LOCUS       AJF01565.1               337 aa    PRT              BCT 20-JUN-2017
DEFINITION  Mycobacterium tuberculosis H37RvSiena Double hotdog hydratase
            protein.
ACCESSION   CP007027-221
PROTEIN_ID  AJF01565.1
SOURCE      Mycobacterium tuberculosis H37RvSiena
  ORGANISM  Mycobacterium tuberculosis H37RvSiena
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1  (bases 1 to 4410911)
  AUTHORS   Santoro,F., Guerrini,V., Lazzeri,E., Iannelli,F. and Pozzi,G.
  TITLE     Genomic polymorphisms in a Laboratory Isolate of Mycobacterium
            tuberculosis Reference Strain H37Rv (ATCC27294)
  JOURNAL   New Microbiol. 40 (1), 62-69 (2017)
   PUBMED   27819398
REFERENCE   2  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-DEC-2013) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
REFERENCE   3  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-FEB-2015) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
  REMARK    Protein update by submitter
COMMENT     Annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (released 2013). Information about the Pipeline can be
            found here: http://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            
            Annotation modified by submitter.
            
            ##Assembly-Data-START##
            Assembly Method       :: Ray v. 2.3.1
            Coverage              :: 300
            Sequencing Technology :: Illumina
            ##Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Provider          :: NCBI
            Annotation Date              :: 12/30/2013 09:28:23
            Annotation Pipeline          :: NCBI Prokaryotic Genome Annotation
                                            Pipeline
            Annotation Method            :: Best-placed reference protein set;
                                            GeneMarkS+
            Annotation Software revision :: 2.3 (rev. 422554)
            Features Annotated           :: Gene; CDS; rRNA; tRNA; ncRNA;
                                            repeat_region
            Genes                        :: 4,146
            CDS                          :: 4,050
            Pseudo Genes                 :: 42
            CRISPR Arrays                :: 2
            rRNAs                        :: 3 (5S, 16S, 23S)
            tRNAs                        :: 45
            ncRNA                        :: 6
            Frameshifted Genes           :: 34
            ##Genome-Annotation-Data-END##
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis H37RvSiena"
                     /mol_type="genomic DNA"
                     /strain="H37RvSiena"
                     /db_xref="taxon:1437856"
     protein         /locus_tag="Y980_0216"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /note="Rv0216, (MTCY08D5.11) Double hotdog R-specific
                     hydratase of unknown function, shows no activity for
                     crotonyl-CoA, equivalent to Z95398|MLCL622_22 from
                     Mycobacterium leprae (339 aa). Shows structural similarity
                     to six others in Mycobacterium tuberculosis (see Castell
                     et al (2005) below). A core mycobacterial gene; conserved
                     in mycobacterial strains (See Marmiesse et al., 2004)."
                     /transl_table=11
                     /db_xref="GOA:P96398"
                     /db_xref="InterPro:IPR016790"
                     /db_xref="PDB:2BI0"
                     /db_xref="UniProtKB/TrEMBL:P96398"
BEGIN
        1 MASGYGGIRV GGPYFDDLSK GQVFDWAPGV TLSLGLAAAH QSIVGNRLRL ALDSDLCAAV
       61 TGMPGPLAHP GLVCDVAIGQ STLATQRVKA NLFYRGLRFH RFPAVGDTLY TRTEVVGLRA
      121 NSPKPGRAPT GLAGLRMTTI DRTDRLVLDF YRCAMLPASP DWKPGAVPGD DLSRIGADAP
      181 APAADPTAHW DGAVFRKRVP GPHFDAGIAG AVLHSTADLV SGAPELARLT LNIAATHHDW
      241 RVSGRRLVYG GHTIGLALAQ ATRLLPNLAT VLDWESCDHT APVHEGDTLY SELHIESAQA
      301 HADGGVLGLR SLVYAVSDSA SEPDRQVLDW RFSALQF
//