LOCUS       CAA69695.1               503 aa    PRT              HUM 07-OCT-2008
DEFINITION  Homo sapiens nicotinic acetylcholine receptor alpha3 subunit
            precursor protein.
ACCESSION   Y08418-1
PROTEIN_ID  CAA69695.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1
  AUTHORS   Groot Kormelink P.J., Luyten W.H.M.L.
  TITLE     Cloning and sequence of full-length cDNAs encoding the human
            neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3
            and beta4 and expression of seven nAChR subunits in the human
            neuroblastoma cell line SH-SY5Y and/or IMR-32
  JOURNAL   FEBS Lett. 400(3), 309-314(1997).
   PUBMED   9009220
REFERENCE   2  (bases 1 to 1512)
  AUTHORS   Groot Kormelink P.J.
  JOURNAL   Submitted (27-SEP-1996) to the INSDC. P.J. Groot Kormelink, Janssen
            Research Foundation, Exp. Mol. Biol. Dept., Turnhoutseweg 30,
            B-2340 Beerse, BELGIUM
REFERENCE   3
  AUTHORS   Groot-Kormelink P.J., Luyten W.H.M.L., Colquhoun D., Sivilotti L.G.
  TITLE     A reporter mutation approach shows incorporation of the orphan
            subunit beta3 into a functional nicotinic receptor
  JOURNAL   J Biol Chem 273(25), 15317-15320(1998).
   PUBMED   9624109
REFERENCE   4
  AUTHORS   Boorman J.P., Groot-Kormelink P.J., Sivilotti L.G.
  TITLE     Stoichiometry of human recombinant neuronal nicotinic receptors
            containing the beta3 subunit expressed in Xenopus oocytes
  JOURNAL   J. Physiol. (Lond.) 529, 565-577(2000).
REFERENCE   5
  AUTHORS   Groot-Kormelink P.J., Boorman J.P., Sivilotti L.G.
  TITLE     Formation of functional alpha3beta4alpha5 human neuronal nicotinic
            receptors in Xenopus oocytes: a reporter mutation approach
  JOURNAL   Br. J. Pharmacol. 134(4), 789-796(2001).
   PUBMED   11606319
REFERENCE   6
  AUTHORS   Boorman J.P., Beato M., Groot-Kormelink P.J., Broadbent S.D.,
            Sivilotti L.G.
  TITLE     The effects of beta3 subunit incorporation on the pharmacology and
            single channel properties of oocyte-expressed human alpha3beta4
            neuronal nicotinic receptors
  JOURNAL   J Biol Chem 278(45), 44033-44040(2003).
   PUBMED   12912995
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000325449"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /cell_line="IMR-32"
                     /cell_line="SH-SY5Y"
                     /cell_type="neuroblastoma"
                     /db_xref="taxon:9606"
     protein         /gene="nAChRA3"
                     /db_xref="GOA:P32297"
                     /db_xref="H-InvDB:HIT000325449.12"
                     /db_xref="HGNC:HGNC:1957"
                     /db_xref="InterPro:IPR002394"
                     /db_xref="InterPro:IPR006029"
                     /db_xref="InterPro:IPR006201"
                     /db_xref="InterPro:IPR006202"
                     /db_xref="InterPro:IPR018000"
                     /db_xref="InterPro:IPR036719"
                     /db_xref="InterPro:IPR036734"
                     /db_xref="PDB:4ZK4"
                     /db_xref="PDB:5SYO"
                     /db_xref="PDB:5TVC"
                     /db_xref="UniProtKB/Swiss-Prot:P32297"
BEGIN
        1 MALAVSLPLA LSPPRLLLLL LSLLPVARAS EAEHRLFERL FEDYNEIIRP VANVSDPVII
       61 HFEVSMSQLV KVDEVNQIME TNLWLKQIWN DYKLKWNPSD YGGAEFMRVP AQKIWKPDIV
      121 LYNNAVGDFQ VDDKTKALLK YTGEVTWIPP AIFKSSCKID VTYFPFDYQN CTMKFGSWSY
      181 DKAKIDLVLI GSSMNLKDYW ESGEWAIIKA PGYKHDIKYN CCEEIYPDIT YSLYIRRLPL
      241 FYTINLIIPC LLISFLTVLV FYLPSDCGEK VTLCISVLLS LTVFLLVITE TIPSTSLVIP
      301 LIGEYLLFTM IFVTLSIVIT VFVLNVHYRT PTTHTMPSWV KTVFLNLLPR VMFMTRPTSN
      361 EGNAQKPRPL YGAELSNLNC FSRAESKGCK EGYPCQDGMC GYCHHRRIKI SNFSANLTRS
      421 SSSESVDAVL SLSALSPEIK EAIQSVKYIA ENMKAQNEAK EIQDDWKYVA MVIDRIFLWV
      481 FTLVCILGTA GLFLQPLMAR EDA
//