LOCUS       AJF01499.1               276 aa    PRT              BCT 20-JUN-2017
DEFINITION  Mycobacterium tuberculosis H37RvSiena Phosphotyrosine
            protein phosphatase PTPB (protein-tyrosine-phosphatase)
            (PTPase) protein.
ACCESSION   CP007027-155
PROTEIN_ID  AJF01499.1
SOURCE      Mycobacterium tuberculosis H37RvSiena
  ORGANISM  Mycobacterium tuberculosis H37RvSiena
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1  (bases 1 to 4410911)
  AUTHORS   Santoro,F., Guerrini,V., Lazzeri,E., Iannelli,F. and Pozzi,G.
  TITLE     Genomic polymorphisms in a Laboratory Isolate of Mycobacterium
            tuberculosis Reference Strain H37Rv (ATCC27294)
  JOURNAL   New Microbiol. 40 (1), 62-69 (2017)
   PUBMED   27819398
REFERENCE   2  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-DEC-2013) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
REFERENCE   3  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-FEB-2015) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
  REMARK    Protein update by submitter
COMMENT     Annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (released 2013). Information about the Pipeline can be
            found here: http://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            
            Annotation modified by submitter.
            
            ##Assembly-Data-START##
            Assembly Method       :: Ray v. 2.3.1
            Coverage              :: 300
            Sequencing Technology :: Illumina
            ##Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Provider          :: NCBI
            Annotation Date              :: 12/30/2013 09:28:23
            Annotation Pipeline          :: NCBI Prokaryotic Genome Annotation
                                            Pipeline
            Annotation Method            :: Best-placed reference protein set;
                                            GeneMarkS+
            Annotation Software revision :: 2.3 (rev. 422554)
            Features Annotated           :: Gene; CDS; rRNA; tRNA; ncRNA;
                                            repeat_region
            Genes                        :: 4,146
            CDS                          :: 4,050
            Pseudo Genes                 :: 42
            CRISPR Arrays                :: 2
            rRNAs                        :: 3 (5S, 16S, 23S)
            tRNAs                        :: 45
            ncRNA                        :: 6
            Frameshifted Genes           :: 34
            ##Genome-Annotation-Data-END##
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis H37RvSiena"
                     /mol_type="genomic DNA"
                     /strain="H37RvSiena"
                     /db_xref="taxon:1437856"
     protein         /gene="ptbB"
                     /locus_tag="Y980_0153c"
                     /gene_synonym="MPtpB"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /note="Rv0153c, (MTCI5.27c) PtbB (alternate gene name:
                     MPtpB), protein-tyrosine-phosphatase (see citation below),
                     showing some similarity to several protein-tyrosine
                     phosphatases, polyketide synthase and aminotransferase
                     e.g. Q05918|IPHP_NOSCO|IPH protein-tyrosine-phosphatase
                     precursor from Nostoc commune (294 aa); etc. Supposedly a
                     secreted protein. Potent and selective inhibitor is an
                     isoxazole compound (See Seollner et al., 2007)."
                     /transl_table=11
                     /db_xref="GOA:P96830"
                     /db_xref="InterPro:IPR000387"
                     /db_xref="InterPro:IPR025163"
                     /db_xref="InterPro:IPR026893"
                     /db_xref="PDB:1YWF"
                     /db_xref="PDB:2OZ5"
                     /db_xref="UniProtKB/TrEMBL:P96830"
BEGIN
        1 MAVRELPGAW NFRDVADTAT ALRPGRLFRS SELSRLDDAG RATLRRLGIT DVADLRSSRE
       61 VARRGPGRVP DGIDVHLLPF PDLADDDADD SAPHETAFKR LLTNDGSNGE SGESSQSIND
      121 AATRYMTDEY RQFPTRNGAQ RALHRVVTLL AAGRPVLTHC FAGKDRTGFV VALVLEAVGL
      181 DRDVIVADYL RSNDSVPQLR ARISEMIQQR FDTELAPEVV TFTKARLSDG VLGVRAEYLA
      241 AARQTIDETY GSLGGYLRDA GISQATVNRM RGVLLG
//