LOCUS       CAA65763.1               121 aa    PRT              HUM 14-NOV-2006
DEFINITION  Homo sapiens immunoglobulin heavy chain protein.
ACCESSION   X97051-1
PROTEIN_ID  CAA65763.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 92588)
  AUTHORS   Corbett S.
  JOURNAL   Submitted (02-APR-1996) to the INSDC. S. Corbett, MRC, Centre for
            Protein Eng., Hills Road, Cambridge, CB2 2QH, UK
REFERENCE   2  (bases 1 to 92588)
  AUTHORS   Buluwela L., Albertson D.G., Sherrington P., Rabbitts P.H.,
            Spurr N., Rabbitts T.H.
  TITLE     The use of chromosomal translocations to study human immunoglobulin
            gene organization: mapping DH segments within 35 kb of the C mu
            gene and identification of a new DH locus
  JOURNAL   EMBO J. 7(7), 2003-2010(1988).
   PUBMED   3138112
REFERENCE   3  (bases 38035 to 52980)
  AUTHORS   Ichihara Y., Matsuoka H., Kurosawa Y.
  TITLE     Organization of human immunoglobulin heavy chain diversity gene
            loci
  JOURNAL   EMBO J. 7(13), 4141-4150(1988).
   PUBMED   3243276
REFERENCE   4  (bases 87277 to 89821)
  AUTHORS   Mattila P.S., Shugk J., Hongyan W., Makela O.
  TITLE     Extensive allelic sequence variation in the J region of the human
            immunoglobulin heavy chain gene locus
  JOURNAL   Eur. J. Immunol. 25(9), 2578-2582(1995).
   PUBMED   7589129
REFERENCE   5  (bases 86830 to 89967)
  AUTHORS   Ravetch J.V., Siebenlist U., Korsmeyer S., Waldmann T., Leder P.
  TITLE     Structure of the human immunoglobulin mu locus: characterization of
            embryonic and rearranged J and D genes
  JOURNAL   Cell 27(3 Pt 2), 583-591(1981).
   PUBMED   6101209
REFERENCE   6  (bases 90650 to 91231)
  AUTHORS   Rabbitts T.H., Forster A., Baer R., Hamlyn P.H.
  TITLE     Transcription enhancer identified near the human C mu
            immunoglobulin heavy chain gene is unavailable to the translocated
            c-myc gene in a Burkitt lymphoma
  JOURNAL   Nature 306(5945), 806-809(1983).
   PUBMED   6419124
REFERENCE   7  (bases 36339 to 36426)
  AUTHORS   Siebenlist U., Ravetch J.V., Korsmeyer S., Waldmann T., Leder P.
  TITLE     Human immunoglobulin D segments encoded in tandem multigenic
            families
  JOURNAL   Nature 294(5842), 631-635(1981).
   PUBMED   7312051
REFERENCE   8  (bases 12996 to 13531)
  AUTHORS   Buluwela L., Rabitts T.H.
  TITLE     A VH gene is located within 95 Kb of the human immunoglobulin heavy
            chain constant region genes
  JOURNAL   Eur. J. Immunol. 18(11), 1843-1845(1988).
   PUBMED   3144456
REFERENCE   9  (bases 45954 to 46041)
  AUTHORS   Siebenlist U., Ravetch J.V., Korsmeyer S., Waldmann T., Leder P.
  TITLE     Human immunoglobulin D segments encoded in tandem multigenic
            families
  JOURNAL   Nature 294(5842), 631-635(1981).
   PUBMED   7312051
REFERENCE   10  (bases 55207 to 55294)
  AUTHORS   Siebenlist U., Ravetch J.V., Korsmeyer S., Waldmann T., Leder P.
  TITLE     Human immunoglobulin D segments encoded in tandem multigenic
            families
  JOURNAL   Nature 294(5842), 631-635(1981).
   PUBMED   7312051
REFERENCE   11  (bases 64614 to 64700)
  AUTHORS   Siebenlist U., Ravetch J.V., Korsmeyer S., Waldmann T., Leder P.
  TITLE     Human immunoglobulin D segments encoded in tandem multigenic
            families
  JOURNAL   Nature 294(5842), 631-635(1981).
   PUBMED   7312051
COMMENT     This sequence of the human immunoglobulin D segment locus was
            determined from three overlapping cosmids; COS23, COS21 and COS24
            (described in reference [2] above). All the sequencing and
            analysis was carried out at the Sanger Centre (Hinxton, Cambs,
            CB10 1RQ, England) whose financial and technical assistance is
            gratefully acknowledged.
FEATURES             Qualifiers
     source          /organism="Homo sapiens"
                     /chromosome="14"
                     /map="14q32.33"
                     /mol_type="genomic DNA"
                     /germline
                     /db_xref="taxon:9606"
     protein         /gene="IGH@"
                     /citation=[8]
     intron_pos      17:1 (1/1)
BEGIN
        1 MSVSFLIFLP VLGLPWGVLS QVQLQQSGPG LVKPSQTLSL TCAISGDSVS SNSAAWNWIR
       61 QSPSRGLEWL GRTYYRSKWY NDYAVSVKSR ITINPDTSKN QFSLQLNSVT PEDTAVYYCA
      121 R
//