LOCUS CAA65763.1 121 aa PRT HUM 14-NOV-2006 DEFINITION Homo sapiens immunoglobulin heavy chain protein. ACCESSION X97051-1 PROTEIN_ID CAA65763.1 SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 92588) AUTHORS Corbett S. JOURNAL Submitted (02-APR-1996) to the INSDC. S. Corbett, MRC, Centre for Protein Eng., Hills Road, Cambridge, CB2 2QH, UK REFERENCE 2 (bases 1 to 92588) AUTHORS Buluwela L., Albertson D.G., Sherrington P., Rabbitts P.H., Spurr N., Rabbitts T.H. TITLE The use of chromosomal translocations to study human immunoglobulin gene organization: mapping DH segments within 35 kb of the C mu gene and identification of a new DH locus JOURNAL EMBO J. 7(7), 2003-2010(1988). PUBMED 3138112 REFERENCE 3 (bases 38035 to 52980) AUTHORS Ichihara Y., Matsuoka H., Kurosawa Y. TITLE Organization of human immunoglobulin heavy chain diversity gene loci JOURNAL EMBO J. 7(13), 4141-4150(1988). PUBMED 3243276 REFERENCE 4 (bases 87277 to 89821) AUTHORS Mattila P.S., Shugk J., Hongyan W., Makela O. TITLE Extensive allelic sequence variation in the J region of the human immunoglobulin heavy chain gene locus JOURNAL Eur. J. Immunol. 25(9), 2578-2582(1995). PUBMED 7589129 REFERENCE 5 (bases 86830 to 89967) AUTHORS Ravetch J.V., Siebenlist U., Korsmeyer S., Waldmann T., Leder P. TITLE Structure of the human immunoglobulin mu locus: characterization of embryonic and rearranged J and D genes JOURNAL Cell 27(3 Pt 2), 583-591(1981). PUBMED 6101209 REFERENCE 6 (bases 90650 to 91231) AUTHORS Rabbitts T.H., Forster A., Baer R., Hamlyn P.H. TITLE Transcription enhancer identified near the human C mu immunoglobulin heavy chain gene is unavailable to the translocated c-myc gene in a Burkitt lymphoma JOURNAL Nature 306(5945), 806-809(1983). PUBMED 6419124 REFERENCE 7 (bases 36339 to 36426) AUTHORS Siebenlist U., Ravetch J.V., Korsmeyer S., Waldmann T., Leder P. TITLE Human immunoglobulin D segments encoded in tandem multigenic families JOURNAL Nature 294(5842), 631-635(1981). PUBMED 7312051 REFERENCE 8 (bases 12996 to 13531) AUTHORS Buluwela L., Rabitts T.H. TITLE A VH gene is located within 95 Kb of the human immunoglobulin heavy chain constant region genes JOURNAL Eur. J. Immunol. 18(11), 1843-1845(1988). PUBMED 3144456 REFERENCE 9 (bases 45954 to 46041) AUTHORS Siebenlist U., Ravetch J.V., Korsmeyer S., Waldmann T., Leder P. TITLE Human immunoglobulin D segments encoded in tandem multigenic families JOURNAL Nature 294(5842), 631-635(1981). PUBMED 7312051 REFERENCE 10 (bases 55207 to 55294) AUTHORS Siebenlist U., Ravetch J.V., Korsmeyer S., Waldmann T., Leder P. TITLE Human immunoglobulin D segments encoded in tandem multigenic families JOURNAL Nature 294(5842), 631-635(1981). PUBMED 7312051 REFERENCE 11 (bases 64614 to 64700) AUTHORS Siebenlist U., Ravetch J.V., Korsmeyer S., Waldmann T., Leder P. TITLE Human immunoglobulin D segments encoded in tandem multigenic families JOURNAL Nature 294(5842), 631-635(1981). PUBMED 7312051 COMMENT This sequence of the human immunoglobulin D segment locus was determined from three overlapping cosmids; COS23, COS21 and COS24 (described in reference [2] above). All the sequencing and analysis was carried out at the Sanger Centre (Hinxton, Cambs, CB10 1RQ, England) whose financial and technical assistance is gratefully acknowledged. FEATURES Qualifiers source /organism="Homo sapiens" /chromosome="14" /map="14q32.33" /mol_type="genomic DNA" /germline /db_xref="taxon:9606" protein /gene="IGH@" /citation=[8] intron_pos 17:1 (1/1) BEGIN 1 MSVSFLIFLP VLGLPWGVLS QVQLQQSGPG LVKPSQTLSL TCAISGDSVS SNSAAWNWIR 61 QSPSRGLEWL GRTYYRSKWY NDYAVSVKSR ITINPDTSKN QFSLQLNSVT PEDTAVYYCA 121 R //