LOCUS       CAA26669.1               233 aa    PRT              HUM 14-NOV-2006
DEFINITION  Homo sapiens TNF-alpha protein.
ACCESSION   X02910-1
PROTEIN_ID  CAA26669.1
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3634)
  AUTHORS   Nedwin G.E., Naylor S.L., Sakaguchi A.Y., Smith D.,
            Jarrett-Nedwin J., Pennica D., Goeddel D.V., Gray P.W.
  TITLE     Human lymphotoxin and tumor necrosis factor genes: structure,
            homology and chromosomal localization
  JOURNAL   Nucleic Acids Res. 13(17), 6361-6373(1985).
   PUBMED   2995927
REFERENCE   2  (bases 329 to 3634)
  AUTHORS   Shirai T., Yamaguchi H., Ito H., Todd C.W., Wallace R.B.
  TITLE     Cloning and expression in Escherichia coli of the gene for human
            tumour necrosis factor
  JOURNAL   Nature 313(6005), 803-806(1985).
   PUBMED   3883195
REFERENCE   3
  AUTHORS   Pennica D., Nedwin G.E., Hayflick J.S., Seeburg P.H., Derynck R.,
            Palladino M.A., Kohr W.J., Aggarwal B.B., Goeddel D.V.
  TITLE     Human tumour necrosis factor: precursor structure, expression and
            homology to lymphotoxin
  JOURNAL   Nature 312(5996), 724-729(1984).
   PUBMED   6392892
COMMENT     In the cDNA sequence from ref [3] the mature protein site starts
            also with Val at pos 1631
            Data kindly reviewed (18-FEB-1986) by A. Sakaguchi
FEATURES             Qualifiers
     source          /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
     protein         /db_xref="GOA:P01375"
                     /db_xref="HGNC:HGNC:11892"
                     /db_xref="InterPro:IPR002959"
                     /db_xref="InterPro:IPR006052"
                     /db_xref="InterPro:IPR006053"
                     /db_xref="InterPro:IPR008983"
                     /db_xref="InterPro:IPR021184"
                     /db_xref="PDB:1A8M"
                     /db_xref="PDB:1TNF"
                     /db_xref="PDB:2AZ5"
                     /db_xref="PDB:2E7A"
                     /db_xref="PDB:2TUN"
                     /db_xref="PDB:2ZJC"
                     /db_xref="PDB:2ZPX"
                     /db_xref="PDB:3ALQ"
                     /db_xref="PDB:3IT8"
                     /db_xref="PDB:3L9J"
                     /db_xref="PDB:3WD5"
                     /db_xref="PDB:4G3Y"
                     /db_xref="PDB:4TSV"
                     /db_xref="PDB:4TWT"
                     /db_xref="PDB:4Y6O"
                     /db_xref="PDB:5M2I"
                     /db_xref="PDB:5M2J"
                     /db_xref="PDB:5M2M"
                     /db_xref="PDB:5MU8"
                     /db_xref="PDB:5TSW"
                     /db_xref="PDB:5UUI"
                     /db_xref="PDB:5WUX"
                     /db_xref="PDB:5YOY"
                     /db_xref="UniProtKB/Swiss-Prot:P01375"
     intron_pos      63:0 (1/3)
     intron_pos      78:1 (2/3)
     intron_pos      94:1 (3/3)
BEGIN
        1 MSTESMIRDV ELAEEALPKK TGGPQGSRRC LFLSLFSFLI VAGATTLFCL LHFGVIGPQR
       61 EEFPRDLSLI SPLAQAVRSS SRTPSDKPVA HVVANPQAEG QLQWLNRRAN ALLANGVELR
      121 DNQLVVPSEG LYLIYSQVLF KGQGCPSTHV LLTHTISRIA VSYQTKVNLL SAIKSPCQRE
      181 TPEGAEAKPW YEPIYLGGVF QLEKGDRLSA EINRPDYLDF AESGQVYFGI IAL
//