LOCUS BAC68125.1 3352 aa PRT BCT 07-OCT-2016
DEFINITION Streptomyces avermitilis MA-4680 = NBRC 14893 modular
polyketide synthase protein.
ACCESSION BA000030-419
PROTEIN_ID BAC68125.1
SOURCE Streptomyces avermitilis MA-4680 = NBRC 14893
ORGANISM Streptomyces avermitilis MA-4680 = NBRC 14893
Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
Streptomycetaceae; Streptomyces.
REFERENCE 1 (bases 1 to 9025608)
AUTHORS Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
Kushida,N., Shiba,T., Sakaki,Y. and Hattori,M.
TITLE Direct Submission
JOURNAL Submitted (29-MAR-2002) to the DDBJ/EMBL/GenBank databases.
Contact:S Omura
Kitasato University, Kitasato Institute for Life Sciences; 1-15-1
Kitasato, Sagamihara, Kanagawa 228-8555, Japan
URL :http://avermitilis.ls.kitasato-u.ac.jp/
REFERENCE 2
AUTHORS Ikeda,H., Ishikawa,J., Hanamoto,A., Shinose,M., Kikuchi,H.,
Shiba,T., Sakaki,Y., Hattori,M. and Omura,S.
TITLE Complete Genome Sequence and Comparative Analysis of the
Industrial Microorganism Streptomyces avermitilis
JOURNAL Nat. Biotechnol. 21, 526-531 (2003)
REFERENCE 3
AUTHORS Omura,S., Ikeda,H., Ishikawa,J., Hanamoto,A., Takahashi,C.,
Shinose,M., Takahashi,Y., Horikawa,H., Nakazawa,H., Osonoe,T.,
Kikuchi,H., Shiba,T., Sakaki,Y. and Hattori,M.
TITLE Genome sequence of an industrial microorganism Streptomyces
avermitilis: Deducing the ability of producing secondary
metabolites
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 98, 12215-12220 (2001)
REFERENCE 4
AUTHORS Ikeda,H., Shin-ya,K. and Omura,S.
TITLE Genome mining of the Streptomyces avermitilis genome and
development of genome-minimized hosts for heterologous expression
of biosynthetic gene clusters
JOURNAL J. Ind. Microbiol. Biotechnol. 41, 233-250 (2014)
COMMENT This work was done in collaboration with Haruo Ikeda(*1),
Jun Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3),
Mayumi Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4),
Tomomi Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4),
Tadayoshi Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira
Hattori(*1,*7)
and Satoshi Omura(*1,*3).
Final finishing process and all annotation were done by H. Ikeda
and J. Ishikawa.
*1 Kitasato Institute for Life Sciences, Kitasato University
*2 National Institute of Infectious Diseases
*3 The Kitasato Institute
*4 National Institute of Technology and Evaluation
*5 School of Science, Kitasato University
*6 Institute of Medical Science, University of Tokyo
*7 RIKEN, Genomic Sciences Center
All the annotated genes identified are available from following
urls.
http://avermitilis.ls.kitasato-u.ac.jp
FEATURES Qualifiers
source /db_xref="taxon:227882"
/mol_type="genomic DNA"
/note="This strain is also named as strain: ATCC 31267,
NCIMB 12804 or NRRL 8165."
/organism="Streptomyces avermitilis MA-4680 = NBRC 14893"
/strain="MA-4680"
protein /gene="pteA5"
/locus_tag="SAVERM_415"
/old_locus_tag="SAV_415"
/transl_table=11
BEGIN
1 MSSKEDRLLE YLKRVTGDLR QVRERLREVE EKDDDPIAIV GMACRYPGGV RSPEDLWHLV
61 AAGGDAVGDF PADRGWDVEG IYDPDPDARG KTYARRGGFL YEAGEFDPGF FGISPREAVA
121 MDPQQRLLLE TTWETFERAG IDAESVRGSR TGVFVGSGYQ DYVNLLVGVG GESDGHLGTG
181 NSASVMSGRI AYTFGLEGPA VTVDTACSSS LVALHWAIQA LRNGECSMAL AGGVQVMTTP
241 TAFVEFSRQR GLAPDGRCKA FGAGADGTGW AEGVGMLLVE RLSDAVRNGH EVLAVVRGSA
301 VNQDGASNGL TAPNGPAQQR VIRQALASAG LSPAQIDVVE AHGTGTTLGD PIEAQALLAT
361 YGRERTEDRP LWLGSLKSNI GHSQAAAGVG GIIKMVMAMR HGVLPQTLHV DEPTPHVDWS
421 AGAVRLLTEA VEWPETHHPR RAAVSSFGVS GTNAHTIIEQ APPAQDEGPA GALVDGPLAW
481 VLSARSDAAL RAQAARLRPS ARGEVRPQDI GLSLATTRAA MRHRAAVVGD NREELLSGLE
541 DLATGTPSSR VLLGRPAGGK TGFLFSGQGS QRIGMGRELY AAYPVFAAAY DEVCAHLDAP
601 VDVDAETLHR TGGTQPALFA VEVALFRLLE SLGVRPDFVV GHSVGEIAAA HVAGALSLDD
661 AAKLVSARAA LMQALPAGGA MVAVQATEEE VLPHLTDGVS IAAVNGPSSV VVSGDETAAL
721 AIAAGFAEQG RKTSRLKVSH AFHSPLMDPM LAEFAEVVRG LAFEQPQLPV VSNLTGQPVE
781 AYTPEYWVRH VRETVRFADS VRTLHDLGVK TFIEIGPGGV LSGMAQGCAD DIVTVPVLRA
841 DRPERQAVVT ALAHLHTHGV SVDWHSFFAG ARRTDLPTYA FQREWYWVDA PESAAAEADP
901 VDAEFWETVE RGDLQALAET LDIGAGDTFG DVLPRLSSWR RQRKEQSTVD DRRYRESWKR
961 LGELGPAGIG GTWLLAVPAE ENEQTAAVRT ALTARGATLK TLVVDAASHR AGLAGELAGI
1021 GPVDGVLSLL VNGDPVLPTL LLVQALGDAG VDAPLWCLTS GAVAVSGSDA VRDARHAQVW
1081 GLGRTVALEL PRRWGGLIDL PESVDDQAAV RLADVLEQAL TGRWEEDQLA VRASGVFARR
1141 LAHAPARAAT RRWQPRGTVL ITGGTGALGG HVARWLARGG AEHLVLTSRR GADAPGAAAL
1201 RDELEVLGAR VTFAACDVAD RDAVAALLAQ HVFTAVVHAA GVADAGTVDA TTPAAFAAAL
1261 AAKVGGAAHL DELLGDQELD AFVLFSSISG VWGSGGQAAY AAGNAFLDGL ARQRRDRGLT
1321 ATAVSWGPWA DGGMVADGDD EERLRRRGLR AMTPASAITS LQRALDRDET LLTVADVDWS
1381 RFIVPFTLGR PSPLLGDLPE VRAALAVDTP AAGHGSGALA ESLAALSHQD RARALVDLVR
1441 THAAAVLGHR GAGAVEADRP FRDIGFDSLT AVELRNRINK ATGLSLPATL IFDHPTAADL
1501 AAHLLAELTG GQHEAVAAAA TAAVLDEPIA IIGMACRYPG GVRSPEDLWE LVASGRDAIS
1561 RFPGNRGWDV EALYHPDPDH PGTTYTTQGG FLHDADEFDP AVFGISPREA VAMDPQQRLL
1621 LDTTWEAFER ARIAPHAMRS TTTGVFVGSG YQDYTGRPLK VPDGVEGYIP SGNAASVISG
1681 RLSYTFGLQG PSVTVDTACS SSLTALHLAM QALRGGECSM ALAGGVMVMA GPSAFTMSSR
1741 QRALSADGRC KAFSSSADGT GFAEGVGLVL LERLSDARRN GHEVLAVVRG SAVNQDGASN
1801 GLTAPSGKAQ QQVIRQALAN ARLAPDEVDA VEAHGTGTRL GDPIEAQALL ATYGKERSEG
1861 RPLWLGSLKS NIGHTQAAAG VGGVIKMVMA IRNGILPQTL HVDEPTPHVD WAGGNVRLLT
1921 EQTAWPDQDR PRRAAVSSFG MSGTNVHTII EQAPQTATAA EVEQPPAAQD ATAAQPLDVF
1981 PWALSAKTDR SLREQARRLL NHLDRTEGLT LPDVGRALVT TRTQLEQRAV VVGQDRHELR
2041 AGLAALADGK PADTVVQGTA SASGKVAFVF PGHGSQWTEM ARELLDTSPV FAEQAKACAE
2101 AFAPYLDWPL LDVLRAEPDA PDVADVEVAQ PALFTVMVSL AALWRSYGVT PAAVVGHSQG
2161 EVAAAYVAGA LTLDDAARIV ALRSRSLTKL IGKGAMLAIA MPAERVRARL EKYGDRLSVA
2221 AVNGPAALTV SGEPDAVDEL LAELEAEGVR VRKVRGATGA GHSTQVESLR PELLHLLAPV
2281 APGAAEVPYY STVTGTVLDT TTLDAEYWYR NARHTVEFEW TVRTLLADGH GVFVECSPHP
2341 LLADAVQEIA EETGADAVTG SSLRRGQGGM DRFLRSVSEL HVSGVHVDLT APFAGRPVRR
2401 VDLPTYAFQP QRYWLESADP VPAGTDPVEA GFWELVENTD LSGLADELGA DDAALVGPAL
2461 PVLSAWRRRS REKSTVDGWR YRVSFRRLTD HAAPGLNGLW LAVLPAGLAD EQWAPCVVGV
2521 LAAHGAKVRV VELPVDCDRS QAAKRLAEEL RGEQPAGVLS MLGLAPGCHP AHPTLSASLA
2581 TTVTLLQALG DVDVQAPLWC ATRGAVSTGV TDPLRDAGQA QLWGLGVVAA LELPRRWGGL
2641 VDLPEELDEH ALRRLAGVLA QHDEDQLAVR VDGVYGRRMV RARPADEESA TPWKPRGTVL
2701 ITGGTGGVGR HLARWLAGAG AQHLVLTSRS GPDAPGAQEL HAELTALGAE VTIAACDMAD
2761 RAAVARLLAG IESRHPLTAV LHAAGTARSS MLADAGLDEF AEAAASKVTG AIHLDELLDG
2821 RELDAFVLFA SGAGVWGSGG QASYASANAF LDALALRRRA RGLTATSVAW GGWAGGGMVD
2881 DAVQERGERR GLGVMAPELA ISALREAVEH DEAALTVAPI DWEKFLPAFT VGRPSPLLAD
2941 LPDVQRLLEA EQAVGEGTSA GAALATELAA LAPVEQEERL LEHVRAQSAV VLGHASAEDV
3001 LPTAHFLELG FDSLTAIDLR RRLSAATGLR LPSGLAFDHP TPARLAKHLL TRLQSTGSAA
3061 AEERPADMLV QLYRHASENG TAAEAMGMLM EAARFRPSFE RPEELDRRPA PVRLSQGDHP
3121 LALMCFSPYV VPAGAHQYAR FAAPFRDRLD VWALVHPGYE KGEPVPSDPD VVFRLHAQTV
3181 RECAGGKPAV LLGYSSGGWI AHGVAAHLEA MGERPAAVVM VDSFSREVPF DHQVLNAMAQ
3241 AHSQRLDFMR SGGEQLTAMG RYMRLFDDWA APQIAAPTLL VRASEPMLAG AGDGDGRAAP
3301 PEHVDTIVEV TGNHYSMLED HAGTTAAAVD SWLADAVTDA SGPVAPADAT TA
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