LOCUS BAC68128.1 3564 aa PRT BCT 07-OCT-2016
DEFINITION Streptomyces avermitilis MA-4680 = NBRC 14893 modular
polyketide synthase protein.
ACCESSION BA000030-422
PROTEIN_ID BAC68128.1
SOURCE Streptomyces avermitilis MA-4680 = NBRC 14893
ORGANISM Streptomyces avermitilis MA-4680 = NBRC 14893
Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
Streptomycetaceae; Streptomyces.
REFERENCE 1 (bases 1 to 9025608)
AUTHORS Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M.
TITLE Direct Submission
JOURNAL Submitted (29-MAR-2002) to the DDBJ/EMBL/GenBank databases.
Contact:S Omura
Kitasato University, Kitasato Institute for Life Sciences; 1-15-1
Kitasato, Sagamihara, Kanagawa 228-8555, Japan
URL :http://avermitilis.ls.kitasato-u.ac.jp/
REFERENCE 2
AUTHORS Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H.,
Shiba,T., Sakaki,Y., Hattori,M. and Omura,S.
TITLE Complete Genome Sequence and Comparative Analysis of the
Industrial Microorganism Streptomyces avermitilis
JOURNAL Nat. Biotechnol. 21, 526-531 (2003)
REFERENCE 3
AUTHORS Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M.
TITLE Genome sequence of an industrial microorganism Streptomyces
avermitilis: Deducing the ability of producing secondary
metabolites
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 98, 12215-12220 (2001)
REFERENCE 4
AUTHORS Ikeda,H., Shin-ya,K. and Omura,S.
TITLE Genome mining of the Streptomyces avermitilis genome and
development of genome-minimized hosts for heterologous expression
of biosynthetic gene clusters
JOURNAL J. Ind. Microbiol. Biotechnol. 41, 233-250 (2014)
COMMENT This work was done in collaboration with Haruo Ikeda(*1),
Jun Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3),
Mayumi Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4),
Tomomi Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4),
Tadayoshi Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira
Hattori(*1,*7)
and Satoshi Omura(*1,*3).
Final finishing process and all annotation were done by H. Ikeda
and J. Ishikawa.
*1 Kitasato Institute for Life Sciences, Kitasato University
*2 National Institute of Infectious Diseases
*3 The Kitasato Institute
*4 National Institute of Technology and Evaluation
*5 School of Science, Kitasato University
*6 Institute of Medical Science, University of Tokyo
*7 RIKEN, Genomic Sciences Center
All the annotated genes identified are available from following
urls.
http://avermitilis.ls.kitasato-u.ac.jp
FEATURES Qualifiers
source /db_xref="taxon:227882"
/mol_type="genomic DNA"
/note="This strain is also named as strain: ATCC 31267,
NCIMB 12804 or NRRL 8165."
/organism="Streptomyces avermitilis MA-4680 = NBRC 14893"
/strain="MA-4680"
protein /gene="pteA2"
/locus_tag="SAVERM_418"
/old_locus_tag="SAV_418"
/transl_table=11
BEGIN
1 MANEDKLRHF LKRVTADLQE TRRRLRDYED AAGEPVAIIG MSCRYPGGVD SPEDLWELVA
61 GGRDAVSEFP ADRGWDLDAL YDPDPESRGT SYAREGAFLR DLARFDAGLF GISPREALAM
121 DPQQRLLLET SWELFERAGI DAASLAGSRT GVFAGVMNHE FLAALQNSPQ DLEGYLGTGT
181 SGSVASGRVA YTFGLEGPAV TVDTACSSSL VALHLAVQSL RNGECSLAVA GGVTAMVGPA
241 TFVGFSRQRG LAPDGRCKPF AAGADGTGWG EGAGLLLVER LSDARRNGHE VLAVVRGSAV
301 NQDGASNGLT APNGPSQQRV IRQALAAAQL TTAQVDAVEA HGTGTRLGDP IEAQALLATY
361 GQGRPDDKPL WLGSIKSNIG HTQAAAGVAG IIKMVMAMRH GELPRTLHVD APSVHVDWTA
421 GAVRLLTERT PWSASDQPRR AGISSFGISG TNAHTIIEEA PSAEAFAQDT GAPEGPEEGA
481 ESAEPVASEA ARPAAGGPVP WVISGRTEEA LRAQAERLLS RTDAEVPPLD VAFSLATTRT
541 ALEHRAVLQG ETPAELAEGL RAVASGSPAR GVARGLSGTG GRVGFLFSGQ GSQRLGMGRE
601 LYASYPAFAA AYDEVCAQLD AVVDVDSEEL HRTGAAQPAL FAVEVALFRL LESWGIRADY
661 VAGHSVGELA AAHVAGVLSL DDAAKLVSAR ARLMQALPAG GAMVAVQATE DEVLPHLTDA
721 VGIAAINGPR SVVVSGAEDA VTAIAEAFRQ QGRKSSRLKV SHAFHSPLMD PILEEFAEVV
781 RSLTFHRPQI PVVSNLTGRL AEPYTPQYWV RHVREAVRFA DGVRTLNDLG VTTFVEIGPG
841 GVLSALAEGC LDDDVVTVPA LRADRPERVA LVAAVSELHA HGVSPDWHAF FPGARRVDLP
901 TYAFQYERYW LDASPAAPGG VRAAGLGSAD HPLLGAAVSL AGGDERLLTG RLSLRTHPWL
961 SDHAVLGTAL LPGTAFVELA VRAADEAGCA LLEDLTLEAP LVVPEQGGVA VQVWVGAVDG
1021 TGRRPLTVHS RPEDDSDLPW VRHATGFVTE GSEEAGAAAA DRTLTAWPPT GSEPVDLDGF
1081 YDRLAALGLA YGPAFRGLRS AWRTGEDVFA EVALPDGTDT GSFLLHPALL DAALHAIGAG
1141 GADGSLVAEA DGPLLPFAWS RVSVRATGAS TLRVRLAPAG TDAVSLLVAD GAGEPVASVE
1201 SLTLRAVSAE RLRKRSGDAM FTVERAPLTL PSDDADGTAV AYVPDLAALA EADGPSQPDV
1261 VVVPCPDGPE GATEAERVRA VSTDVLRLVQ RWFAEDRTPR LVLMARCDDL AHAAAGGLVR
1321 SAQAENPGRI VLLETDRPDE AAALVPGVVL SGEPHVVVRE GEVSAPRLAR AASLATEDAV
1381 TGRADEAASA LVEGAASRLG TVLLTGAAGA LGKTLARHLV TGHGVRRLLL VSRRGADAPG
1441 AADLKAELAA LGAEATWAAC DLAERDALAR LLAATPVDSV VHTAGVLDDG VIAALTPERV
1501 GAVLAPKADA VLNLDELTGP STTFVLFSSA AGVFGNPGQG NYAAANAFLD AFARHRHAQG
1561 RPTVSLAWGL WEQEGAMADA LDEAGRSRMA RSGVLPLPTE DGLRLFDAAL ASNEPVLVPV
1621 RLDTAALRNR AAETVPALLR GLVRVSLRGT AQRAAAGSLA ERLAGLAADE RDEALLELVR
1681 GEVAAVLGHS SSRAVQPTYA FQDLGFDSLT AVELRNRLAT ATGLRLPATL VFDHPTPAAL
1741 ARHIGTELLG EAPAVTARAA ARQTATAADE PIAIVGMSCR LPGGVRSPED LWRLVASGRD
1801 GITRFPDNRG WDVDGLYDPD PERLGKTYAR DGGFLHEAAE FDAGFFGISP REALAMDPQQ
1861 RLLLEASWEA FERAGIDPAT IRGSRTGVFT GLMYHDYGQG PRQLPEGVEG LLTTGGSGSV
1921 ASGRVSYTFG LEGPAVTIDT ACSSSLVALH LAVQSLRNGE CTMALAGGVT VMAGPTVFVE
1981 FSRQRGLSPD GRCKAFAAGA DGTGWGEGVG LLLVERLSDA ERNGHRVLAV VRGSAVNQDG
2041 ASNGLTAPNG PAQQRVIRQA LASAGLKPAD VDAVEAHGTG TTLGDPIEAQ ALLATYGQER
2101 PAGQPLWLGS LKSNIGHTQA AAGVAGVIKM VMAMRHGVLP QTLHVDEPTP HVDWSAGDVR
2161 LLTEAVAWPD SDRPRRAAVS SFGVSGTNAH TIIEQAPTTE ELPLTSDSGA AVPWVLSGRT
2221 EAALQAQAAG LVSFLDDHDG DNDRDDVGEA AFAADVAYSL ATTRAAFEHR AVVVGQTLQE
2281 LRQGLAGVAG GATPPGVVTG TAHTGGKTVF VFPGQGSQWV GMAAKLLETS PVFRDRIDAC
2341 ERALAPHVDW SLTAVLRGTS EVEQDRVDVL QPVLWAMTVA LAEVWRSFGV TPDAVVGHSQ
2401 GEVSAAVIAG AISLEDGARV VVRRSLAVRE LQGRGAMASV TLPDEKAREL VGRWTGRLGI
2461 AAVNGPATVV VSGDTDALDE FLAHCQQDAI QARRVAVDYA AHSPQIERVE AQASEGFAGI
2521 SPLPGSVPFY STVTGGKLAA DELGSGYWYR NMRQTVRFHD AIRAALADGH DVFVEVSPHP
2581 VQLAGIQDAI EAADADAAVV PTLRRRDGGR NRLMLALAQA LVHGVAIDWD AVLPGARRVD
2641 LPTYAFQHER YWLEAGAPAG DVRAAGLDAA DHPFLGAAVE LPDAGGHLLT GLLSLQAQPW
2701 LADHAVLGTV LLPGTAFVEL AAHAAAETGC DLVEELTLQA PLVLPEHGGV ALQVLVGAQD
2761 DSGRRPLSVH SRAGDDGPWI RNATGVLAAG GAPSGTDLSN WPPADARPVD LDGFYDRMAD
2821 LGLSYGPLFQ GLRAAWRGHD AVYAELAVPD LAQTDAFGVH PALLDSALHA LGAGGLVPAA
2881 DGPLLPFAWS RVTVHGTGAA GLRVRLSQVG GDAVRLEAAD GTGRPVVSVE SLTLRPVSVE
2941 QLRPSSRDSL FTVQWAPLAA TADARTPVVQ AYDGIAALLA APTVETGAQA DTDAVVVPCP
3001 GGSGTDVERV RSVLAEVLWL VQWWQAEDRA ARLVLVTRGA VAAGDESAQG DPVQAAVWGL
3061 VRSAQSENPD RIVLLDTEQN ADVEQVAATV VPRLVASEEP QAALRGDALL LPRLARAAAD
3121 APRATPDFGT GRVLLTGASG ALGGLVARHL VAEHGLRSLL LMSRRGADAE GAAELQEELT
3181 AAGAEVLWAA CDVADRDALA EVLSGTPVTA VVHTAGVLDD GVIGSLTPER MEMVLRPKVD
3241 AVLNLHELAG DVSAFVLFSS LAGTLGTPGQ ANYAAANAFL DAFARRRRAQ GLPAVSLPWG
3301 LWQRTGTMTE DLGGADRTRL ARGGVLPLSD EDGLELLDAA LALQEPLVVA ARLDLAALRN
3361 ATAPVPPLLR ALVGGRLRRT DRAAAVPLAQ RIAGLPESER EEAVLDLVRS EVAAVLGHSS
3421 AKTVQPDQAF GDLGFDSLTA VELRNRMNQA TGLRLPATLV FDHPTPAVLA QRVLKDLPGG
3481 TAGTAPVFDE LDRLGAALDG AGADGIDNIT RTKINMRLQA LLARWNGNEP ADPGGAGGAE
3541 DEDDLSSASD EELYELLDDE LGIS
//