LOCUS       CAB5247797.1             255 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            bifunctional mta/sah nucleosidase mtn: 5'-methylthioadenosine
            nucleosidase (methylthioadenosine methylthioribohydrolase)
            + s-adenosylhomocysteine nucleosidase (s-adenosyl-l-homocysteine
            homocysteinylribohydrolase) protein.
ACCESSION   LT708304-96
PROTEIN_ID  CAB5247797.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mtn"
                     /locus_tag="BQ2027_MB0094"
                     /note="Mb0094, mtn, len: 255 aa. Equivalent to Rv0091,
                     len: 255 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 255 aa overlap). Probable mtn
                     (alternate gene name: pfs), MTA/SAH nucleosidase,
                     including 5'-methylthioadenosine nucleosidase (EC
                     3.2.2.16) and S-adenosylhomocysteine nucleosidase (EC
                     3.2.2.9), similar to others e.g. NP_521493.1|NC_003295
                     PROBABLE BIFUNCTIONAL PROTEIN (MTA/SAH NUCLEOSIDASE)
                     (P46): 5'-METHYLTHIOADENOSINE NUCLEOSIDASE AND
                     S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE from Ralstonia
                     solanacearum (261 aa); AAC45731.1|U55214 Pfs from
                     Treponema pallidum (249 aa); P96122|MTN_TREPA MTA/SAH
                     NUCLEOSIDASE from Treponema pallidum (269 aa);
                     PFS_ECOLI|P24247 pfs protein (p46) from Escherichia coli
                     (232 aa), FASTA scores: opt: 214, E(): 3.8e-08, (30.5%
                     identity in 246 aa overlap); etc. BELONGS TO THE MTN
                     FAMILY. Protein product from Mb0094 detected using SWATH
                     mass spectrometry. Mb0094 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
BEGIN
        1 MAVTVGVICA IPQELAYLRG VLVDAKRQQV AQILFDSGQL DAHRVVLAAA GMGKVNTGLT
       61 ATLLADRFGC RTIVFTGVAG GLDPELCIGD IVIADRVVQH DFGLLTDERL RPYQPGHIPF
      121 IEPTERLGYP VDPAVIDRVK HRLDGFTLAP LSTAAGGGGR QPRIYYGTIL TGDQYLHCER
      181 TRNRLHHELG GMAVEMEGGA VAQICASFDI PWLVIRALSD LAGADSGVDF NRFVGEVAAS
      241 SARVLLRLLP VLTAC
//