LOCUS BAC70609.1 4840 aa PRT BCT 07-OCT-2016
DEFINITION Streptomyces avermitilis MA-4680 = NBRC 14893 modular
polyketide synthase protein.
ACCESSION BA000030-2905
PROTEIN_ID BAC70609.1
SOURCE Streptomyces avermitilis MA-4680 = NBRC 14893
ORGANISM Streptomyces avermitilis MA-4680 = NBRC 14893
Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
Streptomycetaceae; Streptomyces.
REFERENCE 1 (bases 1 to 9025608)
AUTHORS Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M.
TITLE Direct Submission
JOURNAL Submitted (29-MAR-2002) to the DDBJ/EMBL/GenBank databases.
Contact:S Omura
Kitasato University, Kitasato Institute for Life Sciences; 1-15-1
Kitasato, Sagamihara, Kanagawa 228-8555, Japan
URL :http://avermitilis.ls.kitasato-u.ac.jp/
REFERENCE 2
AUTHORS Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H.,
Shiba,T., Sakaki,Y., Hattori,M. and Omura,S.
TITLE Complete Genome Sequence and Comparative Analysis of the
Industrial Microorganism Streptomyces avermitilis
JOURNAL Nat. Biotechnol. 21, 526-531 (2003)
REFERENCE 3
AUTHORS Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M.
TITLE Genome sequence of an industrial microorganism Streptomyces
avermitilis: Deducing the ability of producing secondary
metabolites
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 98, 12215-12220 (2001)
REFERENCE 4
AUTHORS Ikeda,H., Shin-ya,K. and Omura,S.
TITLE Genome mining of the Streptomyces avermitilis genome and
development of genome-minimized hosts for heterologous expression
of biosynthetic gene clusters
JOURNAL J. Ind. Microbiol. Biotechnol. 41, 233-250 (2014)
COMMENT This work was done in collaboration with Haruo Ikeda(*1),
Jun Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3),
Mayumi Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4),
Tomomi Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4),
Tadayoshi Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira
Hattori(*1,*7)
and Satoshi Omura(*1,*3).
Final finishing process and all annotation were done by H. Ikeda
and J. Ishikawa.
*1 Kitasato Institute for Life Sciences, Kitasato University
*2 National Institute of Infectious Diseases
*3 The Kitasato Institute
*4 National Institute of Technology and Evaluation
*5 School of Science, Kitasato University
*6 Institute of Medical Science, University of Tokyo
*7 RIKEN, Genomic Sciences Center
All the annotated genes identified are available from following
urls.
http://avermitilis.ls.kitasato-u.ac.jp
FEATURES Qualifiers
source /db_xref="taxon:227882"
/mol_type="genomic DNA"
/note="This strain is also named as strain: ATCC 31267,
NCIMB 12804 or NRRL 8165."
/organism="Streptomyces avermitilis MA-4680 = NBRC 14893"
/strain="MA-4680"
protein /gene="olmA2"
/locus_tag="SAVERM_2898"
/old_locus_tag="SAV_2898"
/transl_table=11
BEGIN
1 MDDDKLVDYL KRVTADLKRT RQRVQELEAG AAEPIAVVSM GCRFPGGIAS PEDLWECVRT
61 GTDTISGFPT DRGWRTGHLR GDFRLAGGFL ADAAGFDAGL FGISPREALA MDPQQRLLLE
121 TSWEVLERAG LDPTTVRGAD GGVFVGMADQ KYGPRDGELL DQVKGLVLTG TTSSVASGRI
181 AYSLGLQGPA ITIDTACSSS LVALHLAVRA LRSGECSFAL VGGAAVMAEP QLFAEMAEQG
241 GMAGDGRCKA FAAAADGTGW GEGVGVLLLQ PLSTAREQGL PVLATVRGTA VNQDGASNGL
301 TAPNGPAQRR VIRKALADAQ LSVGQVDAVE AHGTGTRLGD PIEAGALLAT YGQDRAGDEP
361 LWLGSVKSNI GHTQAAAGMA GVIKMVLAMR HGLLPRTLHV DEPTPQVDWS AGAVRLLTEE
421 QTWPSTGRPR RSAVSSFGIS GTNAHVVLEH DPAASGADGA PEPGPDTSPA APVPWTLSAA
481 SEEALRAQAR RLHRYADGDP GRRPLDIARS LARGRARLAH RAVVLGADRT ELLTSLAALG
541 AGEPDPRVVR GRTVPSGPVA FLFTGQGSQR AGIGRELYET FPVFARAFDE VRDRLDPQLA
601 HPLDDILDGR VVDGLPLIEQ TGYALAAVFA LEVALFRLVE HAGVVPDFVL GHSTGELAAA
661 HCAGVLSLDD ACTLVAARGR FVQTLRTDGA MVAVETSETE LAELIARADV GDRATIAVVN
721 GPRSVVVSGD ADAVERVRAR CEERGRKTRK LPISHAAHSV HMEPMLARLR EVAEGLEHRP
781 PRIPMVSNLT GAPVPPEANW PEYWVRQVRE TVRFHDGIRW LGAQGVTACL ELGPGGALIA
841 MARESLGDPG REVALVPTLQ HDRPEPATFL SALAELHVHG VAVDWDTPLA ARGATSTDLP
901 TYAFQRERYW LPATPAAPRT AEPADRTGRV RYRVGWTPYP DVDTDARPTG TWLVVAPDGD
961 SDGDGHGDGA RVAEALGERA VLLTAGPGLA PALARLPEDR PVAGVLALPA ESATRWTRLA
1021 PRSALRGRGA RPASVRHQAP VSVDTEAVPG AAPALLWGLG RVPHSGGGVV DLPAGLDARS
1081 LRLLAAVLAA PGDQDELAVR PGGVFARKLL PAQRPRRQRA WRTGGTVLIT GDIAGVTPEL
1141 LQYLSGGGAR TLLLAHRPGT PLPDAAVLAA AGGPCTVTEW DLGPLETASV TAVVHLSGID
1201 PDGPSTPDAL TAAGPARAVQ DRLRTVVRLE ELFHDADLDA FVLLSTVAGT WGGAEDLVHT
1261 VAHAALESLA ERRTLDGRPG TCVGWGPWET PADTGASPVP GLLPLPADLA VSALAEALDA
1321 DDPVCAVVDV DWSLFHPVLT GRGPRPLVAD LPEVRALPAP PTAEVVLAPA ADREHQLLEL
1381 VRAQAAAVLG HASGAAIDPV RPFRDLGFES LAAVRFRDRV AAETGLRLPA TLVFDHPTAQ
1441 AVAAHLLAEL SGVRQHEDEV APTADHDDPI AIVGMACRYP GGVRGPEDLW DLVHCGRDGV
1501 GDFPTDRGWD LPALRRLAPD LAMKGGFLPD AADFDAAFFG ISPREATAMD PQQRLLLEVS
1561 WQALEGAGLD PAALRGSRTG VFAGAAGSDY GVVLEGAPEA DGYLTTGTAA SVISGRIAYT
1621 LGLHGPAVTV DTACSSSLVA LHMAVGALHQ GECDLALATG VSVISTPGAF VDFARQSGLA
1681 ADGRCKAFAA SADGTNWAEG VGVLVVERLS DARRNGHRVL ATVRGSAVNS DGASNGLSAP
1741 NGGAQQRVIR QALAAAGLSA DDVDAVEAHG TGTTLGDPIE AQAVLATYGR DRPAGQPLWL
1801 GSLKSNIGHS GAAAGVGGVI KMVQALRHGV LPRTLHVDEP TPEVDWSAGT VGLLTENREW
1861 PHTGKPRRVG VSAFGVSGTN AHVVLEQGPE ETPEEAPEEA PEETPGEAPG ATAPPLLPWV
1921 LSARTPEALR AQAARLAARL AERELPAAAV GHALLTSRSD FEHRAVALGA GHGELTEALR
1981 AIAAGEPAGS TVTGVARRAA GRGPVFVFPG QGGQWPGMAA ELLDTAPEFA ARWAECERAL
2041 APYTGFSVTE LVRSGTPLER VDVVQPVLFA VMVSLAALWR SYGVVPAAVA GHSQGEIAAA
2101 CVAGALSLDD AARVVALRAQ ALRALVGEGG MVSVGIPLAE AERWLPRWDG QVSVAAVNGP
2161 SAVVFSGAPA ALDDLVAHAR DQDVRVRRID VDYASHSAQV ERIEDEIMTA LGPVRPGPGQ
2221 IPFFSTVTAD WQDPTGLDAA YWYRNLREPV LLEPSVTALA EQGYDVFVEV SPHPVLGAAL
2281 TETAELAGAE PVVTGTLRRD EGGLKRVRTA LAELWTHGVP VDWTPAFPGR HGTPVELPAY
2341 PFQRTRYWPA ARPAVAQDPQ DERFWQAVDQ QDLPTLAGTL GLADEQPLRE LVPALSAWRR
2401 DRKERAAVES WRYRIEWRRL PEPERRTLPG TWLLVVPTGT GTTDEPLTGT GTTDEPVTGA
2461 TTGGTADDPV TAAVTALLRE RAEQLVVLAV DPGSDPTTLA TALRGALGGT EPAGVVSLTG
2521 IDGSPHPERP VVPAGAALSL ALLRALADAR VTAPLWCLTH GAVTTDDDAG PVHPEQAAVW
2581 ALGRVAALEF PGTWGGLVDL PDPLDDRTAD RLAAVLAGLD GEDQVALRPS GVFGRRLVRA
2641 TPRATAGTGW RPRGTVLVTG GTGALGRRVA RWLAREGAEH LVLTSRRGPL APGADALVTE
2701 LTGLGVKVTL LSCDLADPAQ VTAMVAEAQR DGDPIGAVVH TAGGGGLGPL AEAGPDDLAE
2761 AMAAKVTGIA HLEAALDPEQ LDAVVYFSSI SASWGAGDHG VYAAANGVLD ARAEARSAAG
2821 VHTVSLAWAP WAGGGMADDP VFDTLSRKGL PLIDPDLAVS ALAAVLAEGE SSLLLVDVDW
2881 ERFTPQFTFE RPTRLLTELP EARPEPATDD TAPDTAASPL AQRLAALTGP QRTAALRDLV
2941 REQAAAVLGH ADARSVDPAR ALKELGFDSL TAVELRNRLS TATGLRLPAT MVFDHPTIAE
3001 LADFLARGLT PEAAVPAEPA TVVRVDQDDP IAIVAMACRY PGDVASAEDL WRAVRDEADL
3061 ITPFPTDRGW PLGRLVDAAD PDRPGTSYVG HGGFLHGAGD FDPGFFGISP REAQAMDPQH
3121 RLLLESSWEA LERAGIAPRS LRGSRTGVYV GLTDQAYGTR LRGSTDGMEG YLVSASANVA
3181 SGRISYSLGF QGPALTVDTA CSSSLVALHL AAQALRDGEC DLAIAGGATV MPDPTSFVAF
3241 SRQRGLAADG RCKPFAAAAD GFSLGEGAGV LLVERLSDAR RLGHPVLAVV RGSAVNQDGA
3301 SNGLTAPNGP AQERVIRQAL VNAALPASAV DVVEAHGTGT TLGDPIEAQA LLATYGQDRP
3361 AGRPLRLGSV KSNIGHSQAA AGVAGVIKMV QAMRHGLMPR TLHVDAPSPH VDWSSGAVEL
3421 LDRAQEWPRD GAPRRAGVSA FGISGTNAHV ILEEAPDTLE EAPDEPAGES TDERADEPTD
3481 ERADTDTGRP APGVSVPTAG RPVPVVVSAR TQDALRDQAA RLTALLDEGG HGVTDLAHSL
3541 ATTRSVLDRA AVLVAADPDE LRRGLTDLSA GAVAEERAEG RLAFLFTGQG AQRTGMGRAL
3601 YAAFPAFASA FDELCAALDR HLPRPLASVV FAEPGSPEAA LIDQTLYTQP ALFAVEVALF
3661 RLLEHWGVRP DAVLGHSIGE LAAAHVAGVW STADAARVVT ARARLMQELP EGGAMLSVAA
3721 AEDVVSALLG DAFDEVSVAA VNGPASMVLS GTEEAVTAAG ARLAEAGLRT KRLTVSHAFH
3781 SPLMEPMLAA YERELAQVTF AEPELPVVSN VTGKPATAEQ LCDPAYWARQ VRGTVRFADG
3841 VDSLLGEEVT TFLELGPDGV LTAMAKESAG AGATGIAVQR RDRDEVRTLL TALGRLHVRT
3901 GRVDWPAFFH GTGARRVELP TYAFQHRRYW LDAPTGGVEA LAGAGLAGTG HPLLTAAVPL
3961 PGTGGSLFSG SLPGIDEERP PSRGDILDLV LWAAGSLGCD RIAELDVPAA LPGGPHAPLQ
4021 LVVAAPDEDG DRDFTLHVGP TDSGDAGDES WTRIAHGTVG GAAARPEPDP AAWPPADAEP
4081 VGADAVWRRA DELFAELVLT EQEAGDADRF GLHPELLAGL TDLITELAGE PVHFAGVTRY
4141 ATGATELRVR LTRSGPGAVA VLLSDAEGEP VLSVDRVGVR TGTAPATTPA GAPTGPDSLY
4201 RLTWTPVAAV APEPAGPWAV VGADGLAKAL VATQGAEVEA HPDLASLGRS TEHGAAPGLV
4261 VLSVDTEPGA TVESMRHTTH RTLELVKELL ADGRLAGARF VLVTRAAVST GDGTPVDPAQ
4321 AAARGLLLSA QAEHPERFVL ADLGGRDADA ELLAAAVGTA LTEAEPQLAV RDGQVLVPRL
4381 AQVTERPTDG PAERGPGGEH GTVVVTGATG GIGTEIVRHL ATAHGVRHLL LLSRRGPDDP
4441 RAAELGRVLA EAGADATFTA CDTADRAALA DALADVPAEH PVTAVVHIAG VVDDGVLTTL
4501 TPDRIDTVLR PKAEAAQHLH ELTADLGLSH FVLFSSGVGT FGGAGQANYA AANAFLDALA
4561 HRRRAADLPA TSLAWGLWET TAGMSAHLSD VDRRRMAQAG VLAFTPRQGL ALFDAAWNSD
4621 ATTLVPMRLD KAVLRGKAAE ATLPAPFRGL VRAPLRRASA AGARAAGQSF AQQLAEQSES
4681 GRRQLLLDLI HRQVAAVLDY AADAPLDAKL PFRELGFDSL TAVELRNGLI AATGVQLSAA
4741 LVFDYPTATA LAEHLESKVL RSVAGAPLPA LTQLDHLEAA LATSPPDRAT REQLAARLRR
4801 LASAWSADEL EADDGDITSK LDSASDEELF DFINAEFGKD
//