LOCUS CAA58335.2 1452 aa PRT VRL 08-FEB-2018 DEFINITION Human betaherpesvirus 6A immediate early protein IE2 protein. ACCESSION X83413-81 PROTEIN_ID CAA58335.2 SOURCE Human betaherpesvirus 6A ORGANISM Human betaherpesvirus 6A Viruses; Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus. REFERENCE 1 (bases 1 to 159378) AUTHORS Gompels U.A., Nicholas J., Lawrence G., Jones M., Thomson B.J., Martin M.E., Efstathiou S., Craxton M., Macaulay H.A. TITLE The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution JOURNAL Virology 209(1), 29-51(1995). PUBMED 7747482 REFERENCE 2 AUTHORS Lawrence G.L., Chee M., Craxton M.A., Gompels U.A., Honess R.W., Barrell B.G. TITLE Human herpesvirus 6 is closely related to human cytomegalovirus JOURNAL J. Virol. 64(1), 287-299(1990). PUBMED 2152817 REFERENCE 3 AUTHORS Chang C.K., Balachandran N. TITLE Identification, characterization, and sequence analysis of a cDNA encoding a phosphoprotein of human herpesvirus 6 JOURNAL J. Virol. 65(6), 2884-2894(1991). PUBMED 1851860 REFERENCE 4 AUTHORS Teo I.A., Griffin B.E., Jones M.D. TITLE Characterization of the DNA polymerase gene of human herpesvirus 6 JOURNAL J. Virol. 65(9), 4670-4680(1991). PUBMED 1651403 REFERENCE 5 AUTHORS Thomson B.J., Efstathiou S., Honess R.W. TITLE Acquisition of the human adeno-associated virus type-2 rep gene by human herpesvirus type-6 JOURNAL Nature 351(6321), 78-80(1991). PUBMED 1851252 REFERENCE 6 AUTHORS Martin M.E.D., Nicholas J., Thomson B.J., Newman C., Honess R.W. TITLE Identification of a transactivating function mapping to the putative immediate-early locus of human herpesvirus 6 JOURNAL J. Virol. 65(10), 5381-5390(1991). PUBMED 1654446 REFERENCE 7 AUTHORS Efstathiou S., Lawrence G.L., Brown C.M., Barrell B.G. TITLE Identification of homologs to the human cytomegalovirus US22 gene family in human helpesvirus-6 JOURNAL J. Gen. Virol. 73, 1661-1671(1992). PUBMED 1321206 REFERENCE 8 AUTHORS Geng Y., Chandran B., Josephs S.F., Wood C. TITLE Identification and characterization of a human herpesvirus 6 gene segment that trans activates the human immunodeficiency virus type 1 promoter JOURNAL J. Virol. 66(3), 1564-1570(1992). PUBMED 1310766 REFERENCE 9 AUTHORS Gompels U.A., Carss A.L., Sun N., Arrand J.R. TITLE Infectivity determinants encoded in a conserved gene block of human herpesvirus-6 JOURNAL DNA Seq 3(1), 25-39(1992). PUBMED 1333836 REFERENCE 10 AUTHORS Neipel F., Ellinger K., Fleckenstein B. TITLE Gene for the major antigenic structural protein (p100) of human herpesvirus 6 JOURNAL J. Virol. 66(6), 3918-3924(1992). PUBMED 1374813 REFERENCE 11 AUTHORS Thomson B.J., Honess R.W. TITLE The right end of the unique region of the genome of human herpesvirus 6 U1102 contains a candidate immediate early gene enhancer and a homologue of the human cytomegalovirus US22 gene family JOURNAL J. Gen. Virol. 73, 1649-1660(1992). PUBMED 1321205 REFERENCE 12 AUTHORS Ellinger K., Neipel F., Foa-Tomasi L., Campadelli-Fiume G., Fleckenstein B. TITLE The glycoprotein B homologue of human herpesvirus 6 JOURNAL J. Gen. Virol. 74, 495-500(1993). PUBMED 8383182 REFERENCE 13 AUTHORS Gompels U.A., Carrigan D.R., Carss A.L., Arno J. TITLE Two groups of human herpesvirus 6 identified by sequence analyses of laboratory strains and variants from Hodgkin's lymphoma and bone marrow transplant patients JOURNAL J. Gen. Virol. 74, 613-622(1993). PUBMED 8385692 REFERENCE 14 AUTHORS Liu D.X., Gompels U.A., Nicholas J., Lelliott C. TITLE Identification and expression of the human herpesvirus 6 glycoprotein H and interaction with an accessory 40K glycoprotein JOURNAL J. Gen. Virol. 74, 1847-1857(1993). PUBMED 8397282 REFERENCE 15 AUTHORS Liu D.X., Gompels U.A., Foa-Tomasi L., Campadelli-Fiume G. TITLE Human herpesvirus-6 glycoprotein H and L homologs are components of the gp100 complex and the gH external domain is the target for neutralizing monoclonal antibodies JOURNAL Virology 197(1), 12-22(1993). PUBMED 7692666 REFERENCE 16 AUTHORS Pellett P.E., Sanchez-Martinez D., Dominguez G., Black J.B., Anton E., Greenamoyer C., Dambaugh T.R. TITLE A strongly immunoreactive virion protein of human herpesvirus 6 variant B strain Z29: identification and characterization of the gene and mapping of a variant-specific monoclonal antibody reactive epitope JOURNAL Virology 195(2), 521-531(1993). PUBMED 7687803 REFERENCE 17 AUTHORS Pfeiffer B., Berneman Z.N., Neipel F., Chang C.K., Tirwatnapong S., Chandran B. TITLE Identification and mapping of the gene encoding the glycoprotein complex gp82-gp105 of human herpesvirus 6 and mapping of the neutralizing epitope recognized by monoclonal antibodies JOURNAL J. Virol. 67(8), 4611-4620(1993). PUBMED 7687301 REFERENCE 18 AUTHORS Gompels U.A., Macaulay H.A. TITLE Characterisation of human telomeric repeat sequences from human herpesvirus-6 and relationship to replication JOURNAL J. Gen. Virol. 76, 451-458(1995). PUBMED 7844567 REFERENCE 19 AUTHORS Dewhurst S., Dollard S.C., Pellett P.E., Dambaugh T.R. TITLE Identification of a lytic-phase origin of DNA replication in human herpesvirus 6B strain Z29 JOURNAL J. Virol. 67(12), 7680-7683(1993). PUBMED 8230490 REFERENCE 20 AUTHORS Nicholas J. TITLE Nucleotide sequence of a 21-kilobase-pair region of the genome of human herpesvirus-6 containing homologues of human cytomegalovirus major immediate-early and replication genes JOURNAL Unpublished. REFERENCE 21 AUTHORS Nicholas J., Martin M. TITLE Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions JOURNAL J. Virol. 68(2), 597-610(1994). PUBMED 8289364 REFERENCE 22 AUTHORS Schiewe U., Neipel F., Schreiner D., Fleckenstein B. TITLE Structure and transcription of an immediate-early region in the human herpesvirus 6 genome JOURNAL J. Virol. 68(5), 2978-2985(1994). PUBMED 8151768 REFERENCE 23 AUTHORS Thompson J., Choudhury S., Kashanchi F., Doniger J., Berneman Z., Frenkel N., Rosenthal L.J. TITLE A transforming fragment within the direct repeat region of human herpesvirus type 6 that transactivates HIV-1 JOURNAL Oncogene 9(4), 1167-1175(1994). PUBMED 8134119 REFERENCE 24 AUTHORS Zhou Y., Chang C.K., Qian G., Chandran B., Wood C. TITLE trans-activation of the HIV promoter by a cDNA and its genomic clones of human herpesvirus-6 JOURNAL Virology 199(2), 311-322(1994). PUBMED 8122364 REFERENCE 25 AUTHORS Thomson B.J., Dewhurst S., Gray D. TITLE Structure and heterogeneity of the a sequences of human herpesvirus 6 strain variants U1102 and Z29 and identification of human telomeric repeat sequences at the genomic termini JOURNAL J. Virol. 68(5), 3007-3014(1994). PUBMED 8151770 REFERENCE 26 AUTHORS Thomson B.J., Weindler F.W., Gray D., Schwaab V., Helbronn R. TITLE Human herpesvirus 6 (HHV-6) is a helper virus for adeno-associated virus type 2 (AAV-2) and the AAV-2 rep gene homologue in HHV-6 can mediate AAV-2 DNA replication and regulate gene expression JOURNAL Virology 204(1), 304-311(1994). PUBMED 8091661 REFERENCE 27 AUTHORS Inoue N., Dambaugh T.R., Rapp J.C., Pellett P.E. TITLE Alphaherpesvirus origin-binding protein homolog encoded by human herpesvirus 6B, a betaherpesvirus, binds to nucleotide sequences that are similar to ori regions of alphaherpesviruses JOURNAL J. Virol. 68(7), 4126-4136(1994). PUBMED 8207791 REFERENCE 28 AUTHORS Lawrence G.L., Nicholas J., Barrell B.G. TITLE Human herpesvirus 6 (strain U1102) encodes homologues of the conserved herpesvirus glycoprotein gM and the alphaherpesvirus origin-binding protein JOURNAL J. Gen. Virol. 0, 0(1994). REFERENCE 29 AUTHORS Qian G., Wood C., Chandran B. TITLE Identification and characterization of glycoprotein gH of human herpesvirus-6 JOURNAL J. Virol. 194, 380-386(1993). REFERENCE 30 AUTHORS Jones M., Teo I. TITLE Identification and analysis of the transport/capsid assembly protein (tp/cap) gene of human herpesvirus-6 (HHV6) JOURNAL Virology 197(1), 449-454(1993). PUBMED 8212582 REFERENCE 31 AUTHORS Littler E., Lawrence G., Liu M.Y., Barrell B.G., Arrand J.R. TITLE Identification, cloning, and expression of the major capsid protein gene of human herpesvirus 6 JOURNAL J. Virol. 64(2), 714-722(1990). PUBMED 2153237 REFERENCE 32 AUTHORS Martin M., Thomson B.J., Honess R.W., Craxton M.A., Gompels U.A., Liu M.Y., Littler E., Arrand J.R., Teo I., Jones M.D. TITLE The genome of human herpesvirus 6: Maps of unit-length and concatemeric genomes for nine restriction endonucleases JOURNAL J. Gen. Virol. 72, 157-168(1991). PUBMED 1846644 REFERENCE 33 AUTHORS Chee M.S., Lawrence G.L., Barrell B.G. TITLE Alpha-, beta- and gammaherpesviruses encode a putative phosphotransferase JOURNAL J. Gen. Virol. 70, 1151-1160(1989). PUBMED 2543772 REFERENCE 34 AUTHORS Gompels U.A. JOURNAL Submitted (13-DEC-1994) to the INSDC. U.A. Gompels, Viral Pathogenesis Unit, Department of Clinical Sciences, London School of Hygiene and Tropical Medicine, University of London, Keppel Street, London WC1E 7HT, UK REMARK (1-159321) REFERENCE 35 AUTHORS Tweedy J.G., Escriva E., Topf M., Gompels U.A. TITLE Analyses of Tissue Culture Adaptation of Human Herpesvirus-6A by Whole Genome Deep Sequencing Redefines the Reference Sequence and Identifies Virus Entry Complex Changes JOURNAL Viruses 10(1), E16-E16(2017). PUBMED 29301233 FEATURES Qualifiers source /organism="Human betaherpesvirus 6A" /host="Homo sapiens" /isolate="U1102" /mol_type="genomic DNA" /country="Uganda" /db_xref="taxon:32603" protein /gene="U86" /function="transactivation" /note="BCLF1; similar to HHV-5 UL122, IE2; region IE-A, immediate early gene" /db_xref="GOA:Q77Z83" /db_xref="InterPro:IPR005028" /db_xref="InterPro:IPR005507" /db_xref="InterPro:IPR026075" /db_xref="PDB:5WX8" /db_xref="UniProtKB/Swiss-Prot:Q77Z83" intron_pos 20:2 (1/2) intron_pos 85:1 (2/2) BEGIN 1 MEPAKPSGNN MGSNDERMQD YRPDPMMEES IKEILEESLM CDTSFDDLII PGLESFGLII 61 PESSNNIESN NVEEGSDGEL KTLAEQKCKQ GNDNDVIQSA MKLSGLYCDA DITHTQPLSD 121 NTHQDPIYSQ ESRIFSKTIQ DPRIVAQTHR QCTSSASNLQ SNESGSTQVR FASELPNQLL 181 QPMYTSHNQN ANLQNNFTSL PYQPYHDPYR DIESSYRESR NTNRGYDYNF RHHPYRPRGG 241 NGKYNYYNPN SKYQQPYKRC FTRTYNRRGR GHRSYDCSDR SADLPYEHYT YPNYEQQNPD 301 PRMNNYKDFT QLTNKFNFES YDYSMAFSTD STHVQSDNYN HPTKAQTIPE TTKTKKHEAT 361 KDNETSTENQ VLTPDVISLS YRPSSYKMDI IKKIYDTDVI PLPKEALTAN GSNRDVDIQK 421 YKKAHIRCRS VQKKKERSSQ TNKHDENHAS SRSDLKERKS NENEDKAVTK ARDFSKLNPL 481 LSPLPLTPEP AIDFADHTDK FYSTPEFNQI QQNLHRSKTS LQDTVPISKH TPRAPTKDNS 541 YKKHHDSKDN YPKMKHSPGR TTSKKNTTNS NGHQNFKEVS VKNVSGKATS TSPKSKTHHY 601 SSSSDEEGQY KSPVKTIIQS PSPYCKLKNP SIMDKNSAKN HTASADKNLT DNSPIRSNLN 661 PTAFNKSNSN KSITNSTSNS DECTDRKPNC NSTKNESKDP NRTCGKNSDK HLSKSCTMAS 721 KRAPSRASSR ASSRDSSRAS SRASSRASSR DSSRASSRAS SRDSSRASSR ASSRASSKAS 781 SRASSRASSR ASSRDSSRAS SKASSRASSR DSSRASSRDS SRDSSRASSR ASSRDSSRAS 841 SKASRKASSR ASSRASSRAS SKASGKASSE ASSRASSRNS SRASSRASSR ASSRDSSRAS 901 SRASSRDSSR ASSKASRKAS SRASSRASSR ELRQIYCDSN KRQTPPHDTS INTKFEISEI 961 KFRCGEDLNF YKNTAARLQC FNHNDQFYNP RFRPHIRTNR KKSESTNDTD SESSMSRCKS 1021 HCRNSPDSLT VVRRKKHKSG SSSISSSIEE NCRSNSHIVT GKEKFTPFYY QSSRTRSSSS 1081 SSSSSASLSC SKSTLKTCRK TQYKDNKQIK SKSDSKHKTT NMSSDYESNR HADVFKNSPE 1141 AGEKFPLHNS SPFNTHEQSN HSENAIDEEQ KKAPNITTSH LQGKQNVRLH NTKKCKKKRP 1201 RDDDSDSSIK NFCKKRISGA QKTESEVSEP DDLCYRDYVR LKERKVSEKF KIHRGRVATK 1261 DFQKLFRNTM RAFEYKQIPK KPCNEKNLKE AVYDICCNGL SNNAAIIMYF TRSKKVAQII 1321 KIMQKELMIR PNITVSEAFK MNHAPPKYYD KDEIKRFIQL QKQGPQELWD KFENNTTHDL 1381 FTRHSDVKTM IIYAATPIDF VGAVKTCNKY AKDNPKEIVL RVCSIIDGDN PISIYNPISK 1441 EFKSKFSTLS KC //