LOCUS       AJF01583.1               511 aa    PRT              BCT 20-JUN-2017
DEFINITION  Mycobacterium tuberculosis H37RvSiena Succinate-semialdehyde
            dehydrogenase [NADP+] dependent (SSDH) GabD1 protein.
ACCESSION   CP007027-239
PROTEIN_ID  AJF01583.1
SOURCE      Mycobacterium tuberculosis H37RvSiena
  ORGANISM  Mycobacterium tuberculosis H37RvSiena
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1  (bases 1 to 4410911)
  AUTHORS   Santoro,F., Guerrini,V., Lazzeri,E., Iannelli,F. and Pozzi,G.
  TITLE     Genomic polymorphisms in a Laboratory Isolate of Mycobacterium
            tuberculosis Reference Strain H37Rv (ATCC27294)
  JOURNAL   New Microbiol. 40 (1), 62-69 (2017)
   PUBMED   27819398
REFERENCE   2  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-DEC-2013) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
REFERENCE   3  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-FEB-2015) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
  REMARK    Protein update by submitter
COMMENT     Annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (released 2013). Information about the Pipeline can be
            found here: http://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            
            Annotation modified by submitter.
            
            ##Assembly-Data-START##
            Assembly Method       :: Ray v. 2.3.1
            Coverage              :: 300
            Sequencing Technology :: Illumina
            ##Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Provider          :: NCBI
            Annotation Date              :: 12/30/2013 09:28:23
            Annotation Pipeline          :: NCBI Prokaryotic Genome Annotation
                                            Pipeline
            Annotation Method            :: Best-placed reference protein set;
                                            GeneMarkS+
            Annotation Software revision :: 2.3 (rev. 422554)
            Features Annotated           :: Gene; CDS; rRNA; tRNA; ncRNA;
                                            repeat_region
            Genes                        :: 4,146
            CDS                          :: 4,050
            Pseudo Genes                 :: 42
            CRISPR Arrays                :: 2
            rRNAs                        :: 3 (5S, 16S, 23S)
            tRNAs                        :: 45
            ncRNA                        :: 6
            Frameshifted Genes           :: 34
            ##Genome-Annotation-Data-END##
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis H37RvSiena"
                     /mol_type="genomic DNA"
                     /strain="H37RvSiena"
                     /db_xref="taxon:1437856"
     protein         /gene="gabD1"
                     /locus_tag="Y980_0234c"
                     /gene_synonym="gabD2"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /inference="protein motif:PROSITE:PS00070"
                     /note="Rv0234c, (MTCY08D5.30c)
                     gabD1,succinate-semialdehyde dehydrogenase [NADP+]
                     dependent,equivalent to AL022486|MLCB1883_6 probable
                     aldehyde dehydrogenase from Mycobacterium leprae (457 aa).
                     Also highly similar to Q55585|GABD|SLR0370 probable
                     succinate-semialdehyde dehydrogenase from Synechocystis
                     sp. strain PCC 6803 (454 aa); and similar to others e.g.
                     GABD_ECOLI|P25526 succinate-semialdehyde dehydrogenase
                     from Escherichia coli (482 aa); etc. Note that similar to
                     other cytosolic aldehyde dehydrogenases with EC number:
                     1.2.1.3. Also similar to Rv0768|aldA semialdehyde
                     dehydrogenase from Mycobacterium tuberculosis (489 aa);
                     and gabD2|Rv1731|MTCY04C12.16 possible
                     succinate-semialdehyde dehydrogenase [NADP+] dependent
                     from Mycobacterium tuberculosis (518 aa). Contains PS00070
                     aldehyde dehydrogenases cysteine active site. Belongs to
                     the aldehyde dehydrogenases family. Could start at
                     different site by homology. Note that previously known as
                     gabD2."
                     /transl_table=11
                     /db_xref="GOA:P71989"
                     /db_xref="InterPro:IPR015590"
                     /db_xref="InterPro:IPR016160"
                     /db_xref="InterPro:IPR016161"
                     /db_xref="InterPro:IPR016162"
                     /db_xref="InterPro:IPR016163"
                     /db_xref="UniProtKB/Swiss-Prot:P71989"
BEGIN
        1 MRSVTCSATL VLPVIEPTPA DRRPRHLLLG SAGHVSGRLD TGRFVQTHPA KDVSVPIATI
       61 NPATGETVKT FTAATDDEVD AAIARAHRRF ADYRQTSFAQ RARWANATAD LLEAEADQAA
      121 AMMTLEMGKT LAAAKAEALK CAKGFRYYAE NAEALLADEP ADAAKVGASA AYGRYQPLGV
      181 ILAVMPWNFP LWQAVRFAAP ALMAGNVGLL KHASNVPQCA LYLADVIARG GFPDGCFQTL
      241 LVSSGAVEAI LRDPRVAAAT LTGSEPAGQS VGAIAGNEIK PTVLELGGSD PFIVMPSADL
      301 DAAVSTAVTG RVQNNGQSCI AAKRFIVHAD IYDDFVDKFV ARMAALRVGD PTDPDTDVGP
      361 LATEQGRNEV AKQVEDAAAA GAVIRCGGKR LDRPGWFYPP TVITDISKDM ALYTEEVFGP
      421 VASVFRAANI DEAVEIANAT TFGLGSNAWT RDETEQRRFI DDIVAGQVFI NGMTVSYPEL
      481 PFGGVKRSGY GRELSAHGIR EFCNIKTVWI A
//