LOCUS CAA69693.1 498 aa PRT HUM 21-OCT-2008 DEFINITION Homo sapiens nicotinic acetylcholine receptor beta4 subunit precursor protein. ACCESSION Y08416-1 PROTEIN_ID CAA69693.1 SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 AUTHORS Groot Kormelink P.J., Luyten W.H.M.L. TITLE Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32 JOURNAL FEBS Lett. 400(3), 309-314(1997). PUBMED 9009220 REFERENCE 2 (bases 1 to 1588) AUTHORS Groot Kormelink P.J. JOURNAL Submitted (27-SEP-1996) to the INSDC. P.J. Groot Kormelink, Janssen Research Foundation, Exp. Mol. Biol. Dept., Turnhoutseweg 30, B-2340 Beerse, BELGIUM REFERENCE 3 AUTHORS Boorman J.P., Groot-Kormelink P.J., Sivilotti L.G. TITLE Stoichiometry of human recombinant neuronal nicotinic receptors containing the beta3 subunit expressed in Xenopus oocytes JOURNAL J. Physiol. (Lond.) 529, 565-577(2000). REFERENCE 4 AUTHORS Groot-Kormelink P.J., Boorman J.P., Sivilotti L.G. TITLE Formation of functional alpha3beta4alpha5 human neuronal nicotinic receptors in Xenopus oocytes: a reporter mutation approach JOURNAL Br. J. Pharmacol. 134(4), 789-796(2001). PUBMED 11606319 REFERENCE 5 AUTHORS Boorman J.P., Beato M., Groot-Kormelink P.J., Broadbent S.D., Sivilotti L.G. TITLE The effects of beta3 subunit incorporation on the pharmacology and single channel properties of oocyte-expressed human alpha3beta4 neuronal nicotinic receptors JOURNAL J Biol Chem 278(45), 44033-44040(2003). PUBMED 12912995 FEATURES Qualifiers source /db_xref="H-InvDB:HIT000325447" /organism="Homo sapiens" /mol_type="mRNA" /cell_line="SH-SY5Y" /cell_line="IMR-32" /cell_type="neuroblastoma" /db_xref="taxon:9606" protein /gene="nAChRB4" /db_xref="GOA:P30926" /db_xref="H-InvDB:HIT000325447.12" /db_xref="HGNC:HGNC:1964" /db_xref="InterPro:IPR002394" /db_xref="InterPro:IPR006029" /db_xref="InterPro:IPR006201" /db_xref="InterPro:IPR006202" /db_xref="InterPro:IPR018000" /db_xref="InterPro:IPR036719" /db_xref="InterPro:IPR036734" /db_xref="PDB:2ASG" /db_xref="UniProtKB/Swiss-Prot:P30926" BEGIN 1 MRRAPSLVLF FLVALCGRGN CRVANAEEKL MDDLLNKTRY NNLIRPATSS SQLISIKLQL 61 SLAQLISVNE REQIMTTNVW LKQEWTDYRL TWNSSRYEGV NILRIPAKRI WLPDIVLYNN 121 ADGTYEVSVY TNLIVRSNGS VLWLPPAIYK SACKIEVKYF PFDQQNCTLK FRSWTYDHTE 181 IDMVLMTPTA SMDDFTPSGE WDIVALPGRR TVNPQDPSYV DVTYDFIIKR KPLFYTINLI 241 IPCVLTTLLA ILVFYLPSDC GEKMTLCISV LLALTFFLLL ISKIVPPTSL DVPLIGKYLM 301 FTMVLVTFSI VTSVCVLNVH HRSPSTHTMA PWVKRCFLHK LPTFLFMKRP GPDSSPARAF 361 PPSKSCVTKP EATATSTSPS NFYGNSMYFV NPASAASKSP AGSTPVAIPR DFWLRSSGRF 421 RQDVQEALEG VSFIAQHMKN DDEDQSVVED WKYVAMVVDR LFLWVFMFVC VLGTVGLFLP 481 PLFQTHAASE GPYAAQRD //