LOCUS       AJF01471.1               355 aa    PRT              BCT 20-JUN-2017
DEFINITION  Mycobacterium tuberculosis H37RvSiena putative serine
            protease PepA (serine proteinase) (MTB32A) protein.
ACCESSION   CP007027-127
PROTEIN_ID  AJF01471.1
SOURCE      Mycobacterium tuberculosis H37RvSiena
  ORGANISM  Mycobacterium tuberculosis H37RvSiena
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1  (bases 1 to 4410911)
  AUTHORS   Santoro,F., Guerrini,V., Lazzeri,E., Iannelli,F. and Pozzi,G.
  TITLE     Genomic polymorphisms in a Laboratory Isolate of Mycobacterium
            tuberculosis Reference Strain H37Rv (ATCC27294)
  JOURNAL   New Microbiol. 40 (1), 62-69 (2017)
   PUBMED   27819398
REFERENCE   2  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-DEC-2013) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
REFERENCE   3  (bases 1 to 4410911)
  AUTHORS   Guerrini,V., Santoro,F. and Pozzi,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-FEB-2015) Medical Biotechnology, University of Siena,
            viale Bracci, Policlinico Le Scotte, Siena 53100, Italy
  REMARK    Protein update by submitter
COMMENT     Annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (released 2013). Information about the Pipeline can be
            found here: http://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            
            Annotation modified by submitter.
            
            ##Assembly-Data-START##
            Assembly Method       :: Ray v. 2.3.1
            Coverage              :: 300
            Sequencing Technology :: Illumina
            ##Assembly-Data-END##
            
            ##Genome-Annotation-Data-START##
            Annotation Provider          :: NCBI
            Annotation Date              :: 12/30/2013 09:28:23
            Annotation Pipeline          :: NCBI Prokaryotic Genome Annotation
                                            Pipeline
            Annotation Method            :: Best-placed reference protein set;
                                            GeneMarkS+
            Annotation Software revision :: 2.3 (rev. 422554)
            Features Annotated           :: Gene; CDS; rRNA; tRNA; ncRNA;
                                            repeat_region
            Genes                        :: 4,146
            CDS                          :: 4,050
            Pseudo Genes                 :: 42
            CRISPR Arrays                :: 2
            rRNAs                        :: 3 (5S, 16S, 23S)
            tRNAs                        :: 45
            ncRNA                        :: 6
            Frameshifted Genes           :: 34
            ##Genome-Annotation-Data-END##
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis H37RvSiena"
                     /mol_type="genomic DNA"
                     /strain="H37RvSiena"
                     /db_xref="taxon:1437856"
     protein         /gene="pepA"
                     /locus_tag="Y980_0125"
                     /gene_synonym="mtb32a"
                     /experiment="EXISTENCE: identified in proteomics study"
                     /inference="protein motif:PROSITE:PS00135"
                     /note="Rv0125, (MTCI418B.07, MTB32A) Probable pepA
                     (alternate gene name: mtb32a), serine protease (see Skeiky
                     et al., 1999), highly similar to other proteases e.g.
                     HHOB_ECOLI|P31137 protease hhob precursor (355 aa). Also
                     similar to Q50320 34 kDa protein precursor from
                     Mycobacterium tuberculosis (361 aa). Contains PS00135
                     Serine proteases, trypsin family, serine active site. Has
                     a putative signal sequence at the N-terminus. Belongs to
                     the serine protease family. Conserved in M. tuberculosis,
                     M. leprae, M. bovis and M. avium paratuberculosis;
                     predicted to be essential for in vivo survival and
                     pathogenicity (See Ribeiro-Guimaraes and Pessolani,
                     2007)."
                     /transl_table=11
                     /db_xref="GOA:L7N4F0"
                     /db_xref="InterPro:IPR001478"
                     /db_xref="InterPro:IPR001940"
                     /db_xref="InterPro:IPR006311"
                     /db_xref="InterPro:IPR009003"
                     /db_xref="UniProtKB/TrEMBL:L7N4F0"
BEGIN
        1 MSNSRRRSLR WSWLLSVLAA VGLGLATAPA QAAPPALSQD RFADFPALPL DPSAMVAQVG
       61 PQVVNINTKL GYNNAVGAGT GIVIDPNGVV LTNNHVIAGA TDINAFSVGS GQTYGVDVVG
      121 YDRTQDVAVL QLRGAGGLPS AAIGGGVAVG EPVVAMGNSG GQGGTPRAVP GRVVALGQTV
      181 QASDSLTGAE ETLNGLIQFD AAIQPGDSGG PVVNGLGQVV GMNTAASDNF QLSQGGQGFA
      241 IPIGQAMAIA GQIRSGGGSP TVHIGPTAFL GLGVVDNNGN GARVQRVVGS APAASLGIST
      301 GDVITAVDGA PINSATAMAD ALNGHHPGDV ISVTWQTKSG GTRTGNVTLA EGPPA
//