LOCUS       AJF01517.1               346 aa    PRT              BCT 20-JUN-2017
DEFINITION  Mycobacterium tuberculosis H37RvSiena Mce-family protein
            Mce1B protein.
ACCESSION   CP007027-173
PROTEIN_ID  AJF01517.1
SOURCE      Mycobacterium tuberculosis H37RvSiena
  ORGANISM  Mycobacterium tuberculosis H37RvSiena
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1  (bases 1 to 4410911)
  AUTHORS   Santoro,F., Guerrini,V., Lazzeri,E., Iannelli,F. and Pozzi,G.
  TITLE     Genomic polymorphisms in a Laboratory Isolate of Mycobacterium
            tuberculosis Reference Strain H37Rv (ATCC27294)
  JOURNAL   New Microbiol. 40 (1), 62-69 (2017)
   PUBMED   27819398
REFERENCE   2  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-DEC-2013) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
REFERENCE   3  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-FEB-2015) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
  REMARK    Protein update by submitter
COMMENT     Annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (released 2013). Information about the Pipeline can be
            found here: http://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            
            Annotation modified by submitter.
            
            ##Assembly-Data-START##
            Assembly Method       :: Ray v. 2.3.1
            Coverage              :: 300
            Sequencing Technology :: Illumina
            ##Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Provider          :: NCBI
            Annotation Date              :: 12/30/2013 09:28:23
            Annotation Pipeline          :: NCBI Prokaryotic Genome Annotation
                                            Pipeline
            Annotation Method            :: Best-placed reference protein set;
                                            GeneMarkS+
            Annotation Software revision :: 2.3 (rev. 422554)
            Features Annotated           :: Gene; CDS; rRNA; tRNA; ncRNA;
                                            repeat_region
            Genes                        :: 4,146
            CDS                          :: 4,050
            Pseudo Genes                 :: 42
            CRISPR Arrays                :: 2
            rRNAs                        :: 3 (5S, 16S, 23S)
            tRNAs                        :: 45
            ncRNA                        :: 6
            Frameshifted Genes           :: 34
            ##Genome-Annotation-Data-END##
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis H37RvSiena"
                     /mol_type="genomic DNA"
                     /strain="H37RvSiena"
                     /db_xref="taxon:1437856"
     protein         /gene="mce1B"
                     /locus_tag="Y980_0170"
                     /gene_synonym="mceD"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /note="Rv0170, (MTCI28.10) Mce1B (alternate gene name:
                     mceD); belongs to 24-membered Mycobacterium tuberculosis
                     Mce protein family (see citations below),highly similar to
                     Mycobacterium tuberculosis proteins
                     O07788|Rv0590|MTCY19H5.32c|mce2B (275 aa);
                     O53968|Rv1967|MTV051.05|mce3B (342 aa); etc. Also highly
                     similar to others e.g. NP_302657.1|NC_002677 putative
                     secreted protein from Mycobacterium leprae (346 aa);
                     CAC12797.1|AL445327 putative secreted protein from
                     Streptomyces coelicolor (354 aa); etc. Contains
                     hydrophobic region in N-terminal 30 residues. In
                     Escherichia coli,N-terminal part is functional and directs
                     export of a leaderless beta-lactamase into the periplasm
                     (see Chubb et al., 1998). Predicted to be an outer
                     membrane protein (See Song et al., 2008)."
                     /transl_table=11
                     /db_xref="InterPro:IPR003399"
                     /db_xref="InterPro:IPR005693"
                     /db_xref="InterPro:IPR024516"
                     /db_xref="UniProtKB/TrEMBL:L7N4C4"
BEGIN
        1 MKITGTVVKL GIVSVVLLFF TVMIIVIFGQ MRFDRTNGYT AEFSNVSGLR QGQFVRASGV
       61 EIGKVKALHL VDGGRRVRVE FNIDRSVPLY QSTTAQIRYS DLIGNRYVEL KRGEGKGAND
      121 LLPPGGLIPL SRTSPALDLD ALIGGFKPVF RALDPAKVNN IANALITVFQ GQGGTINDIL
      181 DQTAQLTSQI AERDQAIGEV VKNLNIVLDT TVKHRKEFDE TVNNLENLIT GLRNHSDQLA
      241 GGLAHISNGA GTVADLLAEN RTLVRKAVSY LDAIQQPVID QRVELDDLLH KTPTALTALG
      301 RANGTYGDFQ NFYLCDLQIK WNGFQAGGPV RTVKLFSQPT GRCTPQ
//