LOCUS       APA94455.1               414 aa    PRT              BCT 30-JAN-2018
DEFINITION  Nocardia seriolae ATP-dependent helicase HRQ1 protein.
ACCESSION   CP017839-364
PROTEIN_ID  APA94455.1
SOURCE      Nocardia seriolae
  ORGANISM  Nocardia seriolae
            Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae;
            Nocardia.
REFERENCE   1  (bases 1 to 8304518)
  AUTHORS   Han,H.-J.
  TITLE     Genome sequence of Nocardia seriolae strain EM150506, isolated from
            Anguila japonica
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8304518)
  AUTHORS   Han,H.-J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-OCT-2016) Pathology Research Division, National
            Institute of Fisheries Science, #216, Gijanghaean-ro, Gijang-eup,
            Gijang-gun, Busan 46083, South Korea
COMMENT     DNA/bacteria available from National Institute of Fisheries Science
            (NIFS) in South Korea.
            
            ##Genome-Assembly-Data-START##
            Assembly Method       :: SMRT analysis v. 2.3.0
            Genome Coverage       :: 156x
            Sequencing Technology :: PacBio
            ##Genome-Assembly-Data-END##
FEATURES             Qualifiers
     source          /organism="Nocardia seriolae"
                     /mol_type="genomic DNA"
                     /strain="EM150506"
                     /host="Anguilla japonica"
                     /db_xref="taxon:37332"
                     /country="South Korea"
                     /collection_date="2015-05-06"
     protein         /locus_tag="NS506_00372"
                     /function="ATP-binding; DNA damage; DNA repair;
                     DNA-binding; Helicase; Hydrolase; Nucleotide-binding;
                     Nucleus; Stress response."
                     /note="Helicase with 3'-5' helicase activity involved in
                     genome stability (PubMed:23456718, PubMed:24440721,
                     PubMed:24700328). Functions in the RAD4-dependent
                     nucleotide excision repair (NER) pathway and plays a
                     critical role in DNA interstrand cross-link repair
                     (PubMed:24440721, PubMed:24682993). Unwinds relatively
                     long duplex DNA up to 120-bp and requires a long 3'-tail
                     of at least 70 nucleotides for efficient unwinding of
                     duplex DNA (PubMed:23026052). Activity is significantly
                     stimulated by a preexisting fork structure
                     (PubMed:24682993). Shows both processive helicase and DNA
                     strand annealing activities (PubMed:24682993). Affects
                     telomere length by a non-catalytic mechanism, probably
                     through inhibiting telomerase by competing with it for
                     ssDNA binding (PubMed:24440721); Belongs to the helicase
                     family. HRQ1 subfamily; Contains 1 helicase ATP-binding
                     domain; Contains 1 helicase C-terminal domain"
                     /transl_table=11
                     /db_xref="UniProtKB/Swiss-Prot:Q05549"
BEGIN
        1 MDIAGLDAVV VAGYPGTVAS FWQQAGRAGR RTQGSLVLLI ARDDPLDTYL VHHPEALLGR
       61 PLEASITDPH NPYVLGPHLL CAALEQPLSD AEVHGFQAWE LLSDLAEQGL IRRRAGVARD
      121 GTARWFVTAD AHPHDAVDVR GGIGTAVAVV DGESGRMLGT TDAGRAPATL HPGAVHLHQG
      181 ESYVVDELDL EEGVALVHAD TPGWSTSARA VTTLEIEEVG VERRFGSVTT AFAQVLVTRR
      241 VTGYLRRLPS GEVLDLVELD LPAQTLPTRA VYYTVTPELL ARAGIDARHA AGALHAAEHA
      301 AIGMLPLVAT CDRWDIGGVS MAEHADTGLP TVFVYDGHPG GAGFAERGFS RLRHWLQATL
      361 GAIRSCACAS GCPSCVQSPK CGNGNNPLDK AGAARLLRAI LAELGAGDDG NADP
//