LOCUS       APA94452.1               959 aa    PRT              BCT 30-JAN-2018
DEFINITION  Nocardia seriolae DNA topoisomerase protein.
ACCESSION   CP017839-361
PROTEIN_ID  APA94452.1
SOURCE      Nocardia seriolae
  ORGANISM  Nocardia seriolae
            Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae;
            Nocardia.
REFERENCE   1  (bases 1 to 8304518)
  AUTHORS   Han,H.-J.
  TITLE     Genome sequence of Nocardia seriolae strain EM150506, isolated from
            Anguila japonica
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8304518)
  AUTHORS   Han,H.-J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-OCT-2016) Pathology Research Division, National
            Institute of Fisheries Science, #216, Gijanghaean-ro, Gijang-eup,
            Gijang-gun, Busan 46083, South Korea
COMMENT     DNA/bacteria available from National Institute of Fisheries Science
            (NIFS) in South Korea.
            
            ##Genome-Assembly-Data-START##
            Assembly Method       :: SMRT analysis v. 2.3.0
            Genome Coverage       :: 156x
            Sequencing Technology :: PacBio
            ##Genome-Assembly-Data-END##
FEATURES             Qualifiers
     source          /organism="Nocardia seriolae"
                     /mol_type="genomic DNA"
                     /strain="EM150506"
                     /host="Anguilla japonica"
                     /db_xref="taxon:37332"
                     /country="South Korea"
                     /collection_date="2015-05-06"
     protein         /gene="topA"
                     /locus_tag="NS506_00369"
                     /EC_number="5.99.1.2"
                     /function="DNA-binding; Isomerase; Magnesium;
                     Metal-binding; Topoisomerase."
                     /note="Releases the supercoiling and torsional tension of
                     DNA, which is introduced during the DNA replication and
                     transcription, by transiently cleaving and rejoining one
                     strand of the DNA duplex. Introduces a single-strand break
                     via transesterification at a target site in duplex DNA.
                     The scissile phosphodiester is attacked by the catalytic
                     tyrosine of the enzyme, resulting in the formation of a
                     DNA-(5'-phosphotyrosyl)-enzyme intermediate and the
                     expulsion of a 3'-OH DNA strand. The free DNA strand then
                     undergoes passage around the unbroken strand, thus
                     removing DNA supercoils. Finally, in the religation step,
                     the DNA 3'-OH attacks the covalent intermediate to expel
                     the active-site tyrosine and restore the DNA
                     phosphodiester backbone; Belongs to the type IA
                     topoisomerase family; Contains 1 Toprim domain; KEGG:
                     mei:Msip34_2877 DNA topoisomerase I"
                     /transl_table=11
                     /db_xref="UniProtKB/Swiss-Prot:O51768"
BEGIN
        1 MIVESPTKAK KIAPYLGRGY VVEASVGHIR DLPRGAADVP AKYKGQQWAR LGVDVDHDFE
       61 PIYVVSPEKK GKVSELKSLL ADADELYLAT DPDREGEAIA WHLLETLKPK VPVRRMVFHE
      121 ITESAIRAAA ADTRELDQDL VDAQETRRIL DRLYGYEVSP VLWKKVMPRL SAGRVQSVAT
      181 RVIVQRERER MAFRSAEYWD IAAKLDAGGN EEGGNPRVFG ARLVSVEGAR VATGRDFGSD
      241 GQLKSQGVVV LDAGYAQRLA ESLHGVDLTV TSVESKPYTR KPYAPFMTST LQQEAARKLR
      301 FTSERTMRVA QRLYENGYIT YMRTDSTTLS QSAINAARAQ ATQLYGAEYV SPTPRQYNRK
      361 VKNAQEAHEA IRPSGDVFAT PGQLHNKIDN DEFRLYELIW QRTVASQMQD ARGTTLTVRI
      421 TGVANSGEEC VFSASGRTIT FAGFLKAYVE SVDEEAGGQS DDAESRLPAL TEGQGVTAVE
      481 LAPDGHTTNP PARFTEASLI KALEDLGIGR PSTYSSIIKT ILDRGYVYKR GSALVPSWVA
      541 FAVIGLLEEH FGRLVDFDFT AAMEDDLDAI AGGREQRGNW LSSFYFGGDH GAQGSVARSG
      601 GLKKMVGERL DGIDAREVNS IKLFADDEGR DVVVRVGKFG PYLERMIANP DDPDGNPVSQ
      661 RANLPDDLPP DELTPEVAEK LFATPQEGRS LGTDPATGHE IVAKEGRFGP YVTEVLPEPA
      721 EDIDTGAKKT AKKAADKPKP RTGSLFKSMS VETVTLDEAL KLLSLPRVVG VDPASGDEIT
      781 AQNGRYGPYL KKGTDSRSLT GEDQIFSVTL EEALKIYAEP KRRGGQSASA PPLRELGVDP
      841 VSEKPMVIKD GRFGPYVTDG ETNASLRKGD EVESITDARA SELLADRRAR GPVKKAAKKT
      901 AKKAAAKKTA VAKTVVKKAA AKQAAAKTAD GVTTKKAAAA KKTPVKKAAA KKTAAAAKS
//