LOCUS       CAA48197.1              1621 aa    PRT              HUM 21-OCT-2008
DEFINITION  Homo sapiens DNA topoisomerase II protein.
ACCESSION   X68060-1
PROTEIN_ID  CAA48197.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4866)
  AUTHORS   Jenkins J.R.
  JOURNAL   Submitted (14-AUG-1992) to the INSDC. J.R. Jenkins, ICRF Inst of
            Mol Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU,
            UK
REFERENCE   2  (bases 1 to 4866)
  AUTHORS   Jenkins J.R., Ayton P., Jones T., Davies S.L., Simmons D.L.,
            Harris A.L., Sheer D., Hickson I.D.
  TITLE     Isolation of cDNA clones encoding the beta isozyme of human DNA
            topoisomerase II and localisation of the gene to chromosome 3p24
  JOURNAL   Nucleic Acids Res. 20(21), 5587-5592(1992).
   PUBMED   1333583
FEATURES             Qualifiers
     source          /db_xref="H-InvDB:HIT000322912"
                     /organism="Homo sapiens"
                     /chromosome="3p24"
                     /mol_type="mRNA"
                     /clone_lib="NBC"
                     /clone="pT2b-1"
                     /cell_type="EBV-transformed"
                     /db_xref="taxon:9606"
     protein         /gene="topIIb"
                     /note="antitumor drug target"
                     /db_xref="GOA:Q02880"
                     /db_xref="H-InvDB:HIT000322912.14"
                     /db_xref="HGNC:HGNC:11990"
                     /db_xref="InterPro:IPR001241"
                     /db_xref="InterPro:IPR002205"
                     /db_xref="InterPro:IPR003594"
                     /db_xref="InterPro:IPR006171"
                     /db_xref="InterPro:IPR012542"
                     /db_xref="InterPro:IPR013506"
                     /db_xref="InterPro:IPR013757"
                     /db_xref="InterPro:IPR013758"
                     /db_xref="InterPro:IPR013759"
                     /db_xref="InterPro:IPR013760"
                     /db_xref="InterPro:IPR014721"
                     /db_xref="InterPro:IPR018522"
                     /db_xref="InterPro:IPR020568"
                     /db_xref="InterPro:IPR031660"
                     /db_xref="InterPro:IPR034157"
                     /db_xref="InterPro:IPR036890"
                     /db_xref="PDB:3QX3"
                     /db_xref="PDB:4G0U"
                     /db_xref="PDB:4G0V"
                     /db_xref="PDB:4G0W"
                     /db_xref="PDB:4J3N"
                     /db_xref="PDB:5GWI"
                     /db_xref="PDB:5GWJ"
                     /db_xref="PDB:5ZAD"
                     /db_xref="PDB:5ZEN"
                     /db_xref="PDB:5ZQF"
                     /db_xref="PDB:5ZRF"
                     /db_xref="UniProtKB/Swiss-Prot:Q02880"
BEGIN
        1 MAKSGGCGAG AGVGGGNGAL TWVNNAAKKE ESETANKNDS SKKLSVERVY QKKTQLEHIL
       61 LRPDTYIGSV EPLTQFMWVY DEDVGMNCRE VTFVPGLYKI FDEILVNAAD NKQRDKNMTC
      121 IKVSIDPESN IISIWNNGKG IPVVEHKVEK VYVPALIFGQ LLTSSNYDDD EKKVTGGRNG
      181 YGAKLCNIFS TKFTVETACK EYKHSFKQTW MNNMMKTSEA KIKHFDGEDY TCITFQPDLS
      241 KFKMEKLDKD IVALMTRRAY DLAGSCRGVK VMFNGKKLPV NGFRSYVDLY VKDKLDETGV
      301 ALKVIHELAN ERWDVCLTLS EKGFQQISFV NSIATTKGGR HVDYVVDQVV GKLIEVVKKK
      361 NKAGVSVKPF QVKNHIWVFI NCLIENPTFD SQTKENMTLQ PKSFGSKCQL SEKFFKAASN
      421 CGIVESILNW VKFKAQTQLN KKCSSVKYSK IKGIPKLDDA NDAGGKHSLE CTLILTEGDS
      481 AKSLAVSGLG VIGRDRYGVF PLRGKILNVR EASHKQIMEN AEINNIIKIV GLQYKKSYDD
      541 AESLKTLRYG KIMIMTDQDQ DGSHIKGLLI NFIHHNWPSL LKHGFLEEFI TPIVKASKNK
      601 QELSFYSIPE FDEWKKHIEN QKAWKIKYYK GLGTSTAKEA KEYFADMERH RILFRYAGPE
      661 DDAAITLAFS KKKIDDRKEW LTNFMEDRRQ RRLHGLPEQF LYGTATKHLT YNDFINKELI
      721 LFSNSDNERS IPSLVDGFKP GQRKVLFTCF KRNDKREVKV AQLAGSVAEM SAYHHGEQAL
      781 MMTIVNLAQN FVGSNNINLL QPIGQFGTRL HGGKDAASPR YIFTMLSTLA RLLFPAVDDN
      841 LLKFLYDDNQ RVEPEWYIPI IPMVLINGAE GIGTGWACKL PNYDAREIVN NVRRMLDGLD
      901 PHPMLPNYKN FKGTIQELGQ NQYAVSGEIF VVDRNTVEIT ELPVRTWTQV YKEQVLEPML
      961 NGTDKTPALI SDYKEYHTDT TVKFVVKMTE EKLAQAEAAG LHKVFKLQTT LTCNSMVLFD
     1021 HMGCLKKYET VQDILKEFFD LRLSYYGLRK EWLVGMLGAE STKLNNQARF ILEKIQGKIT
     1081 IENRSKKDLI QMLVQRGYES DPVKAWKEAQ EKAAEEDETQ NQHDDSSSDS GTPSGPDFNY
     1141 ILNMSLWSLT KEKVEELIKQ RDAKGREVND LKRKSPSDLW KEDLAAFVEE LDKVESQERE
     1201 DVLAGMSGKA IKGKVGKPKV KKLQLEETMP SPYGRRIIPE ITAMKADASK KLLKKKKGDL
     1261 DTAAVKVEFD EEFSGAPVEG AGEEALTPSV PINKGPKPKR EKKEPGTRVR KTPTSSGKPS
     1321 AKKVKKRNPW SDDESKSESD LEETEPVVIP RDSLLRRAAA ERPKYTFDFS EEEDDDADDD
     1381 DDDNNDLEEL KVKASPITND GEDEFVPSDG LDKDEYTFSP GKSKATPEKS LHDKKSQDFG
     1441 NLFSFPSYSQ KSEDDSAKFD SNEEDSASVF SPSFGLKQTD KVPSKTVAAK KGKPSSDTVP
     1501 KPKRAPKQKK VVEAVNSDSD SEFGIPKKTT TPKGKGRGAK KRKASGSENE GDYNPGRKTS
     1561 KTTSKKPKKT SFDQDSDVDI FPSDFPTEPP SLPRTGRARK EVKYFTESDE EEDDVDFAMF
     1621 N
//