LOCUS       CAA69693.1               498 aa    PRT              HUM 21-OCT-2008
DEFINITION  Homo sapiens nicotinic acetylcholine receptor beta4 subunit
            precursor protein.
ACCESSION   Y08416-1
PROTEIN_ID  CAA69693.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1
  AUTHORS   Groot Kormelink P.J., Luyten W.H.M.L.
  TITLE     Cloning and sequence of full-length cDNAs encoding the human
            neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3
            and beta4 and expression of seven nAChR subunits in the human
            neuroblastoma cell line SH-SY5Y and/or IMR-32
  JOURNAL   FEBS Lett. 400(3), 309-314(1997).
   PUBMED   9009220
REFERENCE   2  (bases 1 to 1588)
  AUTHORS   Groot Kormelink P.J.
  JOURNAL   Submitted (27-SEP-1996) to the INSDC. P.J. Groot Kormelink, Janssen
            Research Foundation, Exp. Mol. Biol. Dept., Turnhoutseweg 30,
            B-2340 Beerse, BELGIUM
REFERENCE   3
  AUTHORS   Boorman J.P., Groot-Kormelink P.J., Sivilotti L.G.
  TITLE     Stoichiometry of human recombinant neuronal nicotinic receptors
            containing the beta3 subunit expressed in Xenopus oocytes
  JOURNAL   J. Physiol. (Lond.) 529, 565-577(2000).
REFERENCE   4
  AUTHORS   Groot-Kormelink P.J., Boorman J.P., Sivilotti L.G.
  TITLE     Formation of functional alpha3beta4alpha5 human neuronal nicotinic
            receptors in Xenopus oocytes: a reporter mutation approach
  JOURNAL   Br. J. Pharmacol. 134(4), 789-796(2001).
   PUBMED   11606319
REFERENCE   5
  AUTHORS   Boorman J.P., Beato M., Groot-Kormelink P.J., Broadbent S.D.,
            Sivilotti L.G.
  TITLE     The effects of beta3 subunit incorporation on the pharmacology and
            single channel properties of oocyte-expressed human alpha3beta4
            neuronal nicotinic receptors
  JOURNAL   J Biol Chem 278(45), 44033-44040(2003).
   PUBMED   12912995
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000325447"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /cell_line="SH-SY5Y"
                     /cell_line="IMR-32"
                     /cell_type="neuroblastoma"
                     /db_xref="taxon:9606"
     protein         /gene="nAChRB4"
                     /db_xref="GOA:P30926"
                     /db_xref="H-InvDB:HIT000325447.12"
                     /db_xref="HGNC:HGNC:1964"
                     /db_xref="InterPro:IPR002394"
                     /db_xref="InterPro:IPR006029"
                     /db_xref="InterPro:IPR006201"
                     /db_xref="InterPro:IPR006202"
                     /db_xref="InterPro:IPR018000"
                     /db_xref="InterPro:IPR036719"
                     /db_xref="InterPro:IPR036734"
                     /db_xref="PDB:2ASG"
                     /db_xref="UniProtKB/Swiss-Prot:P30926"
BEGIN
        1 MRRAPSLVLF FLVALCGRGN CRVANAEEKL MDDLLNKTRY NNLIRPATSS SQLISIKLQL
       61 SLAQLISVNE REQIMTTNVW LKQEWTDYRL TWNSSRYEGV NILRIPAKRI WLPDIVLYNN
      121 ADGTYEVSVY TNLIVRSNGS VLWLPPAIYK SACKIEVKYF PFDQQNCTLK FRSWTYDHTE
      181 IDMVLMTPTA SMDDFTPSGE WDIVALPGRR TVNPQDPSYV DVTYDFIIKR KPLFYTINLI
      241 IPCVLTTLLA ILVFYLPSDC GEKMTLCISV LLALTFFLLL ISKIVPPTSL DVPLIGKYLM
      301 FTMVLVTFSI VTSVCVLNVH HRSPSTHTMA PWVKRCFLHK LPTFLFMKRP GPDSSPARAF
      361 PPSKSCVTKP EATATSTSPS NFYGNSMYFV NPASAASKSP AGSTPVAIPR DFWLRSSGRF
      421 RQDVQEALEG VSFIAQHMKN DDEDQSVVED WKYVAMVVDR LFLWVFMFVC VLGTVGLFLP
      481 PLFQTHAASE GPYAAQRD
//