LOCUS       APA94292.1               369 aa    PRT              BCT 30-JAN-2018
DEFINITION  Nocardia seriolae Peptidase Do protein.
ACCESSION   CP017839-201
PROTEIN_ID  APA94292.1
SOURCE      Nocardia seriolae
  ORGANISM  Nocardia seriolae
            Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae;
            Nocardia.
REFERENCE   1  (bases 1 to 8304518)
  AUTHORS   Han,H.-J.
  TITLE     Genome sequence of Nocardia seriolae strain EM150506, isolated from
            Anguila japonica
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8304518)
  AUTHORS   Han,H.-J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-OCT-2016) Pathology Research Division, National
            Institute of Fisheries Science, #216, Gijanghaean-ro, Gijang-eup,
            Gijang-gun, Busan 46083, South Korea
COMMENT     DNA/bacteria available from National Institute of Fisheries Science
            (NIFS) in South Korea.
            
            ##Genome-Assembly-Data-START##
            Assembly Method       :: SMRT analysis v. 2.3.0
            Genome Coverage       :: 156x
            Sequencing Technology :: PacBio
            ##Genome-Assembly-Data-END##
FEATURES             Qualifiers
     source          /organism="Nocardia seriolae"
                     /mol_type="genomic DNA"
                     /strain="EM150506"
                     /host="Anguilla japonica"
                     /db_xref="taxon:37332"
                     /country="South Korea"
                     /collection_date="2015-05-06"
     protein         /gene="degP"
                     /locus_tag="NS506_00205"
                     /EC_number="3.4.21.107"
                     /function="Cell inner membrane; Cell membrane; Disulfide
                     bond; Hydrolase; Membrane; Protease; Repeat; Serine
                     protease; Signal; Stress response."
                     /note="DegP acts as a chaperone at low temperatures but
                     switches to a peptidase (heat shock protein) at higher
                     temperatures. It degrades transiently denatured and
                     unfolded proteins which accumulate in the periplasm
                     following heat shock or other stress conditions. DegP is
                     efficient with Val-Xaa and Ile- Xaa peptide bonds,
                     suggesting a preference for beta-branched side chain amino
                     acids. Only unfolded proteins devoid of disulfide bonds
                     appear capable of being cleaved, thereby preventing non-
                     specific proteolysis of folded proteins. Its proteolytic
                     activity is essential for the survival of cells at
                     elevated temperatures. It can degrade IciA, ada, casein,
                     globin and PapA. DegP shares specificity with DegQ. DegP
                     is also involved in the biogenesis of partially folded
                     outer-membrane proteins (OMP) (By similarity); Belongs to
                     the peptidase S1C family; Contains 2 PDZ (DHR) domains;
                     KEGG: eco:b0161 serine protease Do"
                     /transl_table=11
                     /db_xref="UniProtKB/Swiss-Prot:P0C0V1"
BEGIN
        1 MDDSRRRDSR RRGRGGRTLA LLIAAVVGFA GFLGYRGELP RWSFADDATA SSLVGPSLPP
       61 LDVDLVSKVA EPALVNITAG IRPYGLGAAG SGIVLSAEGE VLTSHHVIKG ADTVTVSDVG
      121 TGATYTATVA GYDSAADIAL LELAGADGLP VARIGSSAPL HLGDDVLAIG NAGGTGSPTA
      181 VGGPITNLDS TIVARNAADL SRKSLHGMIE VAAAVAAGQS GGALVDRYGA VIGVVTAASG
      241 DVAKAMGKGP NGYAVPIDTA MNVVRQIRSG TPTDTVHIGP TATLGILTSD AQPAGARIDV
      301 AVYGLPAYTA GLADGEIITA LDDRPVTTSQ MLKAALNAHK PDDVVRLGIS DPTGGHRTVS
      361 VTLTVGPPN
//