LOCUS APA94455.1 414 aa PRT BCT 30-JAN-2018 DEFINITION Nocardia seriolae ATP-dependent helicase HRQ1 protein. ACCESSION CP017839-364 PROTEIN_ID APA94455.1 SOURCE Nocardia seriolae ORGANISM Nocardia seriolae Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Nocardia. REFERENCE 1 (bases 1 to 8304518) AUTHORS Han,H.-J. TITLE Genome sequence of Nocardia seriolae strain EM150506, isolated from Anguila japonica JOURNAL Unpublished REFERENCE 2 (bases 1 to 8304518) AUTHORS Han,H.-J. TITLE Direct Submission JOURNAL Submitted (21-OCT-2016) Pathology Research Division, National Institute of Fisheries Science, #216, Gijanghaean-ro, Gijang-eup, Gijang-gun, Busan 46083, South Korea COMMENT DNA/bacteria available from National Institute of Fisheries Science (NIFS) in South Korea. ##Genome-Assembly-Data-START## Assembly Method :: SMRT analysis v. 2.3.0 Genome Coverage :: 156x Sequencing Technology :: PacBio ##Genome-Assembly-Data-END## FEATURES Qualifiers source /organism="Nocardia seriolae" /mol_type="genomic DNA" /strain="EM150506" /host="Anguilla japonica" /db_xref="taxon:37332" /country="South Korea" /collection_date="2015-05-06" protein /locus_tag="NS506_00372" /function="ATP-binding; DNA damage; DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Stress response." /note="Helicase with 3'-5' helicase activity involved in genome stability (PubMed:23456718, PubMed:24440721, PubMed:24700328). Functions in the RAD4-dependent nucleotide excision repair (NER) pathway and plays a critical role in DNA interstrand cross-link repair (PubMed:24440721, PubMed:24682993). Unwinds relatively long duplex DNA up to 120-bp and requires a long 3'-tail of at least 70 nucleotides for efficient unwinding of duplex DNA (PubMed:23026052). Activity is significantly stimulated by a preexisting fork structure (PubMed:24682993). Shows both processive helicase and DNA strand annealing activities (PubMed:24682993). Affects telomere length by a non-catalytic mechanism, probably through inhibiting telomerase by competing with it for ssDNA binding (PubMed:24440721); Belongs to the helicase family. HRQ1 subfamily; Contains 1 helicase ATP-binding domain; Contains 1 helicase C-terminal domain" /transl_table=11 /db_xref="UniProtKB/Swiss-Prot:Q05549" BEGIN 1 MDIAGLDAVV VAGYPGTVAS FWQQAGRAGR RTQGSLVLLI ARDDPLDTYL VHHPEALLGR 61 PLEASITDPH NPYVLGPHLL CAALEQPLSD AEVHGFQAWE LLSDLAEQGL IRRRAGVARD 121 GTARWFVTAD AHPHDAVDVR GGIGTAVAVV DGESGRMLGT TDAGRAPATL HPGAVHLHQG 181 ESYVVDELDL EEGVALVHAD TPGWSTSARA VTTLEIEEVG VERRFGSVTT AFAQVLVTRR 241 VTGYLRRLPS GEVLDLVELD LPAQTLPTRA VYYTVTPELL ARAGIDARHA AGALHAAEHA 301 AIGMLPLVAT CDRWDIGGVS MAEHADTGLP TVFVYDGHPG GAGFAERGFS RLRHWLQATL 361 GAIRSCACAS GCPSCVQSPK CGNGNNPLDK AGAARLLRAI LAELGAGDDG NADP //