LOCUS       BAC68129.1              7746 aa    PRT              BCT 07-OCT-2016
DEFINITION  Streptomyces avermitilis MA-4680 = NBRC 14893 modular
            polyketide synthase protein.
ACCESSION   BA000030-423
PROTEIN_ID  BAC68129.1
SOURCE      Streptomyces avermitilis MA-4680 = NBRC 14893
  ORGANISM  Streptomyces avermitilis MA-4680 = NBRC 14893
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9025608)
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2002) to the DDBJ/EMBL/GenBank databases.
            Contact:S Omura
            Kitasato University, Kitasato Institute for Life Sciences; 1-15-1
            Kitasato, Sagamihara, Kanagawa 228-8555, Japan
            URL    :http://avermitilis.ls.kitasato-u.ac.jp/
REFERENCE   2
  AUTHORS   Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H.,
            Shiba,T., Sakaki,Y., Hattori,M. and Omura,S.
  TITLE     Complete Genome Sequence and Comparative Analysis of the
            Industrial Microorganism Streptomyces avermitilis
  JOURNAL   Nat. Biotechnol. 21, 526-531 (2003)
REFERENCE   3
  AUTHORS   Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
            Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
            Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M.
  TITLE     Genome sequence of an industrial microorganism Streptomyces
            avermitilis: Deducing the ability of producing secondary
            metabolites
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 98, 12215-12220 (2001)
REFERENCE   4
  AUTHORS   Ikeda,H., Shin-ya,K. and Omura,S.
  TITLE     Genome mining of the Streptomyces avermitilis genome and
            development of genome-minimized hosts for heterologous expression
            of biosynthetic gene clusters
  JOURNAL   J. Ind. Microbiol. Biotechnol. 41, 233-250 (2014)
COMMENT     This work was done in collaboration with Haruo Ikeda(*1),
            Jun Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3),
            Mayumi Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4),
            Tomomi Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4),
            Tadayoshi Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira
            Hattori(*1,*7)
            and Satoshi Omura(*1,*3).
            Final finishing process and all annotation were done by H. Ikeda
            and J. Ishikawa.
            *1 Kitasato Institute for Life Sciences, Kitasato University
            *2 National Institute of Infectious Diseases
            *3 The Kitasato Institute
            *4 National Institute of Technology and Evaluation
            *5 School of Science, Kitasato University
            *6 Institute of Medical Science, University of Tokyo
            *7 RIKEN, Genomic Sciences Center
            All the annotated genes identified are available from following
            urls.
            http://avermitilis.ls.kitasato-u.ac.jp
FEATURES             Qualifiers
     source          /db_xref="taxon:227882"
                     /mol_type="genomic DNA"
                     /note="This strain is also named as strain: ATCC 31267,
                     NCIMB 12804 or NRRL 8165."
                     /organism="Streptomyces avermitilis MA-4680 = NBRC 14893"
                     /strain="MA-4680"
     protein         /gene="pteA1"
                     /locus_tag="SAVERM_419"
                     /old_locus_tag="SAV_419"
                     /transl_table=11
BEGIN
        1 MVESELNATG NRDCSASADS ADGIAVIGLA CRLPGAADPA AFWRLLSEGA DAITDVPPDR
       61 WDGAVVADAS APDRTGIRRG GFLDSIGDFD AGFFGLSPKE AAAMDPQQRL VLELAWEALE
      121 DAHVRAATLR STRTGVFVGA MWDDYATLHH RSGLTAISPH TVTGLHRSII ANRVSYFLGL
      181 NGPSLTVDSG QSSSLVSVHL ACESLRKGES TIALAGGVNL NIVPESALGA AKFGGLSPDG
      241 RCFTFDARAN GYVRGEGGGI VVLKPLARAV ADGDPVYCVI RGSAVNNDGG GDGLTVPLQS
      301 GQEQVLRLAY ERAGVNPADV GYVELHGTGT KVGDPIEAAA LGAVLGTGRE PGRPLRVGSA
      361 KTNVGHLEGA AGITGLLKAV LSLNHRELPA SLNFGTPNPA IPLDRLNLRV QTEHSEWAAE
      421 DGRPLLAGVS SFGMGGTNCH IVLASGAAVE AGEGATAGGG AAPTFWPLSA KTASGLRAQA
      481 AALLAHTEAP LGLALPDVGW SLATGRTAFE HRAVVVGEVR DDFLRALREL STGGIDAALT
      541 TGRAGPRGEL AFLFSGQGSQ RAGMGRELAE SVPAFASALD EVCAHLDPLL PRPLREVMFA
      601 PVGTGEAAEL DQTLYTQTSL FAVEVALFRL LESWDITPDV LMGHSIGELA AAHVAGVLSL
      661 ADACALVAAR GRLMQALPAG GAMIAVQAAE DEVRARIGER TDRVSIAALN GPDSVVVSGD
      721 EDLATEIADA FAALGRKTSR LRVSHAFHSP HMEPMLAEFR NVAEGLTFHA PRIPIVSNVT
      781 GRLSEEPSGY EGCTAAYWVR HVREAVRFAD GVARLDEQGV RTYLELGPGG VLASMARAGA
      841 DSESLFVPAL RTRRPEAQAL LAAVASLHVH GVEPDWDALF GGGRGARRKV ALPTYAFERQ
      901 RYWLDGDTTS PVATTGWAPV APQPDAIAET DSAPVGALGR RLAGLAESER DEAVLDMVRA
      961 HIAAVLGHAE ARQVETEWTF KDLGFDSLSS VELRNQLSEA TGLRLPSGLL FDHPTPAALA
     1021 RHLAAQSLGG GDAAAAAPAT VADPHEPIAI VAMSCRLPGG VSSPEDLWRL LASGGDGISG
     1081 FPTDRGWDVE TLYDPEPGTP GKSSTRHGGF LHEAAEFDAG FFGISPREAA AIDPQQRLVL
     1141 ETAWEAFERA GIDPATLRGS RAGVFIGATA QDYGPRLHEP ADGVEGYLLT GTTTSVASGR
     1201 VAYSFGLEGP AVTVDTACSS SLVALHLAVQ SLRSGECTMA LAGGVTVMST PGMFVEFSRQ
     1261 RGLSADGRCK AFAAGADGTG WAEGVGMLLV ERLSDARRNG HQVLAVVRGS AVNQDGASNG
     1321 LTAPNGPSQQ RVVRQALAAA GLAPADVDAV EAHGTGTLLG DPIEAEALIA AYGQGRDGDR
     1381 PLWLGSLKSN IGHTQAAAGV AGVIKMVMAM RHGVLPRTLH VDEPTPHVDW SASGVRLLTE
     1441 AVEWPARDLP RRAAVSSFGI SGTNAHVIVE QAATSEEPAR GTAVAGPVPW VVSAKSDVAL
     1501 REQAGRLLSF LDAEGVGGAG VRPEDVALSL ATSRAVLERR AAVVGGDLAE LRQGLEALAS
     1561 GASGAAPVGG AVGGRVGFLF SGQGSQRIGM GRELYAAYPV FAAAYDEVCA FLDAPVDVDS
     1621 EELNQTGTTQ PALFAVEVAL FRLLESWGIR PDYVAGHSVG EIAAAHVAGV LSLEDAAKLV
     1681 SARAALMQAL PDGGAMVAVQ ATEDEVLRHL TDGVGIAAVN GPRSVVVSGA EDAVTAVGEI
     1741 FAGRGRKTSR LKVSHAFHSP LMDPMLEEFA AVVRGLTFSE SRIPVVSNLT GRLAEVYTPE
     1801 YWVRHVREAV RFADGIETLG ELGVTTFVEV GPGGVLSALA QGCFDDGTDI VTVPVLRADR
     1861 PEPYALVTAI GRLHTHGISP DWQVLFPGAR RVDLPTYAFQ RERYWLDAPR AATAGAPDAM
     1921 DAEFWDSVES EDRASLGALL GLEPTELDVV ASKLSAWRRK RREQSTTDGW RYRITWQPLD
     1981 DMVRAAPSGT WLYVVSEETA WTEAIRAGLT ELGVALVPFA VGEDTDRDAL ARAFADAGQE
     2041 QADGILFAAA QGEAGANALQ RLVLLVQALG DAGIEAPLWC LTSGAVSTGT ADLLTDPVSA
     2101 QLWGLGRIVA LEQPQRWGGL VDLPAELDSR ALERLAGLLA QADEDQLAVR ASGVYGRRLV
     2161 RAPLSAAPAD APWSPRGTVL VTGGTGALGG QVARWLAGAG AEHLVLTSRR GPDAPGAAEL
     2221 KAELEELGAQ VTVVACDAAD RDALAELFGR YIVNAVVHTA GVLDDGLVES LTPERLNHVL
     2281 RPKVDAALHL HELTRDRQDL DAFVLFSSMT GVWGNGGQGA YGAANAFLDA LAEHRRAQGV
     2341 PALAVAWGSW ADGGMADGAA GDHLRRRGVR AIAALPAISV LHGALTHGET SMTVADVDWE
     2401 RFVPAFVGTR PCPLLLGVPE AREALEARAR AAQSPEVPVS ALVQRLLGAT PGEQGRILLD
     2461 LVREQAATVL GHTGKGAFEA DRTFRETGFD SLTAVELRHR LNTATGLRLP TTLVFDHPTP
     2521 TALARHLGEE LLGRHGLETA AAQATAAAAA DEPLAIVGMS CRLPGGVQSP EDLWELLSSG
     2581 RDAMSGFPTD RGWDIDALYD PDPDRPGKTY SREGGFIQGA DRFDAGLFGI SPREALAMDP
     2641 QQRLLLETAW EAFERAGIAL ASVRASRTGV FIGTNGQDYA NGLRNAPEEI EGYALTGKAA
     2701 SVVSGRISYT FGLEGPAVTV DTACSSSLVA LHLAAQALRS GECSMALVGG VTVMTTPDLF
     2761 VEFSRQRGLS PDGRCKAFAA GADGTGWGEG VGLLLVERLS DARRNGHQVL ALVRGSAVNQ
     2821 DGASNGLTAP NGPSQQRVIR QALASAGLTP ADVDAVEAHG TGTRLGDPIE AQALLATYGQ
     2881 EHSDDRPVWL GSVKSNIGHT QAAAGVAGVI KMVLAMRHGV LPQTLHVDEP TAHVDWSAGA
     2941 VRLLTEPVQW PGTTGPRRAA VSSFGIGGTN AHTIIEEAPA AAAAEPAREH RPVPVPWVLS
     3001 AKSEVALRAQ AERLLAFATD DVSPVDAGFS SATTRSALEH RAAVIGSDPA ELRAGLEALA
     3061 AGEPAANVVA GRAHSADKVG FLFSGQGSQR LGMGRELYAA YPVFAAAYDE VCALLDATVD
     3121 VDAETLHQTG STQPALFAVE VALFRLLESW GIRPDYVAGH SVGEIAAAHV AGVLSLEDAA
     3181 KLVSARAALM KALPAGGVMV AVQAAEDEML PHLIDRAGIA AINGPRSVVI SGAEDAVTAI
     3241 AEVFAAQGRK TSRLKVSHAF HSPLMDPMLE EFAEVVRGLT FSEPWIPVVS NLTGRLTESY
     3301 TPEYWVRHVR EAVRFADGVL TLHELGVTTF VEIGPGGVLS ALVQGCLDDG TDIVTIPALR
     3361 ADRPEPQALT TAYAQLHVSG AEVDWHAFFP GARRVELPTY AFQRERYWLD APASAGDMRA
     3421 VGQGEAGHPL LGAAVPLADS VGHLLTGRLS KHTHPWLVDH AVSGVALLPG TAFVELAITA
     3481 ADAVGCDLLE ELTLETPLLV PERGGVALQV HVGADDGSGR RPLTVHSQID DGDAYAHEDD
     3541 SERAWVRHAS GVLTVATGGP VDGSLTAWPP VGAEPVDVDG FYDRLAGMAL DYGPVFQGLR
     3601 AAWRSGDDFF AEVELPGAER TDAGAYGLHP ALFDAALHTV WLGAVEPEAG TGNGLLPFAW
     3661 SGVRLAAAGA SDLRVKVSRA GTGTSTVSLV LADGTGGPVA EVDSLTLRPV PADQLRAGSG
     3721 SDDAVFGLKW TPVSLPSAPD GMRIETYEDL AALRATDPPA DTEADAAAAA DAVVVPCPTG
     3781 TGADLATRVR EVTHAVLELV QWWLAEERPG RLVLVTRGGD LAQSAVCGLV RSAQTENPDR
     3841 IVLVETSSDA HAGAGSGVDD ADLARVLPGL IASGEPQAAV HADDEVRVPR LVRVAVPDAE
     3901 PELPGLGSGT VLLTGASGGL GGLFARHLVA EHGVRSLLLV SRRGGDAPGA AELTADLTAQ
     3961 GADVTWAACD VADRAAVRAL LAGPGQSLSA IIHTAGVLDD GIIGSLTPER LDAVFRPKVD
     4021 AALNLHDLAG ELSGDLSAFV LFSSVAGTLG TPGQANYAAA NTFLDALAEH RRAAGQRATS
     4081 LAWGLWAQDS ESAMTGSLDH TDLTRIQRMG LAAIPSSDGL RLFDAALALD RAVVAPLRLD
     4141 LGGLQGTVPP VLRGLRGTVR GTARRTAQTA PKGSLGQRLA GLAEAEREQV VLDLVRTEVA
     4201 AVLGHAGAQS VGADDSFKDI GFDSLTAVEL RNRLNSAVGM RLPATLIFDY PNPLTLAHFL
     4261 TGEAAGGEAA TAVPTTLSTA TGTADEPIAI VGMACRYPGG VQSPEDLWQL VFSGRDAVSG
     4321 FPEGRGWDVE QLYDPNPDQW GTSYTREGGF LHDAADFDAE FFGISPREAL AMDPQQRLLL
     4381 ETSWEAFERA GIDPATVRGS RTGVFAGVMY HDYGGRVHTS PPGLEGYLVN GSAGSIASGR
     4441 VSYTFGLEGP AVTVDTACSS SLVALHLAAQ ALRSGECSMA LVGGVTVMAG PSVFVEFSRQ
     4501 RGLSADGRCK AFGAGADGTG WAEGVGMLLV ERLSDARRNG HKVLAVVRGT AVNQDGASNG
     4561 LTAPNGPSQQ RVIRQALANA GLSSDEVDAV EAHGTGTRLG DPIEAQALIA TYGQERSEDR
     4621 PLWLGSLKSN IGHSQAAAGV GGVIKMVMAM QHGVLPQTLH VDEPTPHVDW SAGAVQLLTE
     4681 AVEWPASDGP RRAAVSSFGV SGTNAHVIVE QAATSEVTAR GTAVAGPVPW VLSAKSDAAL
     4741 REQAGRLLSF LDAEGVGGAG VRPEDVAYSL ATSRAVLECR AAVVGEELGE FRQGLEGIVS
     4801 GAAPVGGAVG GRVGFLFSGQ GSQRIGMGRE LYAAYPVFAA AYDEVCALLD ATVDVDAETL
     4861 HQTGSTQPAL FAVEVALFRL LESWGIRPDY VAGHSVGEIA AAHVAGVLSL EDAAKLVSAR
     4921 AALMQALPAG GAMVAIQATE AEVLPHLTHG VGLAAINGPR SVVLSGSEDA VLDIAEVFAQ
     4981 QGRKTSRLKV SHAFHSPLMD PMLEEFAEVV RGLTFSEPRI PVVSNLTGRL AEVYIPEYWV
     5041 RHVREAVRFA DGLHTLHELG VTMFVEIGPG GVLSALVQGC LDDGTHIVTV PALRADRPEP
     5101 YALVTAVGQL HTHGISPEWQ ALFPGARRVD LPTYAFQRER YWLDAPQASG DVRAAGLGAA
     5161 DHPLLGAAIA TADSDGAVLT GLLSLGTHPW LADHAVNGIV LLPGTAFVEL AIRAGDETGC
     5221 GWIEDLTLEL PLVVPERGGV TLQVAVGPED ESGRRQLSVH SRVDDRSWLR HATGVLSSAE
     5281 APSAAKLGAW PPAGAEAVDL TAFYEGMAAA GLDYGPVFQG LRSVWRDGDD VFAEVELPDE
     5341 SAAEAAAFAL HPALLDAALH ALAAGGLVSL DDSPALPFAW SGVVVQAAGA AMVRVKLSRT
     5401 ATGSVTLAVA DGAGDPVASV ESLSLRAASA EQLPGAVGGD QLFGLEWTRF TLPSATDALM
     5461 IETVADFDAL RESEGTPDVV VVPCPAGSGR ETADRVHSTT SEVLALVQWW LAEERAGRLA
     5521 LVTRPGDLAH AAVWGLVRSA QSENPDRIVL VEAEETDEAV RVLPAALASG EPQFAVRDGE
     5581 VFVPRLVKAT RSATGTATGT PDFGVGPVLL TGASGALGGL VARHLVAEHG VRSLLLLSRR
     5641 GAEAPGAVEL EAELAAWGAE VRWAACDAAD RDALAEVLAG TPVTAVVHAA GVLDDGVIAA
     5701 LTPERMEKVL RPKTDAVLNL HELTSDLSAF VVFSSVSGIL GSAGQGNYAA ANAFLDAFAE
     5761 ARRARGLPAT SLAWGLWEQG SGMADRLDQA DLARLKRVGL APIAVDEGLR LFDAALALDR
     5821 AVVAPLRLDL GGLQGTVPPV LRGLRGTVRG TARRMAQTAP KGSLGQRLAG LPQAEREQVV
     5881 LDLVRAEVAA VLGHASAQAV QPEHAFQDAG FDSLTSVELR NRLNAATGLR LPVTMVFDHP
     5941 TPVALSRFLL AETLGVQEQA EAAIAAVTGT DEAIAIVGMA CRFPGDVRSP EDLWRLVASG
     6001 GDAISGFPED RGWDVENLYD PDPDRSGKSY VRHGGFLHEA AEFDPAFFGI SPREALAMDP
     6061 QQRLLLETSW EAFERAGIDP ATVRGSRTGV FAGVMYHDYG GRVKTAPEGM DAYLGSGSAG
     6121 SIASGRVSYT FGLEGPAVTV DTACSSSLVA LHLATQALRS GECSMALVGG VTVMATPSTF
     6181 VEFSRQRGLS ADGRCKAFAA GADGTGWAEG AGMLLVERLS DARRNGHTVL AVVRGTAVNQ
     6241 DGASNGLTAP NGPSQQRVIR QALANAGVSS EQVDAVEAHG TGTKLGDPIE AQALIATYGQ
     6301 ERPGDRPLWL GSLKSNIGHA QAAAGVGGVI KMVMAMRHGA LPRTLHVDEP TPHVDWSAGD
     6361 VRLLTEAMEW PETDHPRRAA VSSFGISGTN AHVIVEQAPD TAELPPVPDS GKAVPWVLSG
     6421 RTEAALRAQA ERLLSLVPEM DLPPADIGFS LATTRSAMEH RAAVVGESRD ELLEGLRALA
     6481 AGSPSTRVVL GEPGAGGKSG FLFSGQGSQR IGMGRELYDA FPVFAAAYDE VCALVDAPVD
     6541 VDSEELNQTG TTQPALFAVE VALFRLLESW GIRPDYVAGH SVGEIAAAHV AGVLSLEDAA
     6601 KLVSARAALM QALPADGAMV AVQATEDEVL PHLTDGVGIA AVNGPQSVVV SGAEDVVVAI
     6661 GEAFRERGRK TSRLKVSHAF HSPLMDPMLE EFAEAVSGLS FNEPRLPVVS NLTGRLAEPY
     6721 TPEYWVRHVR EAVRFADGLH TLHELGVTTF VEIGPGGVLS ALAQGCLDGD IVTVPAVRTD
     6781 RPEPQAVVTA LAELHAHGVS PDWRALFPGA RRVDLPTYPF QYERLWLEAP EEYTGTAAAT
     6841 GLGLGAAEHP LAGAAVALPG AGGFLVTGRL SLRTHPWLAD HTVMDSVLLP GTALVELAVR
     6901 AGEEAGCAQV EDLTLEAPLI VPERGGVAVQ VWVEAEEEPG RCALSVHSRR EDAPDDAPWV
     6961 RHAVGRLTDA LPEPPHGADL GAWPPAGAEA VDLTGFYEGL DGLGLGYGPV FRGLRSVWRS
     7021 GDDVLAEVAL PEGTEAGAFA VHPALLDAAL HAVGAGGLVP VLDGPLLPFA WSEVGVRAAG
     7081 ATALRVKLSR TGTDAVSLTV ADASGGLVAT VGSLSLRPVS REQLLAAGGS GRRADDSLFG
     7141 LAWQPAVLTE TDAAAGLDVR SYADLAALST EPALPDVAVV TVVPCPAGSG RETADRVHST
     7201 TSEVLALVQW WLAEERAGRL ALVTRPGDLA HAAVWGLVRS AQSENPDRIV LVEAEETDEA
     7261 VRVLPAALAS GEPQFAVRDG EVFVPRLVKA TRSATGTATG TPDFGVGPVL LTGASGALGG
     7321 LVARHLVAEH GVRSLLLLSR RGAEAPGAVE LEAELAAWGA EVRWAACDVA DREAVSGMLN
     7381 GLGEQSLSAV VHTAGVLGDG IVASLTPERM REVFRPKVDA VLNLHECTRD MGLAAFVVFS
     7441 SVAGMVGSAG QASYAAANSF LDAFSAHRRR EGLPAISLAW GVWEQSGAMT DGLVEADRAR
     7501 MARSGVLPLP PEEGLRLFDA ALASDEAVLA PVRIDTGALR AGEAPPVLRA LVPAAAARRT
     7561 ARAAAAPSAS SLAERLEEMP EAEREKTVLD LVRAEVAAGL GHASDRTVRP EHAFQDLGFD
     7621 SLTAVELRNR LNKATGLRLP ATLVFDHPTP ALLARHVFMA AAGAAEPALV DSLLADLDRV
     7681 EQELVTTLAA SEARDRILSK LQGLLAIAGE FGKAPAQEGP GTGGSDLESA TDDEVFDLLG
     7741 KEFGIS
//