LOCUS CAB5247795.1 197 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE METHYLTRANSFERASE/METHYLASE protein. ACCESSION LT708304-94 PROTEIN_ID CAB5247795.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB0092" /note="Mb0092, -, len: 197 aa. Equivalent to Rv0089, len: 197 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 197 aa overlap). Possible methyltransferase (EC 2.1.1.-), showing some weak similarity to others e.g. NP_299749.1|NC_002488 3-demethylubiquinone-9 3-methyltransferase from Xylella fastidiosa 9a5c (246 aa); CAC44277.1| (AL596030) putative methyltransferase from Streptomyces coelicolor (285 aa); NP_111415.1|NC_002689 Predicted SAM-dependent methyltransferase from Thermoplasma volcanium (245 aa); etc. Also some similarity with many biotin biosynthesis proteins e.g. P12999|BIOC_ECOLI|B0777 BIOTIN SYNTHESIS PROTEIN from Escherichia coli (251 aa), FASTA scores: opt: 202, E(): 4.5e-07, (39.0% identity in 118 aa overlap); etc. BELONGS TO THE METHYLTRANSFERASE SUPERFAMILY. Mb0092 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." BEGIN 1 MDQPWNANIH YDALLDAMVP LGTQCVLDVG CGDGLLAARL ARRIPYVTAV DIDAPVLRRA 61 QTRFANAPIR WLHADIMTAE LPNAGFDAVV SNAALHHIED TRTALSRLGG LVTPGGTLAV 121 VTFVTPSLRN GLWHLTSWVA CGMANRVKGK WEHSAPIKWP PPQTLHELRS HVRALLPGAC 181 IRRLLYGRVL VTWRAPV //