LOCUS CAA26669.1 233 aa PRT HUM 14-NOV-2006 DEFINITION Homo sapiens TNF-alpha protein. ACCESSION X02910-1 PROTEIN_ID CAA26669.1 SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3634) AUTHORS Nedwin G.E., Naylor S.L., Sakaguchi A.Y., Smith D., Jarrett-Nedwin J., Pennica D., Goeddel D.V., Gray P.W. TITLE Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization JOURNAL Nucleic Acids Res. 13(17), 6361-6373(1985). PUBMED 2995927 REFERENCE 2 (bases 329 to 3634) AUTHORS Shirai T., Yamaguchi H., Ito H., Todd C.W., Wallace R.B. TITLE Cloning and expression in Escherichia coli of the gene for human tumour necrosis factor JOURNAL Nature 313(6005), 803-806(1985). PUBMED 3883195 REFERENCE 3 AUTHORS Pennica D., Nedwin G.E., Hayflick J.S., Seeburg P.H., Derynck R., Palladino M.A., Kohr W.J., Aggarwal B.B., Goeddel D.V. TITLE Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin JOURNAL Nature 312(5996), 724-729(1984). PUBMED 6392892 COMMENT In the cDNA sequence from ref [3] the mature protein site starts also with Val at pos 1631 Data kindly reviewed (18-FEB-1986) by A. Sakaguchi FEATURES Qualifiers source /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" protein /db_xref="GOA:P01375" /db_xref="HGNC:HGNC:11892" /db_xref="InterPro:IPR002959" /db_xref="InterPro:IPR006052" /db_xref="InterPro:IPR006053" /db_xref="InterPro:IPR008983" /db_xref="InterPro:IPR021184" /db_xref="PDB:1A8M" /db_xref="PDB:1TNF" /db_xref="PDB:2AZ5" /db_xref="PDB:2E7A" /db_xref="PDB:2TUN" /db_xref="PDB:2ZJC" /db_xref="PDB:2ZPX" /db_xref="PDB:3ALQ" /db_xref="PDB:3IT8" /db_xref="PDB:3L9J" /db_xref="PDB:3WD5" /db_xref="PDB:4G3Y" /db_xref="PDB:4TSV" /db_xref="PDB:4TWT" /db_xref="PDB:4Y6O" /db_xref="PDB:5M2I" /db_xref="PDB:5M2J" /db_xref="PDB:5M2M" /db_xref="PDB:5MU8" /db_xref="PDB:5TSW" /db_xref="PDB:5UUI" /db_xref="PDB:5WUX" /db_xref="PDB:5YOY" /db_xref="UniProtKB/Swiss-Prot:P01375" intron_pos 63:0 (1/3) intron_pos 78:1 (2/3) intron_pos 94:1 (3/3) BEGIN 1 MSTESMIRDV ELAEEALPKK TGGPQGSRRC LFLSLFSFLI VAGATTLFCL LHFGVIGPQR 61 EEFPRDLSLI SPLAQAVRSS SRTPSDKPVA HVVANPQAEG QLQWLNRRAN ALLANGVELR 121 DNQLVVPSEG LYLIYSQVLF KGQGCPSTHV LLTHTISRIA VSYQTKVNLL SAIKSPCQRE 181 TPEGAEAKPW YEPIYLGGVF QLEKGDRLSA EINRPDYLDF AESGQVYFGI IAL //