LOCUS       CAB5247795.1             197 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            METHYLTRANSFERASE/METHYLASE protein.
ACCESSION   LT708304-94
PROTEIN_ID  CAB5247795.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0092"
                     /note="Mb0092, -, len: 197 aa. Equivalent to Rv0089, len:
                     197 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 197 aa overlap). Possible
                     methyltransferase (EC 2.1.1.-), showing some weak
                     similarity to others e.g. NP_299749.1|NC_002488
                     3-demethylubiquinone-9 3-methyltransferase from Xylella
                     fastidiosa 9a5c (246 aa); CAC44277.1| (AL596030) putative
                     methyltransferase from Streptomyces coelicolor (285 aa);
                     NP_111415.1|NC_002689 Predicted SAM-dependent
                     methyltransferase from Thermoplasma volcanium (245 aa);
                     etc. Also some similarity with many biotin biosynthesis
                     proteins e.g. P12999|BIOC_ECOLI|B0777 BIOTIN SYNTHESIS
                     PROTEIN from Escherichia coli (251 aa), FASTA scores: opt:
                     202, E(): 4.5e-07, (39.0% identity in 118 aa overlap);
                     etc. BELONGS TO THE METHYLTRANSFERASE SUPERFAMILY. Mb0092
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
BEGIN
        1 MDQPWNANIH YDALLDAMVP LGTQCVLDVG CGDGLLAARL ARRIPYVTAV DIDAPVLRRA
       61 QTRFANAPIR WLHADIMTAE LPNAGFDAVV SNAALHHIED TRTALSRLGG LVTPGGTLAV
      121 VTFVTPSLRN GLWHLTSWVA CGMANRVKGK WEHSAPIKWP PPQTLHELRS HVRALLPGAC
      181 IRRLLYGRVL VTWRAPV
//