LOCUS       CAA58411.1              2077 aa    PRT              VRL 08-FEB-2018
DEFINITION  Human betaherpesvirus 6A large tegument protein protein.
ACCESSION   X83413-28
PROTEIN_ID  CAA58411.1
SOURCE      Human betaherpesvirus 6A
  ORGANISM  Human betaherpesvirus 6A
            Viruses; Herpesvirales; Herpesviridae; Betaherpesvirinae;
            Roseolovirus.
REFERENCE   1  (bases 1 to 159378)
  AUTHORS   Gompels U.A., Nicholas J., Lawrence G., Jones M., Thomson B.J.,
            Martin M.E., Efstathiou S., Craxton M., Macaulay H.A.
  TITLE     The DNA sequence of human herpesvirus-6: structure, coding content,
            and genome evolution
  JOURNAL   Virology 209(1), 29-51(1995).
   PUBMED   7747482
REFERENCE   2
  AUTHORS   Lawrence G.L., Chee M., Craxton M.A., Gompels U.A., Honess R.W.,
            Barrell B.G.
  TITLE     Human herpesvirus 6 is closely related to human cytomegalovirus
  JOURNAL   J. Virol. 64(1), 287-299(1990).
   PUBMED   2152817
REFERENCE   3
  AUTHORS   Chang C.K., Balachandran N.
  TITLE     Identification, characterization, and sequence analysis of a cDNA
            encoding a phosphoprotein of human herpesvirus 6
  JOURNAL   J. Virol. 65(6), 2884-2894(1991).
   PUBMED   1851860
REFERENCE   4
  AUTHORS   Teo I.A., Griffin B.E., Jones M.D.
  TITLE     Characterization of the DNA polymerase gene of human herpesvirus 6
  JOURNAL   J. Virol. 65(9), 4670-4680(1991).
   PUBMED   1651403
REFERENCE   5
  AUTHORS   Thomson B.J., Efstathiou S., Honess R.W.
  TITLE     Acquisition of the human adeno-associated virus type-2 rep gene by
            human herpesvirus type-6
  JOURNAL   Nature 351(6321), 78-80(1991).
   PUBMED   1851252
REFERENCE   6
  AUTHORS   Martin M.E.D., Nicholas J., Thomson B.J., Newman C., Honess R.W.
  TITLE     Identification of a transactivating function mapping to the
            putative immediate-early locus of human herpesvirus 6
  JOURNAL   J. Virol. 65(10), 5381-5390(1991).
   PUBMED   1654446
REFERENCE   7
  AUTHORS   Efstathiou S., Lawrence G.L., Brown C.M., Barrell B.G.
  TITLE     Identification of homologs to the human cytomegalovirus US22 gene
            family in human helpesvirus-6
  JOURNAL   J. Gen. Virol. 73, 1661-1671(1992).
   PUBMED   1321206
REFERENCE   8
  AUTHORS   Geng Y., Chandran B., Josephs S.F., Wood C.
  TITLE     Identification and characterization of a human herpesvirus 6 gene
            segment that trans activates the human immunodeficiency virus type
            1 promoter
  JOURNAL   J. Virol. 66(3), 1564-1570(1992).
   PUBMED   1310766
REFERENCE   9
  AUTHORS   Gompels U.A., Carss A.L., Sun N., Arrand J.R.
  TITLE     Infectivity determinants encoded in a conserved gene block of human
            herpesvirus-6
  JOURNAL   DNA Seq 3(1), 25-39(1992).
   PUBMED   1333836
REFERENCE   10
  AUTHORS   Neipel F., Ellinger K., Fleckenstein B.
  TITLE     Gene for the major antigenic structural protein (p100) of human
            herpesvirus 6
  JOURNAL   J. Virol. 66(6), 3918-3924(1992).
   PUBMED   1374813
REFERENCE   11
  AUTHORS   Thomson B.J., Honess R.W.
  TITLE     The right end of the unique region of the genome of human
            herpesvirus 6 U1102 contains a candidate immediate early gene
            enhancer and a homologue of the human cytomegalovirus US22 gene
            family
  JOURNAL   J. Gen. Virol. 73, 1649-1660(1992).
   PUBMED   1321205
REFERENCE   12
  AUTHORS   Ellinger K., Neipel F., Foa-Tomasi L., Campadelli-Fiume G.,
            Fleckenstein B.
  TITLE     The glycoprotein B homologue of human herpesvirus 6
  JOURNAL   J. Gen. Virol. 74, 495-500(1993).
   PUBMED   8383182
REFERENCE   13
  AUTHORS   Gompels U.A., Carrigan D.R., Carss A.L., Arno J.
  TITLE     Two groups of human herpesvirus 6 identified by sequence analyses
            of laboratory strains and variants from Hodgkin's lymphoma and bone
            marrow transplant patients
  JOURNAL   J. Gen. Virol. 74, 613-622(1993).
   PUBMED   8385692
REFERENCE   14
  AUTHORS   Liu D.X., Gompels U.A., Nicholas J., Lelliott C.
  TITLE     Identification and expression of the human herpesvirus 6
            glycoprotein H and interaction with an accessory 40K glycoprotein
  JOURNAL   J. Gen. Virol. 74, 1847-1857(1993).
   PUBMED   8397282
REFERENCE   15
  AUTHORS   Liu D.X., Gompels U.A., Foa-Tomasi L., Campadelli-Fiume G.
  TITLE     Human herpesvirus-6 glycoprotein H and L homologs are components of
            the gp100 complex and the gH external domain is the target for
            neutralizing monoclonal antibodies
  JOURNAL   Virology 197(1), 12-22(1993).
   PUBMED   7692666
REFERENCE   16
  AUTHORS   Pellett P.E., Sanchez-Martinez D., Dominguez G., Black J.B.,
            Anton E., Greenamoyer C., Dambaugh T.R.
  TITLE     A strongly immunoreactive virion protein of human herpesvirus 6
            variant B strain Z29: identification and characterization of the
            gene and mapping of a variant-specific monoclonal antibody reactive
            epitope
  JOURNAL   Virology 195(2), 521-531(1993).
   PUBMED   7687803
REFERENCE   17
  AUTHORS   Pfeiffer B., Berneman Z.N., Neipel F., Chang C.K., Tirwatnapong S.,
            Chandran B.
  TITLE     Identification and mapping of the gene encoding the glycoprotein
            complex gp82-gp105 of human herpesvirus 6 and mapping of the
            neutralizing epitope recognized by monoclonal antibodies
  JOURNAL   J. Virol. 67(8), 4611-4620(1993).
   PUBMED   7687301
REFERENCE   18
  AUTHORS   Gompels U.A., Macaulay H.A.
  TITLE     Characterisation of human telomeric repeat sequences from human
            herpesvirus-6 and relationship to replication
  JOURNAL   J. Gen. Virol. 76, 451-458(1995).
   PUBMED   7844567
REFERENCE   19
  AUTHORS   Dewhurst S., Dollard S.C., Pellett P.E., Dambaugh T.R.
  TITLE     Identification of a lytic-phase origin of DNA replication in human
            herpesvirus 6B strain Z29
  JOURNAL   J. Virol. 67(12), 7680-7683(1993).
   PUBMED   8230490
REFERENCE   20
  AUTHORS   Nicholas J.
  TITLE     Nucleotide sequence of a 21-kilobase-pair region of the genome of
            human herpesvirus-6 containing homologues of human cytomegalovirus
            major immediate-early and replication genes
  JOURNAL   Unpublished.
REFERENCE   21
  AUTHORS   Nicholas J., Martin M.
  TITLE     Nucleotide sequence analysis of a 38.5-kilobase-pair region of the
            genome of human herpesvirus 6 encoding human cytomegalovirus
            immediate-early gene homologs and transactivating functions
  JOURNAL   J. Virol. 68(2), 597-610(1994).
   PUBMED   8289364
REFERENCE   22
  AUTHORS   Schiewe U., Neipel F., Schreiner D., Fleckenstein B.
  TITLE     Structure and transcription of an immediate-early region in the
            human herpesvirus 6 genome
  JOURNAL   J. Virol. 68(5), 2978-2985(1994).
   PUBMED   8151768
REFERENCE   23
  AUTHORS   Thompson J., Choudhury S., Kashanchi F., Doniger J., Berneman Z.,
            Frenkel N., Rosenthal L.J.
  TITLE     A transforming fragment within the direct repeat region of human
            herpesvirus type 6 that transactivates HIV-1
  JOURNAL   Oncogene 9(4), 1167-1175(1994).
   PUBMED   8134119
REFERENCE   24
  AUTHORS   Zhou Y., Chang C.K., Qian G., Chandran B., Wood C.
  TITLE     trans-activation of the HIV promoter by a cDNA and its genomic
            clones of human herpesvirus-6
  JOURNAL   Virology 199(2), 311-322(1994).
   PUBMED   8122364
REFERENCE   25
  AUTHORS   Thomson B.J., Dewhurst S., Gray D.
  TITLE     Structure and heterogeneity of the a sequences of human herpesvirus
            6 strain variants U1102 and Z29 and identification of human
            telomeric repeat sequences at the genomic termini
  JOURNAL   J. Virol. 68(5), 3007-3014(1994).
   PUBMED   8151770
REFERENCE   26
  AUTHORS   Thomson B.J., Weindler F.W., Gray D., Schwaab V., Helbronn R.
  TITLE     Human herpesvirus 6 (HHV-6) is a helper virus for adeno-associated
            virus type 2 (AAV-2) and the AAV-2 rep gene homologue in HHV-6 can
            mediate AAV-2 DNA replication and regulate gene expression
  JOURNAL   Virology 204(1), 304-311(1994).
   PUBMED   8091661
REFERENCE   27
  AUTHORS   Inoue N., Dambaugh T.R., Rapp J.C., Pellett P.E.
  TITLE     Alphaherpesvirus origin-binding protein homolog encoded by human
            herpesvirus 6B, a betaherpesvirus, binds to nucleotide sequences
            that are similar to ori regions of alphaherpesviruses
  JOURNAL   J. Virol. 68(7), 4126-4136(1994).
   PUBMED   8207791
REFERENCE   28
  AUTHORS   Lawrence G.L., Nicholas J., Barrell B.G.
  TITLE     Human herpesvirus 6 (strain U1102) encodes homologues of the
            conserved herpesvirus glycoprotein gM and the alphaherpesvirus
            origin-binding protein
  JOURNAL   J. Gen. Virol. 0, 0(1994).
REFERENCE   29
  AUTHORS   Qian G., Wood C., Chandran B.
  TITLE     Identification and characterization of glycoprotein gH of human
            herpesvirus-6
  JOURNAL   J. Virol. 194, 380-386(1993).
REFERENCE   30
  AUTHORS   Jones M., Teo I.
  TITLE     Identification and analysis of the transport/capsid assembly
            protein (tp/cap) gene of human herpesvirus-6 (HHV6)
  JOURNAL   Virology 197(1), 449-454(1993).
   PUBMED   8212582
REFERENCE   31
  AUTHORS   Littler E., Lawrence G., Liu M.Y., Barrell B.G., Arrand J.R.
  TITLE     Identification, cloning, and expression of the major capsid protein
            gene of human herpesvirus 6
  JOURNAL   J. Virol. 64(2), 714-722(1990).
   PUBMED   2153237
REFERENCE   32
  AUTHORS   Martin M., Thomson B.J., Honess R.W., Craxton M.A., Gompels U.A.,
            Liu M.Y., Littler E., Arrand J.R., Teo I., Jones M.D.
  TITLE     The genome of human herpesvirus 6: Maps of unit-length and
            concatemeric genomes for nine restriction endonucleases
  JOURNAL   J. Gen. Virol. 72, 157-168(1991).
   PUBMED   1846644
REFERENCE   33
  AUTHORS   Chee M.S., Lawrence G.L., Barrell B.G.
  TITLE     Alpha-, beta- and gammaherpesviruses encode a putative
            phosphotransferase
  JOURNAL   J. Gen. Virol. 70, 1151-1160(1989).
   PUBMED   2543772
REFERENCE   34
  AUTHORS   Gompels U.A.
  JOURNAL   Submitted (13-DEC-1994) to the INSDC. U.A. Gompels, Viral
            Pathogenesis Unit, Department of Clinical Sciences, London School
            of Hygiene and Tropical Medicine, University of London, Keppel
            Street, London WC1E 7HT, UK
  REMARK    (1-159321)
REFERENCE   35
  AUTHORS   Tweedy J.G., Escriva E., Topf M., Gompels U.A.
  TITLE     Analyses of Tissue Culture Adaptation of Human Herpesvirus-6A by
            Whole Genome Deep Sequencing Redefines the Reference Sequence and
            Identifies Virus Entry Complex Changes
  JOURNAL   Viruses 10(1), E16-E16(2017).
   PUBMED   29301233
FEATURES             Qualifiers
     source          /organism="Human betaherpesvirus 6A"
                     /host="Homo sapiens"
                     /isolate="U1102"
                     /mol_type="genomic DNA"
                     /country="Uganda"
                     /db_xref="taxon:32603"
     protein         /gene="U31"
                     /function="large tegument protein"
                     /note="HHRF1; similar to HCMV UL48 ( high molecular weight
                     protein, HMWP), HVS GENE 64, EBV BPLF1, EHV1 24, VZV 22,
                     HSV1 UL36"
                     /db_xref="GOA:P52340"
                     /db_xref="InterPro:IPR006928"
                     /db_xref="InterPro:IPR034702"
                     /db_xref="InterPro:IPR038765"
                     /db_xref="UniProtKB/Swiss-Prot:P52340"
BEGIN
        1 MKIITSSTNQ NDSKYGPRAG KQCMSNSFSF LHTVYLNGIN NSLNAGTIDA IMEEGYHLDT
       61 AGTLALMLNN SDSQDYRLPT EIPKRIHSRY GVTQHELSRP FNGTLDTQKI DNEVYLGLID
      121 FILYGKSKNG PTFAVITIGV LSRALFFLNN TLYLFDSHPT EREATAAIYI CQNIEEVYEL
      181 LTTHGTEGFY YDASLIFFIE TSNLSLSSHD AELLILKTYK DPDIAIALDK FSSTEIHEIK
      241 KTDDIGSQQD LVADKTTDLE HAPHKRKKNS HSLELELNDK KKKDTASLTY YATEVDLIPS
      301 FYELRSQFQS LFHDLKSFPI MKSNFNWTIY LQDSPINPNQ PFATPFLWNR VFHLLCQIID
      361 VFVGVGSTND DSSKQQQQTI FINYLLPFKD FSEVFNEALA ACQENNLDII FIYNNYLCKT
      421 TTFRTLERIL LSKFLAIVDN DHKKHYEWVK SWTTQMFQGM PKKLDDIENY LKAYVDHNPV
      481 KHFHEFICLN KAEKYKVAVL LNEKRKEIQE AIEREKNSFA QLSNFIDKLG ETPALPIESE
      541 NVHKVHTSDI TEGIVPRFIT ESIELPNIST LNNTQQISLD KQLNEKLTNT IHTLTNKFTK
      601 IVQDNYNNIA AGFMPVTELN CLFAYLVNLY FNIEVLKHSG LNINTVLLQE VEKLYDNTQF
      661 LRFGTSHFNI NNLSNFTLSI RKMFVDFYNS QKPSDRASEI LAAIESILAD PSKNKTVVNI
      721 EMIKSQLEEL GKMEISTTEN KQTAAITKQI LGDQELTPIY DFLHHLSAYN LPNTTTVKNL
      781 HLHFILEQRP DIAMTLHDKI QSILDIYVDD MLNDITVPEQ TFSTVLFLVD LFPNSTEKTA
      841 LFESVLTLRQ LAKKCANLKT LDEFDDLAQF ITTNSEQLQN MMRQHFGKKI PTLMGHIKFL
      901 YSQKIITTEE KNWIQRAKTV VITSPEELTA FLATAPTKHA LQTCKPDLDK ALQRHMEEQM
      961 KQTAENDKKH ILTIRSTLEK RLTDILLILK DGQFSSLETM HLNLLETFLK QLQDNNVIIH
     1021 FTHALLPVLK DIETTISKII SDVIEKILIK TPLNPEQMSK EEQKYTPLLS FLSKFKKTTF
     1081 CTEDVKTEIE QVQKSITFLK KIATSTNKHT RLSHSIYGQE LNLYEERITE LRKETNKMKE
     1141 QLSKEYALAE KKILLSSQDA KTDKIYLVLN THTLKEIKNT QFKETAFAKA LTVEVNNKEN
     1201 QLQELLNHFN AHLKAKMDQN HITKLSFDTK WTAFVSDSRL YIPDFINIKL QDFISDPFKV
     1261 ISQLMNKATN EMPYIQAEIT LKWLTKLIHD INKFCLSAIS EFGKEAIPFN YAALRDLEYQ
     1321 INTKYVEIEN KVICNETVEN TKNIPKLTKL LKQLDPKRVA GGQEQYQTLM NKILTSETSM
     1381 QQTYEKEQLK KEYFEIVNNV ASFKLAFNFP QQLQNVERLI EKFKSLPKSQ PFEKFPQEND
     1441 LLSDSLNTEN YINGLRALLN FITAAQNYIQ NTLLKQWAVF QQQNFIPIDY SVANVKPISD
     1501 LYARLRIERE RQVFYQVNSV FGTHLIVDDT GVPLQFHNIF NNAIVKFFSL NYKQINVPED
     1561 TPRLVSSQYK LLSVCKSFIM ILQQFWENII TLDLGPYLRD GTQNFKRELI PIVNLKLFIY
     1621 CITQAWTASE DSTVSTAFEL PIKQFTLLIL CSHPEYLYGC LSHSTDLVIN SLAKSIDKNS
     1681 LYNTFVVSHN PPEKPMHLMR NICIDTQLWQ PAKLMKDTFQ QTFFTQLCPK NEKFFIYLTA
     1741 FLILPYKFMN YIWIQYKPAI FTQRSYQNLI KDLCSEYVHQ NKITTSSVTP HEPDTIKSGE
     1801 RITSKITVHK AQNTPTLTRL QAQEYVFDYI LYSFLTGYEM TFAMYIDIIE KTYLLCMRHL
     1861 ENVLHDKDFQ SVLRARTFDI DYILKQSWTK NIVEHSLFSV QLDKIVSYLN HTNRATPNIP
     1921 LILFNYDNEV VNVYLPPMST NPKKVAFYIK NPFHFPVQEY EATNLISFHL YPKTTDILNQ
     1981 LPPNNTESTR PGKQTSETLT NKNLSEPKFK KPAVTGLMPK SQSIILSTDT NVPETSPDVK
     2041 ANTASAAIKD VTLAREKINE FSESINTTIS KLKSMYL
//