LOCUS       CAB5247776.1             280 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            GLUTAMINE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER
            GLNQ protein.
ACCESSION   LT708304-75
PROTEIN_ID  CAB5247776.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0074"
                     /note="Mb0074, -, len: 280 aa. Equivalent to 5' end of
                     Rv0073, len: 330 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (94.9% identity in 275 aa overlap). Probable
                     glutamine-transport ATP-binding protein ABC-transporter
                     (see citation below), similar to many ATP-binding proteins
                     e.g. NP_070646.1|NC_000917 ABC transporter ATP-binding
                     protein from Archaeoglobus fulgidus (231 aa); T34822
                     ABC-transporter ATP binding protein from Streptomyces
                     coelicolor (230 aa); YBJZ_ECOLI|P75831 hypothetical ABC
                     transporter ATP-binding protein from Escherichia coli (648
                     aa), FASTA scores: opt: 531, E(): 6.8e-30, (38.6% identity
                     in 233 aa overlap); etc. Also highly similar to
                     Y0A4_MYCT|Q50734|MTCY9C4.04c hypothetical ABC transporter
                     ATP-binding protein from Mycobacterium tuberculosis (330
                     aa), FASTA scores: E(): 0, (83.3% identity in 330 aa
                     overlap). Contains PS00017 ATP/GTP-binding site motif A
                     (P-loop), PS00211 ABC transporters family signature, and
                     PS00889 Cyclic nucleotide-binding domain signature 2.
                     BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC
                     TRANSPORTERS). Note that supposed act with near ORF
                     Rv0072|MTV030.16 transmembrane ABC-transporter.
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium
                     tuberculosis strain H37Rv, Rv0073 exists as a single gene.
                     In Mycobacterium bovis, a frameshift due to a single base
                     deletion (a-*) splits Rv0073 into 2 parts, Mb0074 and
                     Mb0075. Mb0074 found to be expressed during exponential
                     growth in Sauton's minimal media by RNA-sequencing (TPM >
                     20)."
BEGIN
        1 MGDLSIQNLV VEYYSGGYAL RPINGLNLDV AAGSLVMLLG PSGCGKTTLL SCLGGILRPK
       61 SGAIKFDEVD ITTLQGAELA NYRRNKVGIV FQAFNLVPSL TAVENVMVPL RSAGMSRRAS
      121 RRRAEELLAR VNLAERMNHR PGDLSGGQQQ RVAVARAIAL DPPLILADEP TAHLDFIQVE
      181 EVLRLIRELA DGERVVVVAT HDSRMLPMAD RVVELTPDFA ETNRPPETVH LQAGEVLFEQ
      241 STMGDLIYVV SEGEFEIVHD WPTAVRNWSR LPGRGITSAR
//