LOCUS AJF01517.1 346 aa PRT BCT 20-JUN-2017 DEFINITION Mycobacterium tuberculosis H37RvSiena Mce-family protein Mce1B protein. ACCESSION CP007027-173 PROTEIN_ID AJF01517.1 SOURCE Mycobacterium tuberculosis H37RvSiena ORGANISM Mycobacterium tuberculosis H37RvSiena Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 (bases 1 to 4410911) AUTHORS Santoro,F., Guerrini,V., Lazzeri,E., Iannelli,F. and Pozzi,G. TITLE Genomic polymorphisms in a Laboratory Isolate of Mycobacterium tuberculosis Reference Strain H37Rv (ATCC27294) JOURNAL New Microbiol. 40 (1), 62-69 (2017) PUBMED 27819398 REFERENCE 2 (bases 1 to 4410911) AUTHORS Guerrini,V., Santoro,F. and Pozzi,G. TITLE Direct Submission JOURNAL Submitted (30-DEC-2013) Medical Biotechnology, University of Siena, viale Bracci, Policlinico Le Scotte, Siena 53100, Italy REFERENCE 3 (bases 1 to 4410911) AUTHORS Guerrini,V., Santoro,F. and Pozzi,G. TITLE Direct Submission JOURNAL Submitted (20-FEB-2015) Medical Biotechnology, University of Siena, viale Bracci, Policlinico Le Scotte, Siena 53100, Italy REMARK Protein update by submitter COMMENT Annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (released 2013). Information about the Pipeline can be found here: http://www.ncbi.nlm.nih.gov/genome/annotation_prok/ Annotation modified by submitter. ##Assembly-Data-START## Assembly Method :: Ray v. 2.3.1 Coverage :: 300 Sequencing Technology :: Illumina ##Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Date :: 12/30/2013 09:28:23 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline Annotation Method :: Best-placed reference protein set; GeneMarkS+ Annotation Software revision :: 2.3 (rev. 422554) Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA; repeat_region Genes :: 4,146 CDS :: 4,050 Pseudo Genes :: 42 CRISPR Arrays :: 2 rRNAs :: 3 (5S, 16S, 23S) tRNAs :: 45 ncRNA :: 6 Frameshifted Genes :: 34 ##Genome-Annotation-Data-END## FEATURES Qualifiers source /organism="Mycobacterium tuberculosis H37RvSiena" /mol_type="genomic DNA" /strain="H37RvSiena" /db_xref="taxon:1437856" protein /gene="mce1B" /locus_tag="Y980_0170" /gene_synonym="mceD" /experiment="EXISTENCE: identified in proteomics study" /note="Rv0170, (MTCI28.10) Mce1B (alternate gene name: mceD); belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below),highly similar to Mycobacterium tuberculosis proteins O07788|Rv0590|MTCY19H5.32c|mce2B (275 aa); O53968|Rv1967|MTV051.05|mce3B (342 aa); etc. Also highly similar to others e.g. NP_302657.1|NC_002677 putative secreted protein from Mycobacterium leprae (346 aa); CAC12797.1|AL445327 putative secreted protein from Streptomyces coelicolor (354 aa); etc. Contains hydrophobic region in N-terminal 30 residues. In Escherichia coli,N-terminal part is functional and directs export of a leaderless beta-lactamase into the periplasm (see Chubb et al., 1998). Predicted to be an outer membrane protein (See Song et al., 2008)." /transl_table=11 /db_xref="InterPro:IPR003399" /db_xref="InterPro:IPR005693" /db_xref="InterPro:IPR024516" /db_xref="UniProtKB/TrEMBL:L7N4C4" BEGIN 1 MKITGTVVKL GIVSVVLLFF TVMIIVIFGQ MRFDRTNGYT AEFSNVSGLR QGQFVRASGV 61 EIGKVKALHL VDGGRRVRVE FNIDRSVPLY QSTTAQIRYS DLIGNRYVEL KRGEGKGAND 121 LLPPGGLIPL SRTSPALDLD ALIGGFKPVF RALDPAKVNN IANALITVFQ GQGGTINDIL 181 DQTAQLTSQI AERDQAIGEV VKNLNIVLDT TVKHRKEFDE TVNNLENLIT GLRNHSDQLA 241 GGLAHISNGA GTVADLLAEN RTLVRKAVSY LDAIQQPVID QRVELDDLLH KTPTALTALG 301 RANGTYGDFQ NFYLCDLQIK WNGFQAGGPV RTVKLFSQPT GRCTPQ //