LOCUS       AJF01612.1               181 aa    PRT              BCT 20-JUN-2017
DEFINITION  Mycobacterium tuberculosis H37RvSiena Aminoglycoside 2'-
            N-acetyltransferase Aac (Aac(2')-IC) protein.
ACCESSION   CP007027-268
PROTEIN_ID  AJF01612.1
SOURCE      Mycobacterium tuberculosis H37RvSiena
  ORGANISM  Mycobacterium tuberculosis H37RvSiena
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1  (bases 1 to 4410911)
  AUTHORS   Santoro,F., Guerrini,V., Lazzeri,E., Iannelli,F. and Pozzi,G.
  TITLE     Genomic polymorphisms in a Laboratory Isolate of Mycobacterium
            tuberculosis Reference Strain H37Rv (ATCC27294)
  JOURNAL   New Microbiol. 40 (1), 62-69 (2017)
   PUBMED   27819398
REFERENCE   2  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-DEC-2013) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
REFERENCE   3  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-FEB-2015) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
  REMARK    Protein update by submitter
COMMENT     Annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (released 2013). Information about the Pipeline can be
            found here: http://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            
            Annotation modified by submitter.
            
            ##Assembly-Data-START##
            Assembly Method       :: Ray v. 2.3.1
            Coverage              :: 300
            Sequencing Technology :: Illumina
            ##Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Provider          :: NCBI
            Annotation Date              :: 12/30/2013 09:28:23
            Annotation Pipeline          :: NCBI Prokaryotic Genome Annotation
                                            Pipeline
            Annotation Method            :: Best-placed reference protein set;
                                            GeneMarkS+
            Annotation Software revision :: 2.3 (rev. 422554)
            Features Annotated           :: Gene; CDS; rRNA; tRNA; ncRNA;
                                            repeat_region
            Genes                        :: 4,146
            CDS                          :: 4,050
            Pseudo Genes                 :: 42
            CRISPR Arrays                :: 2
            rRNAs                        :: 3 (5S, 16S, 23S)
            tRNAs                        :: 45
            ncRNA                        :: 6
            Frameshifted Genes           :: 34
            ##Genome-Annotation-Data-END##
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis H37RvSiena"
                     /mol_type="genomic DNA"
                     /strain="H37RvSiena"
                     /db_xref="taxon:1437856"
     protein         /gene="aac"
                     /locus_tag="Y980_0262c"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /note="Rv0262c, (MTCY06A4.06c) Aac,aminoglycoside
                     2'-N-acetyltransferase (aac(2')-IC) (see citation below),
                     highly similar to NP_302635.1|NC_002677 aminoglycoside
                     2'-N-acetyltransferase from Mycobacterium leprae (182 aa);
                     Q49157|AAC2_MYCFO|AAC aminoglycoside
                     2'-N-acetyltransferase from Mycobacterium fortuitum (195
                     aa), Contains GNAT (Gcn5-related N-acetyltransferase)
                     domain. See Vetting et al. 2005. P94968|AAC2_MYCSM|AAC
                     aminoglycoside 2'-N-acetyltransferase from Mycobacterium
                     smegmatis (210 aa) (see also citation below). Also similar
                     to Q52424|AAC2_PROST aminoglycoside 2'-N-acetyltransferase
                     from Providencia stuartii (178 aa). Belongs to the
                     AAC(2')-I family of acetyltransferases. Note that
                     previously known as aac(2')-IC."
                     /transl_table=11
                     /db_xref="GOA:P0A5N0"
                     /db_xref="InterPro:IPR000182"
                     /db_xref="InterPro:IPR016181"
                     /db_xref="PDB:1M44"
                     /db_xref="PDB:1M4D"
                     /db_xref="PDB:1M4G"
                     /db_xref="PDB:1M4I"
                     /db_xref="UniProtKB/Swiss-Prot:P0A5N0"
BEGIN
        1 MHTQVHTARL VHTADLDSET RQDIRQMVTG AFAGDFTETD WEHTLGGMHA LIWHHGAIIA
       61 HAAVIQRRLI YRGNALRCGY VEGVAVRADW RGQRLVSALL DAVEQVMRGA YQLGALSSSA
      121 RARRLYASRG WLPWHGPTSV LAPTGPVRTP DDDGTVFVLP IDISLDTSAE LMCDWRAGDV
      181 W
//