), FASTA scores: opt: 2580,
                     E(): 0, (74.6% identity in 531 aa overlap). Also similar
                     to many e.g. BAB69379.1|AB070955 long-chain fatty
                     acid--CoA ligase from Streptomyces avermitilis (518 aa);
                     NP_419782.1|NC_002696 putativ long-chain-fatty-acid--CoA
                     ligase from Caulobacter crescentus (530 aa);
                     NP_435326.1|NC_003037 probable long chain fatty acid CoA
                     ligase from Sinorhizobium meliloti (508 aa); etc. Also
                     similar to ACSA_BACSU|P39062 acetyl-coenzyme A synthetase
                     from Bacillus subtilis (572 aa), FASTA scores: opt: 415,
                     E(): 9.8e-20, (27.1% identity in 539 aa overlap). Contains
                     PS00455 putative AMP-binding domain signature. BELONGS TO
                     THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. Protein
                     product from Mb0102 detected using SWATH mass
                     spectrometry. Mb0102 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
BEGIN
        1 MGGKKFQAMP QLPSTVLDRV FEQARQQPEA IALRRCDGTS ALRYRELVAE VGGLAADLRA
       61 QSVSRGSRVL VISDNGPETY LSVLACAKLG AIAVMADGNL PIAAIERFCQ ITDPAAALVA
      121 PGSKMASSAV PEALHSIPVI AVDIAAVTRE SEHSLDAASL AGNADQGSED PLAMIFTSGT
      181 TGEPKAVLLA NRTFFAVPDI LQKEGLNWVT WVVGETTYSP LPATHIGGLW WILTCLMHGG
      241 LCVTGGENTT SLLEILTTNA VATTCLVPTL LSKLVSELKS ANATVPSLRL VGYGGSRAIA
      301 ADVRFIEATG VRTAQVYGLS ETGCTALCLP TDDGSIVKIE AGAVGRPYPG VDVYLAATDG
      361 IGPTAPGAGP SASFGTLWIK SPANMLGYWN NPERTAEVLI DGWVNTGDLL ERREDGFFYI
      421 KGRSSEMIIC GGVNIAPDEV DRIAEGVSGV REAACYEIPD EEFGALVGLA VVASAELDES
      481 AARALKHTIA ARFRRESEPM ARPSTIVIVT DIPRTQSGKV MRASLAAAAT ADKARVVVRG
//