LOCUS CAA30801.1 1927 aa PRT HUM 07-OCT-2008
DEFINITION Homo sapiens protein ( Human mRNA for lactase-phlorizin
hydrolase LPH (EC 3.2.1.23-62). ).
ACCESSION X07994-1
PROTEIN_ID CAA30801.1
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6274)
AUTHORS Mantei N.
JOURNAL Submitted (28-JUN-1988) to the INSDC. Mantei N., Swiss Federal
Institute of Technology Zurich, Universitaetstrasse 16,
ETH-Zentrum, CH-8092 Zurich, Switzerland.
REFERENCE 2
AUTHORS Mantei N., Villa M., Enzler T., Wacker H., Boll W., James P.,
Hunziker W., Semenza G.
TITLE Complete primary structure of human and rabbit lactase-phlorizin
hydrolase: implications for biosynthesis, membrane anchoring and
evolution of the enzyme
JOURNAL EMBO J. 7(9), 2705-2713(1988).
PUBMED 2460343
COMMENT Data kindly reviewed (12-DEC-1988) by Mantei N.
FEATURES Qualifiers
source /db_xref="H-InvDB:HIT000321293"
/organism="Homo sapiens"
/mol_type="mRNA"
/dev_stage="adult"
/clone="pHLac-61, pHLac-5, pHLac-1"
/tissue_type="intestinal mucosa"
/db_xref="taxon:9606"
protein /note="LPH prepro-polypeptide (AA -19 to 1908)"
/db_xref="GOA:P09848"
/db_xref="H-InvDB:HIT000321293.15"
/db_xref="HGNC:HGNC:6530"
/db_xref="InterPro:IPR001360"
/db_xref="InterPro:IPR017853"
/db_xref="InterPro:IPR018120"
/db_xref="InterPro:IPR033132"
/db_xref="UniProtKB/Swiss-Prot:P09848"
BEGIN
1 MELSWHVVFI ALLSFSCWGS DWESDRNFIS TAGPLTNDLL HNLSGLLGDQ SSNFVAGDKD
61 MYVCHQPLPT FLPEYFSSLH ASQITHYKVF LSWAQLLPAG STQNPDEKTV QCYRRLLKAL
121 KTARLQPMVI LHHQTLPAST LRRTEAFADL FADYATFAFH SFGDLVGIWF TFSDLEEVIK
181 ELPHQESRAS QLQTLSDAHR KAYEIYHESY AFQGGKLSVV LRAEDIPELL LEPPISALAQ
241 DTVDFLSLDL SYECQNEASL RQKLSKLQTI EPKVKVFIFN LKLPDCPSTM KNPASLLFSL
301 FEAINKDQVL TIGFDINEFL SCSSSSKKSM SCSLTGSLAL QPDQQQDHET TDSSPASAYQ
361 RVWEAFANQS RAERDAFLQD TFPEGFLWGA STGAFNVEGG WAEGGRGVSI WDPRRPLNTT
421 EGQATLEVAS DSYHKVASDV ALLCGLRAQV YKFSISWSRI FPMGHGSSPS LPGVAYYNKL
481 IDRLQDAGIE PMATLFHWDL PQALQDHGGW QNESVVDAFL DYAAFCFSTF GDRVKLWVTF
541 HEPWVMSYAG YGTGQHPPGI SDPGVASFKV AHLVLKAHAR TWHHYNSHHR PQQQGHVGIV
601 LNSDWAEPLS PERPEDLRAS ERFLHFMLGW FAHPVFVDGD YPATLRTQIQ QMNRQCSHPV
661 AQLPEFTEAE KQLLKGSADF LGLSHYTSRL ISNAPQNTCI PSYDTIGGFS QHVNHVWPQT
721 SSSWIRVVPW GIRRLLQFVS LEYTRGKVPI YLAGNGMPIG ESENLFDDSL RVDYFNQYIN
781 EVLKAIKEDS VDVRSYIARS LIDGFEGPSG YSQRFGLHHV NFSDSSKSRT PRKSAYFFTS
841 IIEKNGFLTK GAKRLLPPNT VNLPSKVRAF TFPSEVPSKA KVVWEKFSSQ PKFERDLFYH
901 GTFRDDFLWG VSSSAYQIEG AWDADGKGPS IWDNFTHTPG SNVKDNATGD IACDSYHQLD
961 ADLNMLRALK VKAYRFSISW SRIFPTGRNS SINSHGVDYY NRLINGLVAS NIFPMVTLFH
1021 WDLPQALQDI GGWENPALID LFDSYADFCF QTFGDRVKFW MTFNEPMYLA WLGYGSGEFP
1081 PGVKDPGWAP YRIAHTVIKA HARVYHTYDE KYRQEQKGVI SLSLSTHWAE PKSPGVPRDV
1141 EAADRMLQFS LGWFAHPIFR NGDYPDTMKW KVGNRSELQH LATSRLPSFT EEEKRFIRAT
1201 ADVFCLNTYY SRIVQHKTPR LNPPSYEDDQ EMAEEEDPSW PSTAMNRAAP WGTRRLLNWI
1261 KEEYGDIPIY ITENGVGLTN PNTEDTDRIF YHKTYINEAL KAYRLDGIDL RGYVAWSLMD
1321 NFEWLNGYTV KFGLYHVDFN NTNRPRTARA SARYYTEVIT NNGMPLARED EFLYGRFPEG
1381 FIWSAASAAY QIEGAWRADG KGLSIWDTFS HTPLRVENDA IGDVACDSYH KIAEDLVTLQ
1441 NLGVSHYRFS ISWSRILPDG TTRYINEAGL NYYVRLIDTL LAASIQPQVT IYHWDLPQTL
1501 QDVGGWENET IVQRFKEYAD VLFQRLGDKV KFWITLNEPF VIAYQGYGYG TAAPGVSNRP
1561 GTAPYIVGHN LIKAHAEAWH LYNDVYRASQ GGVISITISS DWAEPRDPSN QEDVEAARRY
1621 VQFMGGWFAH PIFKNGDYNE VMKTRIRDRS LAAGLNKSRL PEFTESEKRR INGTYDFFGF
1681 NHYTTVLAYN LNYATAISSF DADRGVASIA DRSWPDSGSF WLKMTPFGFR RILNWLKEEY
1741 NDPPIYVTEN GVSQREETDL NDTARIYYLR TYINEALKAV QDKVDLRGYT VWSAMDNFEW
1801 ATGFSERFGL HFVNYSDPSL PRIPKASAKF YASVVRCNGF PDPATGPHAC LHQPDAGPTI
1861 SPVRQEEVQF LGLMLGTTEA QTALYVLFSL VLLGVCGLAF LSYKYCKRSK QGKTQRSQQE
1921 LSPVSSF
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