LOCUS CAA69695.1 503 aa PRT HUM 07-OCT-2008 DEFINITION Homo sapiens nicotinic acetylcholine receptor alpha3 subunit precursor protein. ACCESSION Y08418-1 PROTEIN_ID CAA69695.1 SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 AUTHORS Groot Kormelink P.J., Luyten W.H.M.L. TITLE Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32 JOURNAL FEBS Lett. 400(3), 309-314(1997). PUBMED 9009220 REFERENCE 2 (bases 1 to 1512) AUTHORS Groot Kormelink P.J. JOURNAL Submitted (27-SEP-1996) to the INSDC. P.J. Groot Kormelink, Janssen Research Foundation, Exp. Mol. Biol. Dept., Turnhoutseweg 30, B-2340 Beerse, BELGIUM REFERENCE 3 AUTHORS Groot-Kormelink P.J., Luyten W.H.M.L., Colquhoun D., Sivilotti L.G. TITLE A reporter mutation approach shows incorporation of the orphan subunit beta3 into a functional nicotinic receptor JOURNAL J Biol Chem 273(25), 15317-15320(1998). PUBMED 9624109 REFERENCE 4 AUTHORS Boorman J.P., Groot-Kormelink P.J., Sivilotti L.G. TITLE Stoichiometry of human recombinant neuronal nicotinic receptors containing the beta3 subunit expressed in Xenopus oocytes JOURNAL J. Physiol. (Lond.) 529, 565-577(2000). REFERENCE 5 AUTHORS Groot-Kormelink P.J., Boorman J.P., Sivilotti L.G. TITLE Formation of functional alpha3beta4alpha5 human neuronal nicotinic receptors in Xenopus oocytes: a reporter mutation approach JOURNAL Br. J. Pharmacol. 134(4), 789-796(2001). PUBMED 11606319 REFERENCE 6 AUTHORS Boorman J.P., Beato M., Groot-Kormelink P.J., Broadbent S.D., Sivilotti L.G. TITLE The effects of beta3 subunit incorporation on the pharmacology and single channel properties of oocyte-expressed human alpha3beta4 neuronal nicotinic receptors JOURNAL J Biol Chem 278(45), 44033-44040(2003). PUBMED 12912995 FEATURES Qualifiers source /db_xref="H-InvDB:HIT000325449" /organism="Homo sapiens" /mol_type="mRNA" /cell_line="IMR-32" /cell_line="SH-SY5Y" /cell_type="neuroblastoma" /db_xref="taxon:9606" protein /gene="nAChRA3" /db_xref="GOA:P32297" /db_xref="H-InvDB:HIT000325449.12" /db_xref="HGNC:HGNC:1957" /db_xref="InterPro:IPR002394" /db_xref="InterPro:IPR006029" /db_xref="InterPro:IPR006201" /db_xref="InterPro:IPR006202" /db_xref="InterPro:IPR018000" /db_xref="InterPro:IPR036719" /db_xref="InterPro:IPR036734" /db_xref="PDB:4ZK4" /db_xref="PDB:5SYO" /db_xref="PDB:5TVC" /db_xref="UniProtKB/Swiss-Prot:P32297" BEGIN 1 MALAVSLPLA LSPPRLLLLL LSLLPVARAS EAEHRLFERL FEDYNEIIRP VANVSDPVII 61 HFEVSMSQLV KVDEVNQIME TNLWLKQIWN DYKLKWNPSD YGGAEFMRVP AQKIWKPDIV 121 LYNNAVGDFQ VDDKTKALLK YTGEVTWIPP AIFKSSCKID VTYFPFDYQN CTMKFGSWSY 181 DKAKIDLVLI GSSMNLKDYW ESGEWAIIKA PGYKHDIKYN CCEEIYPDIT YSLYIRRLPL 241 FYTINLIIPC LLISFLTVLV FYLPSDCGEK VTLCISVLLS LTVFLLVITE TIPSTSLVIP 301 LIGEYLLFTM IFVTLSIVIT VFVLNVHYRT PTTHTMPSWV KTVFLNLLPR VMFMTRPTSN 361 EGNAQKPRPL YGAELSNLNC FSRAESKGCK EGYPCQDGMC GYCHHRRIKI SNFSANLTRS 421 SSSESVDAVL SLSALSPEIK EAIQSVKYIA ENMKAQNEAK EIQDDWKYVA MVIDRIFLWV 481 FTLVCILGTA GLFLQPLMAR EDA //