LOCUS APA94292.1 369 aa PRT BCT 30-JAN-2018 DEFINITION Nocardia seriolae Peptidase Do protein. ACCESSION CP017839-201 PROTEIN_ID APA94292.1 SOURCE Nocardia seriolae ORGANISM Nocardia seriolae Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Nocardia. REFERENCE 1 (bases 1 to 8304518) AUTHORS Han,H.-J. TITLE Genome sequence of Nocardia seriolae strain EM150506, isolated from Anguila japonica JOURNAL Unpublished REFERENCE 2 (bases 1 to 8304518) AUTHORS Han,H.-J. TITLE Direct Submission JOURNAL Submitted (21-OCT-2016) Pathology Research Division, National Institute of Fisheries Science, #216, Gijanghaean-ro, Gijang-eup, Gijang-gun, Busan 46083, South Korea COMMENT DNA/bacteria available from National Institute of Fisheries Science (NIFS) in South Korea. ##Genome-Assembly-Data-START## Assembly Method :: SMRT analysis v. 2.3.0 Genome Coverage :: 156x Sequencing Technology :: PacBio ##Genome-Assembly-Data-END## FEATURES Qualifiers source /organism="Nocardia seriolae" /mol_type="genomic DNA" /strain="EM150506" /host="Anguilla japonica" /db_xref="taxon:37332" /country="South Korea" /collection_date="2015-05-06" protein /gene="degP" /locus_tag="NS506_00205" /EC_number="3.4.21.107" /function="Cell inner membrane; Cell membrane; Disulfide bond; Hydrolase; Membrane; Protease; Repeat; Serine protease; Signal; Stress response." /note="DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures. It degrades transiently denatured and unfolded proteins which accumulate in the periplasm following heat shock or other stress conditions. DegP is efficient with Val-Xaa and Ile- Xaa peptide bonds, suggesting a preference for beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable of being cleaved, thereby preventing non- specific proteolysis of folded proteins. Its proteolytic activity is essential for the survival of cells at elevated temperatures. It can degrade IciA, ada, casein, globin and PapA. DegP shares specificity with DegQ. DegP is also involved in the biogenesis of partially folded outer-membrane proteins (OMP) (By similarity); Belongs to the peptidase S1C family; Contains 2 PDZ (DHR) domains; KEGG: eco:b0161 serine protease Do" /transl_table=11 /db_xref="UniProtKB/Swiss-Prot:P0C0V1" BEGIN 1 MDDSRRRDSR RRGRGGRTLA LLIAAVVGFA GFLGYRGELP RWSFADDATA SSLVGPSLPP 61 LDVDLVSKVA EPALVNITAG IRPYGLGAAG SGIVLSAEGE VLTSHHVIKG ADTVTVSDVG 121 TGATYTATVA GYDSAADIAL LELAGADGLP VARIGSSAPL HLGDDVLAIG NAGGTGSPTA 181 VGGPITNLDS TIVARNAADL SRKSLHGMIE VAAAVAAGQS GGALVDRYGA VIGVVTAASG 241 DVAKAMGKGP NGYAVPIDTA MNVVRQIRSG TPTDTVHIGP TATLGILTSD AQPAGARIDV 301 AVYGLPAYTA GLADGEIITA LDDRPVTTSQ MLKAALNAHK PDDVVRLGIS DPTGGHRTVS 361 VTLTVGPPN //